Prognostic importance of central thrombus in hemodynamically stable patients with pulmonary embolism

Şentürk, Ayşegül; Özsu, Savaş; Duru, Serap; Çakır, Ebru; Ulaşlı, Sevinç Sarınç; Demirdöğen, Ezgi; Kayhan, Servet; Güzel, Aygül; Yakar, Fatih; Berk, Serdar

doi:10.5603/cj.a2017.0021

Cited by 13 publications

(10 citation statements)

References 21 publications

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“…The relationship between syncope and PTE mortality is not clear in the literature. Senturk et al reported the syncope frequency was 2‐times higher in patients with syncope despite it was not associated with the mortality . In our study, although there was a 2‐fold increase in syncope, there was no statistical difference.…”

Section: Discussioncontrasting

confidence: 65%

Syncope as a subject of the risk assessment of pulmonary thromboembolism to be used for: A cross‐sectional study

Özyurt

Özsu

Erbay

et al. 2018

Clinical Respiratory J

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Section: Discussioncontrasting

confidence: 65%

Syncope as a subject of the risk assessment of pulmonary thromboembolism to be used for: A cross‐sectional study

Özyurt

Özsu

Erbay

et al. 2018

Clinical Respiratory J

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“…The primary proposed mechanism is based on the presence of a large pulmonary artery embolus with greater than 50% occlusion of the pulmonary vascular tree accompanied by RVD and consecutively impaired left ventricular filling, leading to decreased cardiac output with arterial hypotension and declined cerebral blood flow resulting in syncope [19]. In our sample, the syncopal episode was not associated with a more central location of the thrombus load on chest CT examination, unlike other similar studies [22,23]. We, therefore, hypothesize that an equally important pathophysiological mechanism could be the partial resolution or displacement of the thrombus load, which might explain the incidence of syncope in our study population.…”

Section: Discussionmentioning

confidence: 59%

“…Thrombus localization on computed tomography of the chest was classified as peripheral (isolated lobar, segmental, and/or subsegmental arteries) or central [22].…”

Section: Definitionsmentioning

confidence: 99%

Is syncope a predictor of mortality in acute pulmonary embolism?

et al. 2019

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Whether syncope as a presenting symptom independently classifies acute pulmonary embolism (APE) into a high mortality risk group remains a matter of controversy. We retrospectively included all consecutive patients admitted to our clinic with APE from January 2014 to December 2016. Our sample consisted of 76 patients with a mean age of 69 ±13.6 years, 64.5% female. 14.3% presented with syncope at admission. In-hospital mortality was 20.8%. Patients with syncope were more likely to require inotropic support (OR = 5.2, 95 % 1.17-23.70, p=0.03) due to the association of cardiogenic shock (OR= 15.95% CI 3.02-74.32, p < 0.001) and systolic blood pressure below 90 mmHg (OR=5.52, 95% CI 1.24-24.47, p=0.03). Patients with syncope had a higher PESI score (150.9 ± 51.1 vs 99.9 ± 30.1, p < 0.001) and a greater in-hospital mortality (OR= 4.5, 95% CI 1.14-17.62, p=0.03). However, multivariate logistic regression equations did not identify syncope as an independent predictor of mortality. In our sample, syncope did not independently reclassify the patient in a higher mortality group, but due to the association with hemodynamic instability, which remains the primary tool in therapeutic decision-making.

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“…Остальные факторы, такие как ВБНК и ЗНО, выявлялись реже, в 11,4% и 6,3% случаев соответственно. Влияние на прогноз различной локализации тромбоза легочных сосудов еще требует изучения [6][7][8]. В нашем исследовании двустороннее поражение легких при ТЭЛА встречалось чаще (р<0,05) в сравнении с односторонней женщины 1 группы в сравнении с женщинами 3 группы, лицами старше 45 лет (р=0,005).…”

Section: обсуждение и результатыunclassified

Clinic Risk Factors and Peculiarities of Development of Pulmonary Embolism in Women Over the Age of 55 Years

Вардугина¹,

Вавилов²,

Ponomareva³

et al. 2017

СПНО (MPSE)

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Проанализирован 61 случай развития тромбоэмболии легочной артерии (ТЭЛА) у женщин в возрасте до 55 лет, госпитализированных в клинику. Из факторов риска у женщин с перенесенной ТЭЛА найдена большая частота ожирения (63,6%), артериальная гипертония у 52,6% лиц, и применение комбинированных оральных контрацептивов выявлено у 84,6% обследованных женщин. Осложненный акушерский анамнез (наличие выкидышей) имел место у 28,0% человек. Наличие венозного тромбоза сосудов нижних конечностей наблюдалось в 68,0% случаев. Выявлено преобладание двусторонней локализации ТЭЛА над односторонней (р<0,05). Поражение сосудов крупного калибра встречалось чаще по сравнению с сосудами II и III порядков (р<0,05). Повышение лабораторного показателя Д-димера зарегистрировано в 100,0% случаев во всех возрастных группах. Повышение тропонина наблюдалось у 50,0% женщин. Других значимых отклонений в лабораторных показателях не выявлено. Ключевые слова: тромбоэмболия легочной артерии, женщины, факторы риска. CLINIC RISK FACTORS AND PECULIARITIES OF DEVELOPMENT OF PULMONARY

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Prognostic importance of central thrombus in hemodynamically stable patients with pulmonary embolism

Abstract: The present study showed that central thrombus was not an independent predictor of mortality in hemodynamically stable PE patients. LMWH and UFH were similarly effective in the treatment of this patient group.

Cited by 13 publications

References 21 publications

Syncope as a subject of the risk assessment of pulmonary thromboembolism to be used for: A cross‐sectional study

Syncope as a subject of the risk assessment of pulmonary thromboembolism to be used for: A cross‐sectional study

Is syncope a predictor of mortality in acute pulmonary embolism?

Clinic Risk Factors and Peculiarities of Development of Pulmonary Embolism in Women Over the Age of 55 Years

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