Prognostic Implications of Left Atrial Volume Index in Patients in Sinus Rhythm

Leung, Dominic Y.; Chi, Cecilia; Allman, Christine; Boyd, Anita; Ng, Arnold C.T.; Kadappu, K.; Leung, Melissa; Thomas, Liza

doi:10.1016/j.amjcard.2010.01.027

Cited by 53 publications

(35 citation statements)

References 18 publications

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“…Other studies have shown that left atrial enlargement, mainly determined by the left atrial volume index (LAVi) is a predictor of cardiovascular events such as mortality; HF; hospitalization; need for heart transplantation; higher incidence of cerebrovascular accident (CVA) and atrial fibrillation; acute myocardial infarction; and coronary artery bypass surgery [14][15][16][17] . Considering the HF picture, the prognostic studies on P-wave measurements in conjunction with those of the left atrium are scarce 11,18 , which motivated the present study.…”

Section: Introductionmentioning

confidence: 99%

Dispersão da onda P e índice de volume do átrio esquerdo como preditores na insuficiência cardíaca

Silva¹,

N²,

Torres³

et al. 2013

Arq. Bras. Cardiol.

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Section: Introductionmentioning

confidence: 99%

Dispersão da onda P e índice de volume do átrio esquerdo como preditores na insuficiência cardíaca

Silva¹,

N²,

Torres³

et al. 2013

Arq. Bras. Cardiol.

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“…In our study, the incidence of new-onset AF in HF was still high, even during optimal medical therapy, and occurred in 29.2% of the patients after a mean follow-up of 35.7±11.2 months. To enable the prevention of AF, risk stratification on the basis of large observational studies has shown that several parameters are associated with AF [8][9][10][11][12][13][14][15][16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

“…The identification of individuals at risk for AF remains a challenge, though. Therefore, risk stratification based on clinical, biomarkers and echocardiographic parameters to define patients who are at risk for AF has been studied extensively [8][9][10][11][12][13][14][15][16][17][18] . With its ability to identify or exclude abnormalities in cardiac structure and function, echocardiography could be useful for prediction of future…”

Section: Introductionmentioning

confidence: 99%

Um novo índice de doppler tecidual para a predição de fibrilação atrial futura em pacientes com insuficiência cardíaca

Mornos

Petrescu

Cozma

et al. 2011

Arq. Bras. Cardiol.

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“…Num estudo publicado, o VAE foi um fator preditor independente de morte cardiovascular, insuficiência cardíaca, fibrilhação auricular e acidente vascular cerebral numa amostra de 483 indivíduos não selecionados em ritmo sinusal e um seguimento médio de aproximadamente sete anos 4 . No entanto, o seu valor prognóstico em doentes com MCD ainda está pouco estudado.…”

Section: Introductionunclassified

O volume da aurícula esquerda como marcador ecocardiográfico de prognóstico em doentes com miocardiopatia dilatada

Ferreira¹,

Galrinho²,

Soares³

et al. 2013

Revista Portuguesa de Cardiologia

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Durante o seguimento, oito doentes morreram, um foi colocado em AVM e um foi transplantado. A análise de Cox univariável revelou potenciais marcadores ecocardiográficos de prognóstico na amostra tais como a dimensão da AE em modo M (HR-1,12; IC: 0,99-1,26; p = 0,067); VAE (HR-1,02; IC: 1,00-1,04; p = 0,046); VAE ajustado à superfície corporal (HR-1,03; IC: 1,00-1,07; p = 0,049); E/A (HR-0,99; IC: 0,99-1,81; p = 0,060); E/A > 2 (HR-7,00; IC:1,48-32,43; p = 0,014) e E/E' mitral (HR-1,04; IC: 1,00-1,09; p = 0,074). Na análise multivariável a única variável que permaneceu no modelo foi o VAE com o ponto de corte de 63 ml 7, IC: 0,61, p = 0,05 Objective: To evaluate the long-term prognostic value of LA volume (LAV) in patients with DCM. Methods: We prospectively studied patients admitted from January to December 2004 with a diagnosis of DCM, in sinus rhythm. Complete echocardiographic study at rest and after pharmacological stress was performed in all patients. The composite endpoint of mechanical ventricular assistance (MVA), heart transplantation or death during follow-up was assessed by univariate and multivariate analysis using a Cox regression model. Results: The study population consisted of 35 patients (68.6% male, mean age 52.0) with DCM, 82.9% of non-ischemic etiology. Ejection fraction (EF) at rest was 31.1±9.4%.During follow-up, eight patients died, one was placed on MVA and one underwent transplantation. Univariate Cox analysis showed various potential echocardiographic markers of prognosis in our population, including LA size in M-mode (HR 1.12, CI: 0.99-1.26, p=0.067), LAV (HR 1.03, CI: 1.00-1.07, p=0.046), LAV adjusted for body surface area (HR 1.03, CI: 0.99-1.26, p=0.049), E/A ratio (HR 0.99; CI: 0.99-1.81; p=0.060); E/A >2 (HR 7.00, CI: 1.48-32.43, p=0.014) and mitral E/E' ratio (HR 1.04, CI: 1.00-1.09, p=0.074).The only variable that remained in the multivariate model was LAV, with a cut-off value of 63 ml (HR 7.7, p=0.05). Conclusions: LAV was the only echocardiographic determinant of MVA, heart transplantation or death in our population with DCM. The echocardiographic parameters commonly used for risk stratification such as EF, left ventricular end-diastolic diameter and contractile reserve did not show prognostic significance in our study.

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Prognostic Implications of Left Atrial Volume Index in Patients in Sinus Rhythm

Cited by 53 publications

References 18 publications

Dispersão da onda P e índice de volume do átrio esquerdo como preditores na insuficiência cardíaca

Dispersão da onda P e índice de volume do átrio esquerdo como preditores na insuficiência cardíaca

Um novo índice de doppler tecidual para a predição de fibrilação atrial futura em pacientes com insuficiência cardíaca

O volume da aurícula esquerda como marcador ecocardiográfico de prognóstico em doentes com miocardiopatia dilatada

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