Prognostic Importance of Scintigraphic Left Ventricular Cavity Dilation During Intravenous Dipyridamole Technetium-99m Sestamibi Myocardial Tomographic Imaging in Predicting Coronary Events

McClellan, Joseph R.; Travin, Mark I.; Herman, Steven D.; Baron, John I.; Golub, R.; Gallagher, James J.; Waters, David D.; Heller, Gary V.

doi:10.1016/s0002-9149(96)00823-5

Cited by 80 publications

(46 citation statements)

References 24 publications

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“…8, 27 With visual analysis of the LV cavity size in 512 patients during dipyridamole sestamibi SPECT, McClellan et al reported that transient LV dilation was associated with nonfatal MI, and fixed dilation was predictive of cardiac death and hospitalization for heart failure. 28 In contrast to transient ischemic dilation, fixed LV dilation is usually associated with reduced LVEF at rest. 29 Thus, results of McClellan et al are consistent with ours because the LVEF at rest was the best single predictor for cardiac events when severe heart failure was included in the events ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Post-Ischemic Stunning as Assessed by Gated Myocardial Perfusion Single-Photon Emission Computed Tomography - A Subanalysis of the J-ACCESS Study -

Usui

Chikamori

Nakajima

et al. 2010

Circ J

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Post-Ischemic Stunning as Assessed by Gated Myocardial Perfusion Single-Photon Emission Computed Tomography - A Subanalysis of the J-ACCESS Study -

Usui

Chikamori

Nakajima

et al. 2010

Circ J

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“…15- 18 The most widely accepted method at present is the computer-derived automated calculation of LV volume at stress and rest using a standard software package. 7 However, the results reported in several important studies on the diagnostic and prognostic values of the TID ratio were predominantly derived from the separate-acquisition dual isotope, at rest, thallium-201/stress 99 m Tc sestamibi SPECT protocol.…”

Section: Discussionmentioning

confidence: 99%

Postischemic Myocardial Stunning Is Superior to Transient Ischemic Dilation for Detecting Multivessel Coronary Artery Disease

Hida

Chikamori

Tanaka

et al. 2012

Circ J

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“…In particular, McClellan et al 22 reported on 512 consecutive patients (25% with diabetes mellitus) who underwent dipyridamole stress MPS. During a follow-up period of 13±7 months, cardiac event rates, including cardiac death and nonfatal MI, were significantly higher in patients with TID (11%) and in those with fixed dilation (14%) than in those with normal LV size (2%).…”

Section: Prognostic Value Of Tidmentioning

confidence: 99%

Transient Ischemic Dilation in Patients With Diabetes Mellitus

Petretta

Acampa

Daniele

et al. 2013

Circ: Cardiovascular Imaging

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Background-We prospectively evaluated the incremental prognostic value of transient ischemic dilation (TID) in patients with type 2 diabetes mellitus during long-term follow-up and estimated cardiac death and nonfatal myocardial infarction (MI) using traditional approaches of prognostication to more recent methods. Methods and Results-A total of 672 consecutive diabetic patients with available rest and stress gated myocardial perfusion single-photon emission computed tomographic data were enrolled. Stepwise Cox regression analysis was used to estimate cardiac death or nonfatal MI. Risk reclassification was calculated, and an exploratory analysis was performed to evaluate the effect of coronary revascularization on event-free survival. Adding TID to a multivariable model, including age, history of MI, stress type, poststress left ventricular ejection fraction, and stress-induced myocardial ischemia, improved discrimination of cardiac death or nonfatal MI (C statistic, 0.74-0.82; P=0.01; adjusted hazard ratio, 3.6; P<0.0001) and led to a net reclassification improvement of 0.39 (95% confidence interval, 0.14-0.64). Revascularization had a significant effect on event-free survival (adjusted hazard ratio, 0.25; P<0.001), with significant interactions between revascularization and poststress left ventricular ejection fraction, revascularization and stress-induced myocardial ischemia, and revascularization and TID (all P<0.01) Conclusions-TID provides independent and incremental prognostic information for the prediction of cardiac death or nonfatal MI in patients with diabetes mellitus. The addition of TID to a prediction model based on cardiovascular risk factors, left ventricular ejection fraction, and ischemia significantly improves risk discrimination and reclassification for incident cardiac events. The effect of revascularization seems to be influenced by left ventricular systolic function, stressinduced myocardial ischemia, and TID. (Circ Cardiovasc Imaging. 2013;6:908-915.)

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Prognostic Importance of Scintigraphic Left Ventricular Cavity Dilation During Intravenous Dipyridamole Technetium-99m Sestamibi Myocardial Tomographic Imaging in Predicting Coronary Events

Cited by 80 publications

References 24 publications

Prognostic Value of Post-Ischemic Stunning as Assessed by Gated Myocardial Perfusion Single-Photon Emission Computed Tomography - A Subanalysis of the J-ACCESS Study -

Prognostic Value of Post-Ischemic Stunning as Assessed by Gated Myocardial Perfusion Single-Photon Emission Computed Tomography - A Subanalysis of the J-ACCESS Study -

Postischemic Myocardial Stunning Is Superior to Transient Ischemic Dilation for Detecting Multivessel Coronary Artery Disease

Transient Ischemic Dilation in Patients With Diabetes Mellitus

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