Prognostic Implications of the High-Sensitive C-Reactive Protein in the Catheter Ablation of Atrial Fibrillation

Lin, Yenn Jiang; Tsao, Hsuan Ming; Chang, Shih Lin; Lo, Li Wei; Tuan, Ta Chuan; Hu, Yu Feng; Udyavar, Ameya R.; Tsai, Wen‐Liang; Chang, Chien Jung; Tai, Ching Tai; Lee, Pi Chang; Suenari, Kazuyoshi; Huang, Shih-Horng; Tung, Nguyen Hưu; Chen, Shih Ann

doi:10.1016/j.amjcard.2009.10.019

Cited by 80 publications

(60 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11 In this study, we did not find a significant relationship between the baseline inflammatory state and the extent of elevation in the markers of inflammation and myocardial injury, and AF recurrence at 6 months. However, our study found that the degree of inflammatory response after ablation (extent of hs-CRP elevation) was significantly associated with early AF recurrence within 3 days after procedure.…”

Section: Inflammation and Af Recurrencementioning

confidence: 62%

“…7,8 Studies linking inflammation levels at baseline and after ablation with early and late AF recurrences after ablation have yielded varying results. 4,7,[9][10][11] To date, the specific time course of inflammation, myocardial injury, and prothrombotic markers after RF ablation for AF has not been well defined. We aimed to investigate the inflammatory response after ablation and its relation to AF recurrence and to examine the relationship between inflammation and prothrombotic risk after ablation.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Time Course of Inflammation, Myocardial Injury, and Prothrombotic Response After Radiofrequency Catheter Ablation for Atrial Fibrillation

Lim

Schultz

Dang

et al. 2014

Circ: Arrhythmia and Electrophysiology

135

108

View full text Add to dashboard Cite

Ninety consecutive patients undergoing elective RF catheter ablation for AF were prospectively studied. All patients >18 years old, with a © 2014 American Heart Association, Inc. Original ArticleBackground-Inflammation has been linked to the genesis of stroke in atrial fibrillation (AF) and is implicated in early recurrent arrhythmia after AF ablation. We aimed to define the time course of inflammation, myocardial injury, and prothrombotic markers after radiofrequency ablation for AF and its relation to AF recurrence. Methods and Results-Ninety consecutive AF patients (53% paroxysmal) undergoing radiofrequency ablation were recruited. High-sensitivity C-reactive protein (hs-CRP), Troponin-T, creatine kinase-MB, fibrinogen, and D-Dimer concentrations were measured at baseline, at 1, 2, 3, 7 days, and at 1 month after ablation. AF recurrence was documented at 3 days and at 1, 3, and 6 months follow-up. Troponin-T and creatine kinase-MB peaked at day 1 after procedure (both P<0.05). Hs-CRP peaked at day 3 after procedure (P<0.05). Fibrinogen (P<0.05) and D-Dimer (P<0.05) concentrations were significantly elevated at 1 week after procedure. Ln hs-CRP elevation correlated with Ln Troponin-T and fibrinogen elevation. The extent of Ln hs-CRP, Ln Troponin-T, and fibrinogen elevation predicted early AF recurrence within 3 days after procedure (P<0.05, respectively), but not at 3 and 6 months. Conclusions-Patients undergoing radiofrequency ablation for AF exhibit an inflammatory response within 3 days. The extent of inflammatory response predicts early AF recurrence but not late recurrence. Prothrombotic markers are elevated at 1 week after ablation and may contribute to increased risk of early thrombotic events after AF ablation. (Circ Arrhythm Electrophysiol. 2014;7:83-89.)

show abstract

Section: Inflammation and Af Recurrencementioning

confidence: 62%

mentioning

confidence: 99%

Time Course of Inflammation, Myocardial Injury, and Prothrombotic Response After Radiofrequency Catheter Ablation for Atrial Fibrillation

Lim

Schultz

Dang

et al. 2014

Circ: Arrhythmia and Electrophysiology

135

108

View full text Add to dashboard Cite

show abstract

“…29, 30 Our previous study has demonstrated that patients with a high CRP level were associated with an abnormal LA substrate and poor outcome after catheter ablation of AF. 31 Therefore, the inflammatory process occurring from the early stage of renal dysfunction might result in atrial remodeling and a subsequent occurrence of AF and poor outcome after the catheter ablation.…”

Section: Renal Function and Af Recurrence After Catheter Ablationmentioning

confidence: 99%

Associations Between Renal Function, Atrial Substrate Properties and Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Chao

Lin

Chang

et al. 2011

Circ J

Self Cite

View full text Add to dashboard Cite

Background: Renal dysfunction was reported to be associated with a higher recurrence rate after electric cardioversion of atrial fibrillation (AF). The aim of this study was to investigate the associations between renal function, atrial substrate properties and outcome of catheter ablation in paroxysmal AF patients. Methods and Results:A total of 232 paroxysmal AF patients that underwent catheter ablation were enrolled in the study. The estimated glomerular filtration rate (GFR) was calculated using the Cockcroft-Gaut equation normalized by the body surface area, and the patients were divided into 3 groups according to their GFR (group 1: ≥90 ml · min -1 · 1.73 m -2 , group 2: 60-90 ml · min -1 · 1.73 m -2 and group 3: <60 ml · min -1 · 1.73 m -2 ). The left atrial (LA) voltage became lower and the activation time longer when the GFR decreased from group 1 to group 3. During a follow up of 25.4±13.3 months, 15.9% of the study population suffered from AF recurrences. The recurrence rates of those 3 groups were 6.9%, 14.5% and 38.9%, respectively. The LA dimension, LA voltage and groups of renal function were identified to be the independent predictors of an AF recurrence in the multivariate analysis. Conclusions:A decreased GFR was associated with an abnormal LA substrate and high recurrence rate of catheter ablation in patients with paroxysmal AF. (Circ J 2011; 75: 2326 - 2332

show abstract

“…Other investigators found correlation between baseline CRP levels and the risk of recurrent AF after ablation attempts by circumferential pulmonary vein isolation 27 and catheter ablation. 26 Inflammation might be involved in the prothrombotic state during AF. 54 Inf lammatory cells such as monocytes, macrophages, and lymphocytes produce cytokines and chemokines and can trigger and sustain thrombosis in AF.…”

Section: Correlation Between Atrial Fibrillation and Inflammationmentioning

confidence: 99%

Inflammation and C-Reactive Protein in Atrial Fibrillation: Cause or Effect?

Galea¹,

Cardillo²,

Caroli³

et al. 2014

Texas Heart Institute Journal

View full text Add to dashboard Cite

show abstract

Prognostic Implications of the High-Sensitive C-Reactive Protein in the Catheter Ablation of Atrial Fibrillation

Cited by 80 publications

References 26 publications

Time Course of Inflammation, Myocardial Injury, and Prothrombotic Response After Radiofrequency Catheter Ablation for Atrial Fibrillation

Time Course of Inflammation, Myocardial Injury, and Prothrombotic Response After Radiofrequency Catheter Ablation for Atrial Fibrillation

Associations Between Renal Function, Atrial Substrate Properties and Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Inflammation and C-Reactive Protein in Atrial Fibrillation: Cause or Effect?

Contact Info

Product

Resources

About