Prognostic importance of Claudin-1 and Claudin-4 expression in colon carcinomas

Ersöz, Şafak; Munğan, Sevdegül; Çobanoğlu, Ümi̇t; Turgutalp, Havvanur; Özoran, Yavuz

doi:10.1016/j.prp.2011.01.011

Cited by 33 publications

(30 citation statements)

References 22 publications

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“…Survival analysis showed a trend toward a better prognosis among patients with overexpression of claudin-7 in tumor tissues [39]. These data suggest that the overexpression of claudins in certain tumors are useful in diagnostics [29,36,40,41,44], and may even serve as future therapeutic targets [23,45].…”

Section: Introductionmentioning

confidence: 95%

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Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

Erdélyi-Belle

Török

Apáti

et al. 2015

Pathol. Oncol. Res.

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Section: Introductionmentioning

confidence: 95%

“…In contrast to hepatocellular carcinoma (HCC) [7,39], overexpression of claudin-4 has been observed in cholangiocarcinoma [29], in colon cancer [40], in pancreatic ductal carcinoma [41] and in several other malignancies [37,42,43]. Claudin-7 is a prognostic factor for HCC [30].…”

Section: Introductionmentioning

confidence: 99%

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

Erdélyi-Belle

Török

Apáti

et al. 2015

Pathol. Oncol. Res.

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“…The complexity of CLDN1 was proposed because its dual role as a tumor suppressor and promoter, as well as a positive and negative prognostic factor in different cancers, including breast (10,11), gastric (12), ovarian (13), lung (14) and colon (15)(16)(17). Decreased expression of CLDN1 is correlated with recurrence status in breast cancer (18).…”

Section: Introductionmentioning

confidence: 99%

The expression of Claudin 1 correlates with β-catenin and is a prognostic factor of poor outcome in gastric cancer

Huang

et al. 2014

International Journal of Oncology

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Abstract. Claudin 1 is one of the tight junction proteins, which are critical in the maintenance of epithelial integrity. Aberrant regulation of CLDN1 and its correlation with β-catenin have been discovered in malignant tumors. The present study aimed to investigate the expression profile and clinical relevance of CLDN1 and β-catenin. The protein levels of CLDN1 and β-catenin were examined using immunohistochemical staining. The characteristics of expression profile and prognostic value were analyzed using Pearson's χ 2 test and Kaplan-Meier analysis, respectively. β-catenin overexpression and knockdown were used to investigate its role in regulating CLDN1 expression. We showed that CLDN1 was overexpressed in intestinal-type, presence of lymph node metastasis, higher TNM stage in gastric cancer patients and correlated with decreased overall survival. The characteristics of CLDN1 expression were associated with that of β-catenin. CLDN1 and β-catenin showed similar prognostic value in intestinal-type gastric cancers. β-catenin knockdown and overexpression in cell models revealed a positive relation between CLDN1 and β-catenin. Our study demonstrated that CLDN1 is a biomarker for intestinal-type gastric cancer with shorter survival. The expression of CLDN1 was strongly associated with β-catenin in gastric cancer patients and a gastric cancer cell model. IntroductionGastric cancer is the fourth most common cancer worldwide and is the second most common cause of cancer-related deaths.Gastric cancer has a poor prognosis (1). Although the 5-year survival rate in patients with early-stage disease is ~90%, since the vast majority present with distant metastasis, the overall 5-year survival rate is typically <20% (2). The 5-year survival rate has also been significantly correlated with the degree of tumor invasion, the presence of lymph node and/ or distant metastases and the TNM stage (3,4). However, very limited number of molecules that have clinicopathological significance in gastric cancer has been discovered.Claudin 1 (CLDN1) is one of the integral membrane proteins that constitute tight junctions. Tight junctions are essential for the tight sealing of cellular sheets and maintaining homeostasis (5). Absence of tight junctions or defective tight junctions is associated with the development of the neoplastic phenotype in epithelial cells (6). Thus it is accepted that the disruption of tight junctions leads to loss of cohesion, invasiveness and the lack of differentiation, thereby promoting tumorigenesis. CLDN1 is found to regulate intestinal epithelial homeostasis through the modulation of Notch-signaling (7). Many chemicals and nutrition can regulate CLDN1 expression through different pathways (8,9) to maintain the integrity of intestinal barrier function.The complexity of CLDN1 was proposed because its dual role as a tumor suppressor and promoter, as well as a positive and negative prognostic factor in different cancers, including breast (10,11), gastric (12), ovarian (13), lung (14) and colon (15-17). Decreased exp...

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“…Bujko et al 5 found increased CLDN1 expression in 26 samples of colorectal cancer, and 42 adenomas compared to normal colon tissue. In contrast, Ersoz et al 2 and Suren et al 10 have shown that CLDN1 expression was significantly down-regulated in a series of colon cancer tissues and this lower expression was linked to a higher proportion of lymph node metastasis or aggressive behavior of colorectal carcinoma. 2,10 This difference might be explained by the different gene expression approach used.…”

Section: Discussionmentioning

confidence: 89%

“…2 Intestinal barrier dysfunction is also an essential contributor to intestinal inflammation. 3 Structural disruption of colonic epithelial cells might impact early tumorigenesis or progression to colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of Tight Junctions and Cell Polarity Genes in Human Colon Cancer

Kourkoumpetis¹,

Royse²,

Chen³

et al. 2018

Exploratory Research and Hypothesis in Medicine

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Background and objectives: Tight junction and cell polarity proteins are paramount to epithelial cell polarity and transport. In vivo studies have shown the differential expression of tight junctions in colorectal cancer, with little to no human data to corroborate those findings. We investigated whether tight junction genes were differentially expressed in human colon cancer versus normal controls. Methods:Total RNA was extracted from fresh frozen tumor tissues and normal adjacent tissues of 6 patients who were diagnosed with primary colon cancer as well as from normal mucosa of 5 unrelated polyp-free individuals. We used the Qiagen RT 2 Profiler PCR array to determine the expression of 84 genes in the tight junction pathway. Student's t-test was used to compare gene expression levels between cancer tissues and normal mucosa using normalized gene expression data. Results:Compared with normal mucosa, significant up-regulation of the claudin 1 (CLDN1) gene (fold-change = 16, p = 0.001) but down-regulation of the AMOTL1, CLDN5, JAM2 and TIAM1 genes (fold-change > 2, p < 0.05) were seen in colon cancer tissue. Conclusions:We observed the differential expression of CLDN, AMOTL1, JAM2 and TIAM1 in colon cancer versus normal mucosa. Further larger studies are warranted to investigate the role of tight junction and cell polarity proteins in the progression of human colon tumors.

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Prognostic importance of Claudin-1 and Claudin-4 expression in colon carcinomas

Cited by 33 publications

References 22 publications

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

The expression of Claudin 1 correlates with β-catenin and is a prognostic factor of poor outcome in gastric cancer

Differential Expression of Tight Junctions and Cell Polarity Genes in Human Colon Cancer

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