Prognostic Implications of Nodal Yield in Rectal Cancer After Neoadjuvant Therapy: Is Nodal Yield Still Relevant Post Neoadjuvant Therapy?

Abdulla, Faheem Ahmed; Wagh, Mira; Muralee, Madhu; Mathew, Arun Peter; Bharath, V; Saxena, Renu; George, Preethi S.; Chandramohan, K

doi:10.1007/s12262-021-03154-w

Cited by 1 publication

(7 citation statements)

References 24 publications

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“…In the systematic review, six articles showed that tumour location was not significantly associated with the LN yield in colorectal cancer25 26 35 40 64 65; however, four articles revealed association, without explaining the specific association 5 34 36 63. Ten articles revealed that more LNs could be obtained from the right colon than the other locations 21 22 25 29 31 37 39 41 44 48.…”

Section: Resultsmentioning

confidence: 98%

“…In the systematic review, nine studies indicated no significant association between the degree of tumour differentiation and number of retrieved LNs 21 29 39 41 47 53 54 59 65. However, three studies suggested that more LNs could be obtained from poorly differentiated cancer 43 50 63.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, 54 studies were included, with 30 included in the systematic review,5 19–47 and 24 in the meta-analysis (figure 1). 12–14 48–68…”

Section: Resultsmentioning

confidence: 99%

“…In the systematic review, 20 articles revealed no significant association between age and the retrieval of LNs in colorectal cancer 21–23 26 27 30 32 35 37–41 47–49 54 55 64 65. However, 18 articles indicated that more LNs were obtained from young patients than elderly patients (online supplemental table 6).…”

Section: Resultsmentioning

confidence: 99%

“…The analysis of gender and retrieved LNs in colorectal cancer using systematic review included ten colorectal cancer,21 26 27 31 32 36 37 39 41 51 five colon cancer22 30 35 44 47 and five rectal cancer studies 23 38 42 54 65. These studies showed that gender had no significant association with the LN yield.…”

Section: Resultsmentioning

confidence: 99%

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Association between the number of retrieved lymph nodes and demographic/tumour-related characteristics in colorectal cancer: a systematic review and meta-analysis

Liu,

Huang,

Yang

et al. 2023

BMJ Open

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ObjectiveClinical practice guidelines recommend retrieving at least 12 lymph nodes for correct staging in colorectal cancer. However, it is difficult to retrieve adequate lymph nodes because of various factors. We aimed to evaluate the association between the number of retrieved lymph nodes and demographic/tumour-related characteristics in colorectal cancer.DesignSystematic review and meta-analysis of primary studies.Data sourcesPubMed, Embase, Cochrane and Web of Science were searched from January 2016 to June 2023.Eligibility criteria for selecting studiesStudies that evaluated the association between retrieved lymph nodes and demographic/tumour-related characteristics in colorectal cancer were included.Data extraction and synthesisOR with 95% conference intervals was extracted and pooled.ResultsA total of 54 studies containing 2 05 821 patients were included in this meta-analysis. The results showed that fewer nodes were retrieved from elderly patients (OR=0.70, 95% CI (0.54 to 0.90), p=0.005), and from tumours located in the left colon than in the right colon (OR=0.43, 95% CI (0.33 to 0.56), p<0.001). More lymph nodes were obtained from females than males (OR=1.15, 95% CI (1.04 to 1.28), p=0.006), from the advanced T stage (T3+T4) than T1+T2 stage (OR=1.57, 95% CI (1.25 to 1.97), p<0.001) and from the N2 stage than N0 stage (OR=1.32, 95% CI (1.15 to 1.51), p<0.001). Body mass index, ethnicity, N1 stage, M stage, tumour differentiation and lymph–vascular invasion were not significantly associated with the lymph node yield.ConclusionsThe study results suggest that clinicians have an increased opportunity to retrieve sufficient lymph nodes for accurate pathological staging to guide treatment decisions in patients with colorectal cancer who are young, female, with tumours located in the right colon, advanced T stage and N2 stage.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

“…Finally, 54 studies were included, with 30 included in the systematic review,5 19–47 and 24 in the meta-analysis (figure 1). 12–14 48–68…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%