Prognostic implications of synaptophysin, CD56, thyroid transcription factor-1, and Ki-67 in pulmonary high-grade neuroendocrine carcinomas

He, Yulong; Zhao, Lei; Tang, Xiaorong; Jiang, Qinling; Zhao, Xianling; Cao, Yilin

doi:10.1016/j.anndiagpath.2023.152239

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2024

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“…Thymic carcinoma is positive for CK5 and CD117 immunoreactivity ( 16 ). Established IHC markers for diagnosing neuroendocrine tumor neoplasms include Syn, CD56 and TTF-1, which demonstrate notable sensitivity and specificity in their diagnostic utility ( 17 – 19 ). IHC staining for GATA3 in mediastinal masses is not routinely performed by the Affiliated Hospital of Weifang Medical University (Weifang, China).…”

Section: Discussionmentioning

confidence: 99%

Occult urothelial carcinoma with mediastinal metastasis: A case report

Zheng,

Peng,

et al. 2024

Oncol Lett

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Occult urothelial carcinoma (UC), particularly with mediastinal metastases, is an uncommon clinical occurrence. The present study describes the unusual case of a 70-year-old male patient who developed mediastinal metastases from an occult UC. Histological evaluations and immunohistochemical features of the mediastinal tumor were indicative of UC; however, extensive imaging failed to identify the primary urological lesion. The findings suggest that mediastinal metastases from UCs, despite their rarity, should be considered in cases where patients with mediastinal tumors exhibit chest-related symptoms. Prompt pathological examinations are crucial for ascertaining the nature and origin of the tumor. Moreover, individualized treatment should be performed in strict accordance with the established oncology guidelines.

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Section: Discussionmentioning

confidence: 99%