Prognostic Implications of Endoscopic Obstruction in Patients with Pathological Stage II Colon Cancers: a Single-Center Retrospective Cohort Study

Mo, Tai‐Wei; Zhang, Zong-Jin; Shi, Yaqian; Xiang, Hai-Dong; Chen, Yongle; Hu, Jiancong; He, Xiaowen

doi:10.1007/s11605-022-05516-5

Cited by 2 publications

(1 citation statement)

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“…The occurrence of endoscopic obstruction (eOB) in individuals with colorectal cancer is not uncommon ( 4 ), and eOB is defined as the inability of standard colonoscopy to penetrate the tumor, regardless of clinical signs of intestinal obstruction (abdominal distention, peristalsis abdominal pain, nausea, or vomiting) or imaging findings of intestinal obstruction (dilated intestinal loops). Meanwhile, recent studies indicate that eOB is a marker of poor prognosis in patients with stage II colon cancer and stage III rectal cancer following curative surgery ( 5 , 6 ). Therefore, early identification of eOB is critical for the patient’s treatment.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic obstruction predominantly occurs in right-side colon cancer and endoscopic obstruction with tumor size ≤ 5 cm seems poor prognosis in colorectal cancer

Yu,

Lin,

Wang

et al. 2024

Front. Oncol.

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BackgroundEndoscopic obstruction (eOB) is associated with a poor prognosis in colorectal cancer (CRC). Our study aimed to investigate the association between tumor location and eOB, as well as the prognostic differences among non-endoscopic obstruction (N-eOB), eOB with tumor size ≤ 5 cm, and eOB with tumor size > 5 cm in non-elderly patients.MethodsWe retrospectively reviewed the clinicopathological variables of 230 patients with CRC who underwent curative surgery. The multivariable logistic regression model was used to identify risk factors for eOB. The association between eOB with tumor size ≤ 5 cm and disease-free survival (DFS) was evaluated using multivariate cox regression analysis.ResultsA total of 87 patients had eOB while 143 had N-eOB. In multivariate analysis, preoperative carcinoembryonic antigen (p = 0.014), tumor size (p = 0.010), tumor location (left-side colon; p = 0.033; rectum; p < 0.001), and pT stage (T3, p = 0.009; T4, p < 0.001) were significant factors of eOB. The DFS rate for eOB with tumor size ≤ 5 cm was significantly lower (p < 0.001) in survival analysis. The eOB with tumor size ≤ 5 cm (p = 0.012) was an unfavorable independent factor for DFS.ConclusionsThe patients with eOB were significantly associated with right-side colon cancer as opposed to left-side colon cancer and rectal cancer. The eOB with tumor size ≤ 5 cm was an independent poor prognostic factor. Further studies are needed to target these high-risk groups.

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Section: Introductionmentioning

confidence: 99%