2017
DOI: 10.1016/j.wneu.2017.04.035
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Prognostic Implications of Extent of Resection in Glioblastoma: Analysis from a Large Database

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Cited by 74 publications
(32 citation statements)
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References 18 publications
(22 reference statements)
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“…This is in agreement with previous studies 16 , 17 . Patients who underwent total or subtotal resection lived longer, also in line with previously reported 18 , 19 . The survival was significantly shorter the worse patients’ general health status at diagnosis.…”
Section: Discussionsupporting
confidence: 88%
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“…This is in agreement with previous studies 16 , 17 . Patients who underwent total or subtotal resection lived longer, also in line with previously reported 18 , 19 . The survival was significantly shorter the worse patients’ general health status at diagnosis.…”
Section: Discussionsupporting
confidence: 88%
“…One hypothesis would be that the activity of MGMT promoter methylation is cancelled out by other yet unidentified effects. For example, it is known that epigenetic silencing of MGMT may have tumour-inducing effect 19 , and this could explain the lack of differences in our cohort. Another potential explanation for our results is that the regulation of MGMT methylation differs in our cohort.…”
Section: Discussionmentioning
confidence: 87%
“…Temozolomide treatment is more effective in female compared to male GBM patients Sex differences in GBM incidence have been repeatedly reported (5,(7)(8)(9)(10)(11). Moreover, several recent studies have suggested that being female is associated with better outcome from GBM in both adults and children (8)(9)(10)19). The introduction of temozolomide as a component of tri-modal care for adults with GBM has improved outcomes somewhat and highlighted factors, like MGMT promoter methylation, that significantly impact on response and survival (20,21).…”
Section: Resultsmentioning
confidence: 99%
“…While low-grade glioma incidence is nearly identical in males and females, malignant brain tumors in general occur more commonly in males, regardless of patient age or geographical location (6,15) (5,11). From multiple recent reports, GBM occurs with a male to female ratio of 1.6:1 (5,(8)(9)(10). More specifically, while concepts of molecular subtypes of GBM are still evolving (16), of the four originally described transcriptional subtypes of GBM, three -Mesenchymal, Proneural and Neural GBM -exhibit a 2:1 male to female incidence ratio, while Classical GBM occurs with equal incidence (17,18).…”
mentioning
confidence: 99%
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