Prognostic implications of Tc-99m sestamibi viability imaging and subsequent therapeutic strategy in patients with chronic coronary artery disease and left ventricular dysfunction

Sciagra, R.; Pellegri, M.; Pupi, Alberto; Bolognese, L.; Bisi, G.; Carnovale, V.; Santoro, G.M.

doi:10.1016/s1062-1458(00)00176-8

Cited by 15 publications

(16 citation statements)

References 29 publications

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“…4 The most important factor for successful surgical recovery may be the viability of revascularized myocardium. [11][12][13][14] Therefore, preoperative investigations should include transthoracic echocardiography to grossly evaluate ventricular function, and nuclear studies or dobutamine stress echocardiography to identify the reversibility of myocardial ischemia. In addition, coronary angiography is needed to define the affected territory.…”

Section: Discussionmentioning

confidence: 99%

Clinical Results of Coronary Revascularization in Left Ventricular Dysfunction

Lee

Chang

Yoo

et al. 2007

Circ J

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DefinitionsThe number of diseased vessels was defined as the number of the 3 major coronary perfusion territories affected. Perioperative insertion of an intra-aortic balloon pump (IABP) was defined as a procedure for improving hemodynamics in the presence of cardiogenic shock. Postoperative cerebrovascular accident (CVA) was defined as a focal or global neurological deficit confirmed by a neurologist.

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Section: Discussionmentioning

confidence: 99%

Clinical Results of Coronary Revascularization in Left Ventricular Dysfunction

Lee

Chang

Yoo

et al. 2007

Circ J

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“…Similar to 201 Tl, uptake of these agents provides information on both myocardial perfusion and viability. 39 However, compared with 201 Tl, the 99m Tc-labeled tracers undergo much less redistribution with time. They emit higher-energy photons than 201 Tl, which are ideal for SPECT and are subjected to a reduced amount of soft-tissue attenuation.…”

Section: Assessment Of Viabilitymentioning

confidence: 99%

Stunning, Hibernation, and Assessment of Myocardial Viability

2008

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“…Thus far, one study in which sestamibi imaging was used to evaluate long-term prognosis for patients with ischemic cardiomyopathy has been published (40). Sciagra et al (40) evaluated 105 patients with chronic coronary artery disease and LV dysfunction; all underwent nitrate-enhanced sestamibi imaging. The patients were accordingly divided into 3 groups: medical treatment, complete revascularization, and incomplete revascularization.…”

Section: Nuclear Imaging By Pet With 18 F-fdgmentioning

confidence: 99%

Assessment of Myocardial Viability in Patients with Heart Failure

Schinkel¹,

Poldermans²,

Elhendy³

et al. 2007

Journal of Nuclear Medicine

132

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The prognosis for patients with chronic ischemic left ventricular dysfunction is poor, despite advances in different therapies. Noninvasive assessment of myocardial viability may guide patient management. Multiple imaging techniques have been developed to assess viable and nonviable myocardium by evaluating perfusion, cell membrane integrity, mitochondria, glucose metabolism, scar tissue, and contractile reserve. PET, 201 Tl and 99m Tc scintigraphy, and dobutamine stress echocardiography have been extensively evaluated for assessment of viability and prediction of clinical outcome after coronary revascularization. In general, nuclear imaging techniques have a high sensitivity for the detection of viability, whereas techniques evaluating contractile reserve have a somewhat lower sensitivity and a higher specificity. MRI has a high diagnostic accuracy for assessment of the transmural extent of myocardial scar tissue. Patients with a substantial amount of dysfunctional but viable myocardium are likely to benefit from coronary revascularization and may show improvements in regional and global contractile function, symptoms, exercise capacity, and long-term prognosis.

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Prognostic implications of Tc-99m sestamibi viability imaging and subsequent therapeutic strategy in patients with chronic coronary artery disease and left ventricular dysfunction

Cited by 15 publications

References 29 publications

Clinical Results of Coronary Revascularization in Left Ventricular Dysfunction

Clinical Results of Coronary Revascularization in Left Ventricular Dysfunction

Stunning, Hibernation, and Assessment of Myocardial Viability

Assessment of Myocardial Viability in Patients with Heart Failure

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