Prognostic implications of human papillomavirus status for patients with non-oropharyngeal head and neck squamous cell carcinomas

Abstract

Patients with HPV-positive non-OPSCC exhibit similar characteristics as HPV-positive OPSCC. Overall survival was significantly higher for patients with HPV-positive versus HPV-negative non-OPSCC. These data reveal that HPV-positive non-OPSCC represent a favorable cohort that warrants recognition in the design of future clinical trial investigation.

P16 positivity and regression grade predict survival after neoadjuvant radiotherapy of OSCC

“…(), 19.993 patients treated between 2004 and 2012 with non‐OPSCC and known HPV status (American Cancer Society, National Cancer Database) were analysed, of which 25.3% were HPV positive. Interestingly, in the subset of oral cavity (OSCC) tumours, which comprised 63.9% of the whole collective, 33.5% were HPV positive (Ko et al., ). The authors found that overall survival was significantly higher in the HPV‐positive group.…”

HPV impacts survival of stage IVC non-oropharyngeal HNSCC cancer patients

“…Differences in baseline patient characteristics between individuals with non-metastatic HPV-positive and HPV-negative OPSCC are well established and have recently been described for those with non-OPSCC [ 5 , 10 , 14 , 17 ]. Here, these differences were maintained in patients presenting with Stage IVC non-OPSCC.…”

“…Patients with non-metastatic HPV-positive OPSCC or non-OPSCC commonly present with smaller primary tumors and harbor more extensive adenopathy compared to patients with HPV-negative disease [ 5 , 10 , 14 , 17 ]. Though there was a statistically significant distribution favoring higher T-stages in the HPV-negative cohort, the majority of patients, regardless of HPV-status, were diagnosed with ≥ T2 and ≥ N2b disease suggesting that both patient cohorts presented with advanced locoregional disease.…”

“…Non-metastatic HPV-positive non-OPSCC patients exhibit improved outcomes compared to similar patients with HPV-negative disease [ 10 - 14 ]. Here, we demonstrate that patients with Stage IVC HPV-positive non-OPSCC exhibit a similar improvement in overall survival.…”

“…We recently reported outcomes for patients identified in the National Cancer Database (NCDB) with early stage and locally advanced HPV-negative and HPV-positive non-OPSCC [ 14 ]. Adjusted 3-year overall survival for HPV-negative and HPV-positive non-OPSCC was 62% and 80%, respectively.…”