Prognostic implications of preoperative chronic kidney disease and anemia in patients undergoing coronary artery bypass graft surgery

Ogami, Takuya; Matsue, Yuya; Kawasumi, Ryo; Tanabe, Hiroaki

doi:10.1007/s00595-016-1368-7

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…3). Similar correlation was previously reported in the analysis of the influence of CKD and anaemia in a younger population (median age 71.1 years), but the association was observed only when both parameters coexisted [14]. The issue of CKD is also well described in the literature regarding the impact on in-hospital mortality [13], and the individuals are at high risk of cardiovascular events even when not undergoing interventional treatment or despite the revascularisation method applied [15].…”

Section: Discussionsupporting

confidence: 79%

How to predict the risk of postoperative complications after coronary artery bypass grafting in patients under 50 and over 80 years old. A retrospective cross-sectional study

Piątek

Kędziora

Kiełbasa³

et al. 2017

Kardiol Pol

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Section: Discussionsupporting

confidence: 79%

How to predict the risk of postoperative complications after coronary artery bypass grafting in patients under 50 and over 80 years old. A retrospective cross-sectional study

Piątek

Kędziora

Kiełbasa³

et al. 2017

Kardiol Pol

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“…Although anemia was thoroughly discussed in the literature as an important risk factor for in-hospital mortality after CABG, [13][14][15][21][22][23][24][25][26][27][28][29][30][31] the difference in normal Hb levels was not evaluated before.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, patients with lower limits of normal Hb levels were at greater risk compared with mid‐normal values. Although anemia was thoroughly discussed in the literature as an important risk factor for in‐hospital mortality after CABG, 13 , 14 , 15 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 the difference in normal Hb levels was not evaluated before.…”

Section: Discussionmentioning

confidence: 99%

Mortality across the spectrum of hemoglobin level in patients undergoing surgical coronary revascularization

Khalaji

Ajam

Sheikhy

et al. 2023

Clinical Cardiology

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Background Preoperative hemoglobin (Hb) level is a predictor of in‐hospital and midterm mortality in patients undergoing coronary artery bypass grafting surgery (CABG). However, the debate about the different hazards across Hb levels and sex differences in outcome occurrence is still on the table. Methods This is a registry‐based serial cross‐sectional study at Tehran Heart Center. Nonanemic patients who underwent CABG with complete follow‐up data were included. The Restricted Cubic Splines (RCS) in the Cox model was used to calculate the sex‐specific correlation between in‐hospital, 6‐month, and 1‐year mortalities and normal Hb levels using odds ratio for the in‐hospital and hazard ratios for 6‐month and 1‐year mortality, adjusted for all possible confounders. Results From 2005 to 2016, a total of 13,557 patients were included, of which 134 had in‐hospital mortality as our primary outcome. Preoperative Hb levels were significantly lower in the deceased. Moreover, dead patients had significantly higher rates of diabetes and hypertension, while lower ejection fraction. Cut‐offs for reference Hb level were higher for males compared with females. The correlation between Hb level and in‐hospital mortality was nearly U‐shaped. Quantitatively, Hb of ≥15.62 and ≤13.25 g/dL for men and that of ≥14.92 and ≤13.4 g/dL for women tended to be associated with higher in‐hospital mortality. Conclusions The association between preoperative Hb level and in‐hospital mortality differs in men and women and does not follow a linear correlation among nonanemic patients. Both low and high numbers in the Hb level spectrum are at greater risk.

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“…Prognosis worsened when major bleeding or preoperative chronic kidney disease were associated with anemia and/or transfusion. [42]. Thus, preoperative correction of iron deficiency by intravenous iron might be beneficial through the correction of ID per se or through the correction of anemia [43].…”

Section: Cardiac Surgerymentioning

confidence: 99%

Iron deficiency from the standpoint of cardiac rehabilitation: novel therapeutic opportunities

Malfatto

Frisinghelli²,

Ambrosetti

et al. 2019

Monaldi Arch Chest Dis

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Anemia is one of the most frequent comorbidities found in patients with coronary artery disease and chronic heart failure (CHF) who are being followed in cardiac rehabilitation facilities. The more frequent type of anemia is caused by iron deficiency (IDA, iron-deficiency anemia): this review summarizes the state of the art of this topic. First of all, the mechanisms of IDA will be analyzed. Subsequently, a description of the main conditions where IDA can unfavorably affect the clinical course, and of its more frequent complications, will be presented (percutaneous interventions, heart surgery, CHF). Special attention will be paid in the description of anemia in the setting of CHF. To this regard, in recent years a relevant amount of research has been carried out, to determine whether treating anemia (either by directly stimulating erythropoiesis or by correcting iron deficiency by oral or intravenous route) is of any clinical and prognostic relevance in patients with CHF. The results of this research will, therefore, be summarized and critically discussed. Finally, we will outline the promising role of cardiac rehabilitation facilities and of its network of experts in the diagnosis, prognostic stratification, and treatment of anemia and iron deficiency.

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Prognostic implications of preoperative chronic kidney disease and anemia in patients undergoing coronary artery bypass graft surgery

Abstract: The presence of both CKD and anemia in patients undergoing CABG for coronary artery disease is synergistically associated with a worse outcome.

Cited by 6 publications

References 33 publications

How to predict the risk of postoperative complications after coronary artery bypass grafting in patients under 50 and over 80 years old. A retrospective cross-sectional study

How to predict the risk of postoperative complications after coronary artery bypass grafting in patients under 50 and over 80 years old. A retrospective cross-sectional study

Mortality across the spectrum of hemoglobin level in patients undergoing surgical coronary revascularization

Iron deficiency from the standpoint of cardiac rehabilitation: novel therapeutic opportunities

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