Prognostic importance of tissue Doppler imaging of systolic and diastolic functions in dogs with severe sepsis and septic shock

Ince, Mehmet Ege; Turgut, K.; Akar, Aybars; Naseri, Amir; Şen, İsmai̇l; Süleymanoğlu, Havva; Ertan, Merve; Sağmanligil, Vedat

doi:10.1556/004.2019.051

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…In sepsis or SIRS, the release of inflammatory mediators causes distributed shock. Septic shock is a type of shock that is classified as a subtype of distributive shock (22). Different processes, including as hypovolemia, vasoplegia, and septic cardiomyopathy, are frequently found simultaneously or separately in this complex process.…”

Section: Discussionmentioning

confidence: 99%

“…Vasoactive therapy: Despite receiving a single bolus of fluid treatment, hypotensive dogs were given vasopressor therapy by delivering NE (1.5 µg/kg/min in 0.9 percent NaCl solution) without a loading dose. If an acceptable clinical reply was not obtained after 2 hours, the dosage of NE administration in 0.9 percent NaCl solution was increased to 3.0 µg/kg/min (22,41). DT was administered to dogs with LVS'<7.5…”

Section: Treatment Protocolmentioning

confidence: 99%

“…When the immune system overreacts to an infection, organ failure results. In dogs, sepsis-induced myocardial dysfunction (SiMD) is caused by canine parvovirus infection (CPVI) (22).…”

Section: Introductionmentioning

confidence: 99%

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Vasoactive use in early goal-directed therapy in dogs with severe sepsis and septic shock

Süleymanoğlu

Turgut

Ertan

et al. 2023

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The purpose of the present study was to evaluate the changes in macrovascular and microvascular parameters in survivors (Sv) and non-survivors (non-Sv) dogs with severe sepsis and septic shock (SS&SS) in response to goal-directed hemodynamic optimization at the intensive care unit (ICU), and to evaluate norepinephrine (NE) and dobutamine (DT) ICU applications, and their effectiveness for predicting death. Thirty-five dogs with SS&SS were used. NE was given to 10 hypotensive dogs, despite one bolus of fluid therapy, at a constant infusion rate of 1.5 µg/kg/min for 2 h. If the clinical response was inadequate after 2 h, the rate of NE infusion was doubled (3.0 µg/kg/min). DT was administered to 5 dogs with left ventricular systolic dysfunction (LVSD) (LVS’

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Section: Discussionmentioning

confidence: 99%

Section: Treatment Protocolmentioning

confidence: 99%

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Vasoactive use in early goal-directed therapy in dogs with severe sepsis and septic shock

Süleymanoğlu

Turgut

Ertan

et al. 2023

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…It can be used to objectively and quantitatively evaluate cardiac function and coordination, and has become the gold standard for evaluating septic cardiomyopathy. 4 …”

Section: Introductionmentioning

confidence: 99%

“…It can be used to objectively and quantitatively evaluate cardiac function and coordination, and has become the gold standard for evaluating septic cardiomyopathy. 4 In clinic, the forward flow spectrum of mitral valve during diastolic period obtained by pulsed Doppler ultrasound is the most commonly used method to judge left ventricular diastolic function. However, the spectrum of mitral valve flow is often affected by many factors, such as age, mitral valve pressure gradient, left atrial size, anteroposterior cardiac load and left ventricular systolic function.…”

Section: Introductionmentioning

confidence: 99%

Early Diastolic Peak Velocity of Mitral Valve Annulus and Right Ventricular Systolic Tricuspid Annular Velocity as Predictors in Assessing Prognosis of Patients with Sepsis

Lu¹,

Shao²,

Niu³

et al. 2023

RMHP

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Objective To analyze the epidemiological data of patients with septic cardiomyopathy and investigate the relationship between ultrasonic parameters and prognosis of patients with sepsis. Methods In this study, we enrolled patients with sepsis who were treated at the Department of Critical Care Medicine in the Beijing Electric Power Hospital (No.1 Taipingqiao Xili, Fengtai District, Beijing) from January 2020 to June 2022. All patients received standardized treatment. Their general medical status and 28-day prognosis were recorded. Transthoracic echocardiography was performed within 24 hours after admission. We compared the ultrasound indexes between the mortality group and the survival group at the end of 28 days. We included parameters with significant difference in the logistic regression model to identify the independent risk factors for prognosis and evaluated their predictive value using receiver operating characteristic (ROC) curve. Results We included 100 patients with sepsis in this study; the mortality rate was 33% and the prevalence rate of septic cardiomyopathy was 49%. The peak e’ velocity and right ventricular systolic tricuspid annulus velocity (RV-Sm) of the survival group were significantly higher than those of the mortality group ( P < 0.05). Results of logistic regression analysis showed that the peak e’ velocity and RV-Sm were independent risk factors for prognosis. The area under curve of the peak e’ velocity and the RV-Sm was 0.657 and 0.668, respectively ( P < 0.05). Conclusion The prevalence rate of septic cardiomyopathy in septic patients is high. In this study, we found that the peak e’ velocity and right ventricular systolic tricuspid annulus velocity were important predictors of short-term prognosis.

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Echocardiographic Assessment of Left Ventricular Systolic and Diastolic Functions in Dogs with Severe Sepsis and Septic Shock; Longitudinal Study

Ince

Turgut

Naseri

2021

Animals

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The purpose of this study was to monitor left ventricular systolic dysfunction (LVSD) and diastolic dysfunction (LVDD) using transthoracic echocardiography (TTE) in dogs with severe sepsis and septic shock (SS/SS). A prospective longitudinal study using 23 dogs with SS/SS (experimental group) and 20 healthy dogs (control group) were carried out. All the clinical, laboratory and cardiologic examinations for the experimental dogs were performed at admission, 6 and 24 h after the start of treatment and on the day of discharge. LVSD was described as LV ejection fraction (LVEF) < 50%. LVDD was determined when the septal mitral annulus early diastolic velocity (LVEm) was <8 cm/s. LVSD and LVDD were present in 3 and 16 dogs with SS/SS, respectively, with both types of dysfunction present in 2 of the dogs. Although all the dogs with LVSD survived, 8 dogs with LVDD did not. The survival period was significantly shorter in dogs with an LVEm < 8 cm/s (1.3 ± 1.4 days). In conclusion, LVDD, rather than LVSD, was a common cardiovascular abnormality in the septic dogs, and this may be a negative prognostic factor. TTE is a useful tool for the identifying and monitoring of myocardial dysfunction in the dogs with SS/SS.

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Prognostic importance of tissue Doppler imaging of systolic and diastolic functions in dogs with severe sepsis and septic shock

Cited by 4 publications

References 35 publications

Vasoactive use in early goal-directed therapy in dogs with severe sepsis and septic shock

Vasoactive use in early goal-directed therapy in dogs with severe sepsis and septic shock

Early Diastolic Peak Velocity of Mitral Valve Annulus and Right Ventricular Systolic Tricuspid Annular Velocity as Predictors in Assessing Prognosis of Patients with Sepsis

Echocardiographic Assessment of Left Ventricular Systolic and Diastolic Functions in Dogs with Severe Sepsis and Septic Shock; Longitudinal Study

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