Prognostic implications of the magnetic resonance imaging appearance in papillary renal cell carcinoma

Rosenkrantz, Andrew B.; Sekhar, Aarti; Genega, Elizabeth M.; Melamed, Jonathan; Babb, James S.; Patel, Amish; Lo, Andy Y.; Najarían, Robert M.; Ahmed, Muneeb; Pedrosa, Iván

doi:10.1007/s00330-012-2631-y

Cited by 29 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…71 Similar to previous reports, all 128 pRCCs in this study, types 1 and 2, exhibited the typical homogeneous hypovascular appearance associated with papillary tumors 52 (Fig. 5).…”

Section: Mri Phenotype Of Rccsupporting

confidence: 90%

“…The peripheral solid subelements of these masses typically demonstrate homogeneous T2 hypointensity and low-level enhancement, similar to that of entirely solid pRCC. 47,52,71 A recent study noted enhancement on MRI using subtracted postcontrast images in histologically confirmed pRCC that did not meet criteria for enhancement on multiphase CT 23 ; this observation supports a particular role for MRI over CT in the assessment of this RCC subtype given the known low-level enhancement of pRCC that may create an overlapping imaging appearance with that of a complex cyst. Detection of enhancement in pRCC is particularly challenging in hemorrhagic cystic masses.…”

Section: Mri Phenotype Of Rccmentioning

confidence: 91%

See 1 more Smart Citation

MRI Phenotype in Renal Cancer

Campbell¹,

Rosenkrantz²,

Pedrosa³

2014

Topics in Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

Renal cell carcinoma (RCC) is most commonly diagnosed as an incidental finding on cross-sectional imaging and represents a significant clinical challenge. Although most patients have a surgically curable lesion at the time of diagnosis, the variability in the biologic behavior of the different histologic subtypes and tumor grade of RCC, together with the increasing array of management options, creates uncertainty for the optimal clinical approach to individual patients. State-of-the-art magnetic resonance imaging (MRI) provides a comprehensive assessment of renal lesions that includes multiple forms of tissue contrast as well as functional parameters, which in turn provides information that helps to address this dilemma. In this article, we review this evolving and increasingly comprehensive role of MRI in the detection, characterization, perioperative evaluation, and assessment of the treatment response of renal neoplasms. We emphasize the ability of the imaging “phenotype” of renal masses on MRI to help predict the histologic subtype, grade, and clinical behavior of RCC.

show abstract

“…71 Similar to previous reports, all 128 pRCCs in this study, types 1 and 2, exhibited the typical homogeneous hypovascular appearance associated with papillary tumors 52 (Fig. 5).…”

Section: Mri Phenotype Of Rccsupporting

confidence: 90%

Section: Mri Phenotype Of Rccmentioning

confidence: 91%

MRI Phenotype in Renal Cancer

Campbell¹,

Rosenkrantz²,

Pedrosa³

2014

Topics in Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

show abstract

“…75 The latter imaging phenotype is associated with sensibly worse prognosis than that of well-defined pRCC. 74 …”

Section: ) Impact Of Imaging Methods On Patient Managementmentioning

confidence: 99%

Imaging of Solid Renal Masses

Kay

Pedrosa

2017

Radiologic Clinics of North America

Self Cite

View full text Add to dashboard Cite

Detection of solid renal masses has increased in the last decades, although it has not resulted in significant mortality reduction from renal cell carcinoma. Consequently, efforts for improved lesion characterization have been pursued and incorporated in management algorithms, in order to distinguish clinically significant tumors from favorable or benign conditions. Concurrently, imaging methods have built a broad base of evidence supporting their role as useful tools not only in lesion detection, but also characterization. In addition, newer modalities, such as contrast enhanced ultrasound, and advanced applications of magnetic resonance imaging, are being investigated. The purpose of this paper is to review the current role of different imaging methods in the characterization of solid renal masses.

show abstract

“…74 Two distinct imaging subtypes of pRCC have also been described, focal and infiltrating. 75 Infiltrating pRCC is a subtype of type 2 pRCC that carries a much worse prognosis than that of focal pRCC tumors (i.e. both pathologic type 1 or 2), and the association of an infiltrative phenotype with worse prognosis is independent of tumor size and stage.…”

Section: Clinical Applicationsmentioning

confidence: 99%

“…both pathologic type 1 or 2), and the association of an infiltrative phenotype with worse prognosis is independent of tumor size and stage. 75 Infiltrating type 2 pRCC is frequently associated with venous invasion. Regardless of its presentation, viable portions of the tumor in pRCC are almost always hypoenhancing during the corticomedullary phase (ie, approximately 20% of that of the renal cortex), 70 with rare exceptions showing enhancement approaching 50% or higher.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Role of Multiparametric MR Imaging in Malignancies of the Urogenital Tract

Leon

Costa

Pedrosa

2016

Magnetic Resonance Imaging Clinics of North America

Self Cite

View full text Add to dashboard Cite

SUMMARY mpMRI is a useful tool to depict and accentuate biophysical contrasts to yield anatomic and pathophysiologic information about GU malignancies. The role of mpMRI continues to grow due to its ability to detect and characterize GU tumors as well as assess response to treatment. Familiarity with the various imaging techniques and findings allows radiologists to have a significant impact on clinical management of patients with GU malignancies.

show abstract

Prognostic implications of the magnetic resonance imaging appearance in papillary renal cell carcinoma

Abstract: Infiltrative MRI appearance and renal vein thrombus identify a subset of pathological type 2 pRCC at a significantly increased risk of metastatic disease.

Cited by 29 publications

References 26 publications

MRI Phenotype in Renal Cancer

MRI Phenotype in Renal Cancer

Imaging of Solid Renal Masses

Role of Multiparametric MR Imaging in Malignancies of the Urogenital Tract

Contact Info

Product

Resources

About