Prognostic Implications of Coronary Flow Reserve on Left Anterior Descending Coronary Artery in Hypertrophic Cardiomyopathy

Cortigiani, Lauro; Rigo, Fausto; Gherardi, Sonia; Galderisi, Maurizio; Sicari, Rosa; Picaño, Eugenio

doi:10.1016/j.amjcard.2008.08.023

Cited by 74 publications

(60 citation statements)

References 30 publications

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“…CFR in left anterior descending coronary artery is markedly lower in patients with HCM than in healthy subjects and it has proven to be a strong prognostic predictor in patients with HCM [17].…”

Section: Discussion and Reviewmentioning

confidence: 99%

Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance

Gutiérrez-Barrios

Camacho-Jurado²,

Díaz‐Retamino

et al. 2015

Cardiovascular Revascularization Medicine

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Section: Discussion and Reviewmentioning

confidence: 99%

Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance

Gutiérrez-Barrios

Camacho-Jurado²,

Díaz‐Retamino

et al. 2015

Cardiovascular Revascularization Medicine

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“…The additive prognostic value of simultaneously evaluated CFR and wall motion abnormalities [3,[21][22][23][24], aortic distensibility indices [25], or grade of AA [26] was also demonstrated. Moreover, CFR was found to be predictive for future events in hypertensives [27], AS [6], dilated [28][29][30] and hypertrophic cardiomyopathies [5,31], in renal transplant recipients [32] and after heart transplantation [33], as well. Gender differences [24], and the prognostic value of CFR assessments on both left and right coronary arteries has also been examined [23,30].…”

Section: Discussionmentioning

confidence: 99%

Coronary flow velocity reserve predicts survival in non-diabetic patients

et al. 2012

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“…LA left atrium, RV right ventricle pathological increase in intracavitary pressures and wall stress may cause further impairment of myocardial perfusion at the subendocardial level [12,82,83]. Microvascular dysfunction is the most important substrate for recurrent ischemia in HCM, and has been shown to represent an important predictor of long-term prognosis and adverse LV remodeling [12,15,21,58,68,89].…”

Section: Microvascular Dysfunctionmentioning

confidence: 99%

The Many Faces of Hypertrophic Cardiomyopathy: From Developmental Biology to Clinical Practice

Olivotto

Girolami

Nistri

et al. 2009

J. of Cardiovasc. Trans. Res.

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Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, characterized by complex pathophysiology, heterogeneous morphology, and variable clinical manifestations over time. Besides cardiac hypertrophy, the HCM phenotype is characterized by a host of manifestations, including mitral valve and subvalvar abnormalities, subaortic and mid-ventricular left ventricular (LV) obstruction, microvascular dysfunction, myocardial fibrosis, disarray, atrial remodeling, myocardial bridging of epicardial coronary arteries, LV apical aneurysms, and autonomic nervous system abnormalities. Such heterogeneous phenotype still lacks a comprehensive explanation, which cannot be accounted solely by genetic heterogeneity, despite the large number of genes and mutations involved. It is likely that pre-natal and acquired features deriving from the primary genetic defect interact with the environment to produce the final result evident in each patient. Based on novel insights provided by cardiac developmental biology, a common lineage ancestry of several HCM manifestations might be traced back to the pluripotent epicardium-derived cells, which early during heart development differentiate into interstitial fibroblasts, coronary smooth muscle cells, and atrio-ventricular endocardial cushions as mesenchymal cells. To date, the different faces of HCM have not been sufficiently liked or explained. We here attempt to address these issues by describing the various components of the disease, their origin, interaction, and clinical significance.

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Prognostic Implications of Coronary Flow Reserve on Left Anterior Descending Coronary Artery in Hypertrophic Cardiomyopathy

Cited by 74 publications

References 30 publications

Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance

Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance

Coronary flow velocity reserve predicts survival in non-diabetic patients

The Many Faces of Hypertrophic Cardiomyopathy: From Developmental Biology to Clinical Practice

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