Prognostic importance of neutrophil-lymphocyte ratio in critically ill patients: short- and long-term outcomes

Akıllı, Nazire Belgin; Yortanlı, Mehmet; Mutlu, Haşim; Günaydın, Yahya Kemal; Köylü, Ramazan; Akça, Hatice Şeyma; Akıncı, Emine; Dündar, Zerrin Defne; Cander, Başar

doi:10.1016/j.ajem.2014.09.001

Cited by 81 publications

(79 citation statements)

References 18 publications

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“…The association between increased F I G U R E 2 Levels of neutrophil-to-lymphocyte ratio (NLR), plasma lactate, procalcitonin (PCT), and C-reactive protein (CRP) mortality and raised NLR was also consistent with that in prior studies; Shahidi reported that the NLR was a simple, cheap, rapidly accessible, and independent indicator of short-and long-term mortalities in critically ill patients. 18 WBCs, in particular neutrophils and lymphocytes, are known to play an important role in the inflammatory processes of chronic diseases, such as atherosclerosis. 19,20 NLR also had proven useful for predicting intensive care suitability and mortality in patients with community-acquired pneumonia.…”

Section: Correlation With Conventional Inflammationrelated Biomarkersmentioning

confidence: 99%

Neutrophil‐lymphocyte ratio and plasma lactate predict 28‐day mortality in patients with sepsis

Liu

Zheng

Zhang³

et al. 2019

Clinical Laboratory Analysis

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ObjectiveThe predictive potential of the neutrophil‐to‐lymphocyte ratio (NLR) and plasma lactate was investigated in regard to the prognosis of patients with sepsis.MethodsSixty‐three nonsurgical and nontrauma adult patients with sepsis admitted to the intensive care unit (ICU) from September 2016 to October 2018 were consecutively included in the study. In addition, healthy subjects were assigned to a control group. Neutrophil and lymphocyte counts were evaluated via a complete blood count. Plasma lactate, procalcitonin (PCT), and C‐reactive protein (CRP) levels were measured. The main outcome was 28‐day mortality.ResultsNeutrophil‐to‐lymphocyte ratio and plasma lactate levels of the patients were significantly higher than those of control subjects: 19.44 (14.3‐34.53) vs 14.09 (8.17‐28.99), P = 0.049; and 3.7 (3‐6.6) vs 2.72 (2.13‐4.3) ng/mL, P = 0.008, respectively. There were no statistical differences in the concentrations of PCT and CRP between nonsurvivors and survivors: 6.1 (3.43‐33.59) vs 9.43 (4.24‐37.68) ng/mL, P = 0.44; and 108 (77.8‐153) vs 114.5 (71.43‐162) ng/mL, P = 0.672, respectively. With an optimal cutoff of 14.08, the sensitivity and specificity of NLR for prediction of 28‐day mortality were 78.3% and 50%, respectively. And the sensitivity and specificity of plasma lactate level to predict 28‐day mortality, at an optimal cutoff value of 2.99 mmol/L, were 82.6% and 55%, respectively.ConclusionsNeutrophil‐to‐lymphocyte ratio and plasma lactate were associated with poor outcomes in patients with sepsis and predicted mortality.

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Section: Correlation With Conventional Inflammationrelated Biomarkersmentioning

confidence: 99%

Neutrophil‐lymphocyte ratio and plasma lactate predict 28‐day mortality in patients with sepsis

Liu

Zheng

Zhang³

et al. 2019

Clinical Laboratory Analysis

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“…Akıllı ve ark. [17] bir acil serviste 373 hastayı içeren bir prospektif çalışmada, yüksek NLO düzeyleri hastanede ve 6 aylık mortalitede yüksek riske atfedilmiştir. NLO artışı hakkında her ne kadar mortaliteyi arttırdığına dâhil çalışmalar olsa da, bazı çelişkili çalışmalarda olduğundan daha fazla ve randomize kontrollü prospektif çalışmalar ile desteklenmesi doğru olacaktır.…”

Section: Discussionunclassified

The relation of hemogram parameters with mortality in intensive care patients.

Şenyurt¹,

Kaygusuz²,

Avcı³

et al. 2018

GKDA Derg

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“…In the study performed by Salciccioli et al [3], a correlation was found between NLR and 1-year mortality in the critically ill patients followed up in the ICU, but a separate classification for sepsis patients was performed only for 28-day mortality. Although NLR, hospital mortality, and 6-month mortality were defined to be an independent factor in the study performed by Akilli et al [21]. a separate subgroup analysis was not performed for patients with sepsis, who comprised 9.4% of the cases in this study.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Association Between the Neutrophil to Lymphocyte Ratio and Mortality in the Patients Followed up with the Diagnosis of Sepsis

Korkmaz¹

2017

Ann Clin Anal Med

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NLR quartillere ayrıldığında NLR quartilleri arttıkça YBÜ'sinde mortalite oranı artmakla birlikte quartiller arasında mortalite yönünden anlamlı bir fark saptanmamıştır (tüm p>0.05). Hastalar 6 ay sonu mortalite yönünden değer-lendirildiğinde NLR ile arasında anlamlı bir ilişki saptanmadı (p>0.05). Tartışma: Çalışmamızda sepsis hastalarında NLR ile YBÜ'sindeki mortalite oranı ve uzun dönem mortalite oranı arasında anlamlı bir ilişki bulunmamıştır. Anahtar KelimelerNötrofil Lenfosit Oranı; Sepsis; Mortalite AbstractAim: Neutrophil-to-lymphocyte ratio (NLR) is an easily measurable biomarker from complete blood count. NLR has been investigated previously as a potential predictor of survival rates in various types of cancers. However, there is a limited number of studies performed regarding the usefulness of NLR for predicting mortality in patients with sepsis. Our aim in this study was to evaluate the association between NLR and mortality of the patients with sepsis in an intensive care unit (ICU). Material and Method: We retrospectively assessed the patients who were followed up with the diagnosis of sepsis in the internal medicine ICU of our hospital between September 1, 2014and December 31, 2015. Demographic, clinical, and laboratory data were obtained from the patients' medical records. Results: A total of 104 patients were included in the study. ICU mortality was 57.7% in patients with sepsis.When survivors and non-survivors in theICU were assessed regarding neutrophil counts, lymphocyte counts, and NLR, no statistically significant difference was determined (p>0.05). While the mortality rate in ICU increased with increasing quartile of NLR, no significant difference was determined in ICU mortality (all p>0.05). Also there was no relationship between NLR and hospital mortality and 6-months mortality in patients with sepsis (p>0.05).Discussion: No significant correlation was found between NLR and mortality rate in the ICU and long-term mortality in patients with sepsis.

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Prognostic importance of neutrophil-lymphocyte ratio in critically ill patients: short- and long-term outcomes

Cited by 81 publications

References 18 publications

Neutrophil‐lymphocyte ratio and plasma lactate predict 28‐day mortality in patients with sepsis

Neutrophil‐lymphocyte ratio and plasma lactate predict 28‐day mortality in patients with sepsis

The relation of hemogram parameters with mortality in intensive care patients.

Evaluation of the Association Between the Neutrophil to Lymphocyte Ratio and Mortality in the Patients Followed up with the Diagnosis of Sepsis

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