Prognostic importance of insulin-mediated glucose uptake in aged patients with congestive heart failure secondary to mitral and/or aortic valve disease

Paolisso, Giuseppe; Tagliamonte, Maria; Rizzo, Maria Rosaria; Gambardella, A.; Gualdiero, Pasquale; Lama, Diana; Varricchio, G.; Gentile, Salvatore; Varricchio, M

doi:10.1016/s0002-9149(99)00097-1

Cited by 72 publications

(58 citation statements)

References 24 publications

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“…This suggests that blood flow remains an important determinant of the regional MGU, independent of the global levels of myocardial insulin resistance. Previous evidence demonstrated that the prognostic impact of insulin resistance in HF patients is independent of values of LV ejection fraction [9]. Our results confirm this epidemiological finding and provide possible mechanistic explanations.…”

Section: Discussionsupporting

confidence: 90%

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Similar patterns of myocardial metabolism and perfusion in patients with type 2 diabetes and heart disease of ischaemic and non-ischaemic origin

et al. 2012

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Section: Discussionsupporting

confidence: 90%

“…Insulin resistance is highly prevalent in the non-ischaemic HF population [6]. It predates HF development [7], predicts the response to antiadrenergic therapy [8] and independently defines a worse prognosis [9].…”

Section: Introductionmentioning

confidence: 99%

Similar patterns of myocardial metabolism and perfusion in patients with type 2 diabetes and heart disease of ischaemic and non-ischaemic origin

et al. 2012

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“…Although heart muscle is not a major site of glucose disposal, recent clinical studies have revealed that reduced insulin sensitivity is a risk factor for mortality in individuals with coronary heart failure (Swan et al, 1997;Doehner et al, 2005). In addition, it has been shown that measurements of insulinstimulated glucose disposal are prognostic markers of coronary heart failure (Paolisso et al, 1999;Doehner et al, 2005). Heart muscle glucose transport shares many similarities to that occurring in skeletal muscle and is known to be associated with the translocation of the GLUT4 glucose transporter isoform from intracellular reservoir compartments to the limiting membranes of the sarcolemma and the transverse-tubule system of the cardiomyocytes (Fischer et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

Fazakerley

Lawrence

Lizunov

et al. 2009

Journal of Cell Science

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A new mouse model has been developed to study the localisation and trafficking of the glucose transporter GLUT4 in muscle. The mouse line has specific expression of a GFP and HA-epitope-tagged version of GLUT4 under the control of a muscle-specific promoter. The exofacial HA-tag has enabled fluorescent labelling of only the GLUT4 exposed at the external surface. A distinction between sarcolemma labelling and transverse-tubule labelling has also been possible because the former compartment is much more accessible to intact anti-HA antibody. By contrast, the Fab fragment of the anti-HA antibody could readily detect GLUT4 at the surface of both the sarcolemma and transverse tubules. Here, we have used this mouse model to examine the route taken by cardiomyocyte GLUT4 as it moves to the limiting external membrane surface of sarcolemma and transverse-tubules in response to insulin, contraction or activators of energy-status signalling, including hypoxia. HA-GLUT4-GFP is largely excluded from the sarcolemma and transverse-tubule membrane of cardiomyocytes under basal conditions, but is similarly trafficked to these membrane surfaces after stimulation with insulin, contraction or hypoxia. Internalisation of sarcolemma GLUT4 has been investigated by pulse-labelling surface GLUT4 with intact anti-HA antibody. At early stages of internalisation, HA-tagged GLUT4 colocalises with clathrin at puncta at the sarcolemma, indicating that in cells returning to a basal state, GLUT4 is removed from external membranes by a clathrin-mediated route. We also observed colocalisation of GLUT4 with clathrin under basal conditions. At later stages of internalisation and at steady state, anti-HA antibody labeled-GLUT4 originating from the sarcolemma was predominantly detected in a peri-nuclear compartment, indistinguishable among the specific initial stimuli. These results taken together imply a common pathway for internalisation of GLUT4, independent of the initial stimulus.

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“…In spite of this, the epidemiological data on heart failure are relatively scarce. Previous studies demonstrate an association between insulin resistance and heart failure (53,74) and an impaired insulin-mediated glucose uptake has been shown to be a prognostic factor in heart failure patients (56). Preliminary results from h l o v and co-workers (84) indicate that factors related to insulin resistance (10,49,52,79), such as an increased heart rate, increased serum concentrations of proinsulin, a high proportion of dihomogammalinolenic acid in serum cholesterol esters and hypophosphataemia are predictors of left ventricular systolic dysfunction in elderly males after 20 years follow-up, independently of myocardial infarction, hypertension, diabetes and the use of cardiovascular medication.…”

Section: Proinsulin In Relation To Development Of Type 2 Diabetes Andmentioning

confidence: 99%

Epidemiological and Clinical Studies on Insulin Resistance and Diabetes

Lithell¹,

Sundström²,

Ärnlöv³

et al. 2000

Upsala Journal of Medical Sciences

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In Uppsala, extensive epidemiological and clinical studies on insulin resistance and diabetes have been ongoing for the past 30 years. A prospective cohort study of men born 1920-24, living in Uppsala County, was initiated during 1969-74 (the Uppsala Longitudinal Study of Adult Men, ULSAM). Risk factors for cardiovascular disease were examined in 2,322 men, and re-examinations have been performed every 10 years. At the first follow-up, when the men were 60 years old, insulin resistance was found to be a risk factor for development of hypertension and diabetes. In addition, treatment with antihypertensive medication was an independent risk factor for development of diabetes. These findings resulted in a series of clinical studies on metabolic effects of antihypertensive agents. At the second follow-up, when the men were 70 years old, the development of hypertension and diabetes was once again in focus, but at this time, cross-sectional and prospective studies of other cardiovascular determinants, such as circadian blood pressure pattern, left ventricular geometry and function, muscle morphology, ion status, fibrinolysis and cognitive function, were also performed. The cohort has furthermore been linked to the Swedish census and hospital discharge and cause of death registries, it has been used for studies on relationships between birth weight and cardiovascular disease, and genetic analyses have been performed, taking advantage of the long observation time obtained in this cohort. The cohort is currently being re-examined for the third time, and will hopefully continue to provide valuable information on the epidemiology of diabetes and cardiovascular disease in the future.

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Prognostic importance of insulin-mediated glucose uptake in aged patients with congestive heart failure secondary to mitral and/or aortic valve disease

Cited by 72 publications

References 24 publications

Similar patterns of myocardial metabolism and perfusion in patients with type 2 diabetes and heart disease of ischaemic and non-ischaemic origin

Similar patterns of myocardial metabolism and perfusion in patients with type 2 diabetes and heart disease of ischaemic and non-ischaemic origin

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

Epidemiological and Clinical Studies on Insulin Resistance and Diabetes

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