Prognostic Importance of Atrial Fibrillation in Implantable Cardioverter-Defibrillator Patients

Borleffs, C. Jan Willem; Rees, Johannes B. van; Welsenes, Guido H. van; Velde, Enno T. van der; Erven, Lieselot van; Bax, Jeroen J.; Schalij, Martin J.

doi:10.1016/j.jacc.2009.09.053

Cited by 72 publications

(56 citation statements)

References 37 publications

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“…38, 39 Borleffs et al reported that patients with permanent AF, as compared with those without it, had a 1.7-fold risk of all-cause mortality and 2-fold risk of appropriate ICD shock during a mean 833-day follow-up after ICD implantation. 38 Similarly, the present study found that cAF was associated with a 2.9-fold increase in relative HR of FAE, defined as a composite of SCD, arrhythmic death, VT/VF and appropriate ICD therapy in group A and B patients. LV enlargement has also been reported to be a predictor of SCD in CHF, IHD with HFrEF and NIDCM patients.…”

Section: 75supporting

confidence: 76%

Current Status of Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter Defibrillator in Patients With Chronic Heart Failure

Satake

Fukuda

Sakata

et al. 2015

Circ J

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Section: 75supporting

confidence: 76%

Current Status of Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter Defibrillator in Patients With Chronic Heart Failure

Satake

Fukuda

Sakata

et al. 2015

Circ J

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“…21 Data were prospectively collected since 1996 on 913 consecutive patients receiving an ICD for primary or secondary prevention of SCD. At implantation, 73% of patients had no history of AF, 9% had a history of paroxysmal AF, 7% had a history of persistent AF, and 11% had permanent AF.…”

Section: Af and Scd In Patients With MImentioning

confidence: 99%

Atrial Fibrillation and Its Association With Sudden Cardiac Death

Chen

Benditt

Alonso

2014

Circ J

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2588CHEN LY et al. Circulation JournalOfficial Journal of the Japanese Circulation Society http://www. j-circ.or.jp are only starting to understand -SCD. We will review the evidence for an independent relationship between AF and SCD in different contexts: recipients of implantable cardioverterdefibrillators (ICDs), patients with MI, HF, or hypertension (HT), and finally, in the general population. We will also examine the determinants of SCD in patients with AF and postulate on the mechanisms underlying this novel and intriguing association. AF and Ventricular Tachyarrhythmias in Recipients of ICDsOne of the earliest lines of evidence to suggest that AF may inherently increase the incidence of ventricular tachycardia (VT) or ventricular fibrillation (VF) comes from patients who have received an ICD. In a study comprising 229 patients who received ICDs between 1995 and 1999 for secondary prevention of SCD, 19 those who had persistent AF (n=38) at the time of ICD implant experienced appropriate device therapy for recurrent ventricular tachyarrhythmias more frequently than patients who were in sinus rhythm at the time of ICD implantation (n=191) (63% vs. 38%, P=0.01). From multivariable analysis, AF was an independent predictor of both appropriate ICD therapy (relative risk 1.8; 95% confidence interval [CI] 1.2-2.9) and inappropriate device therapy (relative risk 2.3; 95% CI 1.2-4.5). Analysis of device-stored electrograms revealed a higher incidence of short-long-short cycles preceding ventricular arrhythmias in AF compared with patients in sinus trial fibrillation (AF) is the most common sustained cardiac arrhythmia, and with the aging population its prevalence is increasing over time. 1-3 Additionally, AF is associated with an increased risk of stroke, 4 heart failure (HF), 5 and death. 6-11 The Framingham Heart Study reported that AF increases the risk of death by 1.5-fold in men and 1.9-fold in women. 6 Similarly, the reported Olmsted County, Minnesota experience showed that new-onset AF doubles the risk of mortality. 7 More recently, the Women's Health Study revealed that the risk of all-cause death was doubled and cardiovascular death quadrupled by new-onset AF in initially healthy women. 8 Although the evidence for an independent association of AF with an increased risk of mortality is compelling, there are few data on the causes of death in patients with AF; the most common causes of death in the aforementioned studies were coronary artery disease (CAD) and stroke. 6,7 There is evidence from post-myocardial infarction (MI) or HF patients that AF is associated with an increased risk of sudden cardiac death (SCD). 12-14 However, SCD was not specifically reported in previous population-based studies; 6-8 hence, it is unknown whether AF increases the risk of SCD in the general population. Moreover, because AF and SCD share many common risk factors, such as HF 15,16 and CAD, 17,18 it is possible that any possible association between AF and SCD is confounded or mediated by these shared risk factors.This narrativ...

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“…Prevalent AF is associated with an increased risk of SCD in patients postmyocardial infarction 20,29,30 and in women with coronary artery disease, 31 but the relationship of SCD to AF in patients with heart failure has been inconsistent. 24,25,27 Moreover, in patients with implantable cardioverter-defibrillators (ICDs), a history of AF, 32 persistent AF at the time of ICD implantation, 33 and permanent but not persistent or paroxysmal AF, 34 have an increased risk of appropriate device therapies for ventricular arrhythmias.…”

mentioning

confidence: 99%

Relationship of Sudden Cardiac Death to New-Onset Atrial Fibrillation in Hypertensive Patients With Left Ventricular Hypertrophy

Okin

Bang

Wachtell

et al. 2013

Circ: Arrhythmia and Electrophysiology

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Prognostic Importance of Atrial Fibrillation in Implantable Cardioverter-Defibrillator Patients

Abstract: In the population currently receiving ICD treatment outside the setting of clinical trials, a large portion has either a history of AF or permanent AF. Both types of AF have prognostic implications for mortality and appropriate as well as inappropriate device discharge.

Cited by 72 publications

References 37 publications

Current Status of Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter Defibrillator in Patients With Chronic Heart Failure

Current Status of Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter Defibrillator in Patients With Chronic Heart Failure

Atrial Fibrillation and Its Association With Sudden Cardiac Death

Relationship of Sudden Cardiac Death to New-Onset Atrial Fibrillation in Hypertensive Patients With Left Ventricular Hypertrophy

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