Prognostic implications of antibodies to Ro/SSA and soluble liver antigen in type 1 autoimmune hepatitis

Montano‐Loza, Aldo J.; Shums, Zakera; Norman, Gary L.; Czaja, Albert J.

doi:10.1111/j.1478-3231.2011.02502.x

Cited by 78 publications

(70 citation statements)

References 35 publications

(65 reference statements)

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“…25 No 2: 227-234 thyroid and are T cell-mediated organ-specific autoimmune disorders. The prevalence of AITDs is estimated to be 2-5% [13,26,27], while the prevalence of antithyroid antibodies such as TPOAb, TGAb and ATMA may be even higher [28]. The AITDs comprise two main clinical presentations: Graves' disease (GD) and HT, with clinical hallmarks of thyrotoxicosis and hypothyroidism, respectively.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Shen

Wang

Xie

et al. 2016

JGLD

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Background & Aims: The involvement of thyroid autoimmunity and dysfunction in patients with chronichepatitis C virus (HCV) infection before interferon-α (IFN-α) therapy remains controversial. We performedthis meta-analysis to evaluate the association of HCV infection with the presence of anti-thyroid antibodiesand dysthyroidism. Methods: A literature search was carried out to collect articles dated up to August 2015 to identify observationalstudies which compared the prevalence of anti-thyroid antibodies and thyroid dysfunction in IFN-α naïvechronic HCV-infected subjects with non-HCV infected controls. Random-effect or fixed-effect meta-analyseswere applied and results reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Twelve studies were included, involving 1,735 HCV-infected and 1,868 non-HCV infected subjects.Pooled anti-thyroid antibody prevalence tended to be higher in HCV-infected subjects. The prevalence ofanti-thyroglobulin antibody (TGAb), anti-thyroid peroxidase antibody (TPOAb), anti-thyroid microsomalantibody (ATMA) were 2.40-fold, 1.96-fold and 1.86-fold higher in HCV-infected subjects than in controls,respectively. The prevalence of hypothyroidism also differed by HCV infection status, with a pooled risk of3.10 (95%CI: 2.19-4.40) in HCV-infected subjects. However, the results did not show a significant differencein the prevalence of hyperthyroidism between the two groups.Conclusion: Chronic HCV infection may be an independent risk factor for thyroid disturbance. It is advisablefor the clinicians to monitor both thyroid antibodies and function in the course of chronic HCV infection,independent of IFN-α treatment. Abbreviations: AITD: autoimmune thyroid disease; ATMA: anti-thyroid microsomal antibody; CHC:chronic hepatitis; GD: Graves’ disease; HCV: hepatitis C virus; HT: Hashimoto’s thyroiditis; IFN-α: interferonalpha;NOS: Newcastle-Ottawa quality assessment scale; T3: triiodothyronine; T4: thyroxine; TGAb: antithyroglobulinantibody; TPOAb: anti-thyroid peroxidase antibody.

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Section: Discussionmentioning

confidence: 99%

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Shen

Wang

Xie

et al. 2016

JGLD

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“…15,16 Moreover, anti-SLA are associated with HLA DRB1*03 and antibodies to ribonucleoprotein/Sjogren's syndrome A antigen (anti-Ro/SSA). [17][18][19] The major limitations of the serological markers as predictive indices are that they are not pathogenic and they are variably expressed.…”

Section: Treatment Failure In Autoimmune Hepatitismentioning

confidence: 99%

Systematic review: managing suboptimal treatment responses in autoimmune hepatitis with conventional and nonstandard drugs

Selvarajah

Montano‐Loza

Czaja

2012

Aliment Pharmacol Ther

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“…The presence of anti-chromatin antibodies was correlated to more frequent relapses [43] , and anti-Ro52 to adverse outcomes and poor prognosis [44] . A large multicenter Japanese study reported that patients with AIH positive for anti-programmed cell death-1 antibody also show a delayed response to immunosuppressive therapy [45] .…”

Section: Ancillary Autoantibodiesmentioning

confidence: 99%

Autoantibodies in Autoimmune Hepatitis

Muratori

Deleonardi²,

Lalanne

et al. 2015

Dig Dis

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Background: The detection of diagnostic autoantibodies such as antinuclear antibodies (ANA), anti-smooth muscle antibodies (SMA), anti-liver/kidney microsomal type 1 (anti-LKM1), anti-liver cytosol type 1 (anti-LC1) and anti-soluble liver antigen (anti-SLA) is historically associated with the diagnosis of autoimmune hepatitis. Key Messages: When autoimmune hepatitis is suspected, the detection of one or any combination of diagnostic autoantibodies, by indirect immunofluorescence or immuno-enzymatic techniques with recombinant antigens, is a pivotal step to reach a diagnostic score of probable or definite autoimmune hepatitis. Conclusions: Diagnostic autoantibodies (ANA, SMA, anti-LKM1, anti-LC1, anti-SLA) are a cornerstone in the diagnosis of autoimmune hepatitis. Other ancillary autoantibodies, associated with peculiar clinical correlations, appear to be assay-dependent and institution-specific, and validation studies are needed.

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Prognostic implications of antibodies to Ro/SSA and soluble liver antigen in type 1 autoimmune hepatitis

Cited by 78 publications

References 35 publications

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Systematic review: managing suboptimal treatment responses in autoimmune hepatitis with conventional and nonstandard drugs

Autoantibodies in Autoimmune Hepatitis

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