Prognostic implications of anatomic location of primary cutaneous melanoma of 1 mm or thicker

Callender, Glenda G.; Egger, Michael E.; Burton, Alison; Scoggins, Charles R.; Ross, Merrick I.; Stromberg, Arnold J.; Hagendoorn, Lee; Martin, Charles G.; McMasters, Kelly M.

doi:10.1016/j.amjsurg.2011.06.048

Cited by 81 publications

(65 citation statements)

References 11 publications

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“…Head and neck melanomas have an aggressive behaviour, leading to poorer prognosis than trunk and limbs ones [30,31]. That is already evident 1 year after diagnosis, and increases at 5 years (OS5y 74% vs 89% and 90%) (Figure 10).…”

Section: Analysis Of Survivalmentioning

confidence: 83%

Survival and Prognostic Factors in Patients with Malignant Melanoma: Statistical Analysis of 466 Cases Treated between 1998 and 2014

Castellania¹,

Gm²,

Stingenib³

et al. 2017

Arch Surg Oncol

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The aim of this study is to analyse how patient's or melanoma's characteristics influence the prognosis. Therefore, we retrospectively reviewed and analysed our database, selecting 466 patients with most complete data. At diagnosis, average age is 55 years; most melanomas are in stage Ib, mean thickness amounts to 2.14 mm, with gradual reduction over the time. Ulceration is detected in 24% of cases, being associated with augmented thickness and reduced survival. Mostly, the number of mitosis per mm 2 is >1 and nodal infiltration is present in mild form. Women have more frequently primitive melanomas of the limbs; men often develop primitives on the trunk. In the head and neck district we find the highest percentages of advanced nodular melanomas. The sentinel node is positive in about 20% of cases. Elderly patients, despite lower lymphatic involvement rates, show worst prognosis. Univariate estimates on the likelihood to have positive SNs linked to individual prognostic factors demonstrate the importance of high thickness, nodular type, advanced age, presence of ulceration and absence of regression. Mean number of excised nodes during CLND is around 17. At deadline, mortality is 13.48%, overall survival at 1, 3 and 5 years is 99, 93 and 88% respectively. Survival improved among time (88 vs. 95% at 3 years, 83% vs. 90% at 5 years). Analysis of survival indicates advanced stage at diagnosis, high thickness, nodular type, head and neck location, male sex and advanced age as negative prognostic factors. The presence and quality of nodal involvement strongly affects survival: Positive nodal biopsy patients show 30% lower OS5y values, mostly in case of macroscopic tumor burden.

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Section: Analysis Of Survivalmentioning

confidence: 83%

Survival and Prognostic Factors in Patients with Malignant Melanoma: Statistical Analysis of 466 Cases Treated between 1998 and 2014

Castellania¹,

Gm²,

Stingenib³

et al. 2017

Arch Surg Oncol

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“…Crocetti e arkadaşlar n n çal şmas nda baş boyun bölgesi e diğerlerini bir grup olarak değerlendirmişler e baş boyun bölgesine lokalize olanlarda sağkal m n daha k sa olduğunu saptam şlard r (19). Callender e arkadaşlar n n çal şmas nda en k sa sağkal m baş boyun bölgesine lokalize olanlarda saptan rken en uzun sağkal m extremite bölgesinde saptanm şt r (20). u çal şmada da literatüre benzer olarak baş boyun bölgesine lokalize olanlar daha k sa sağkal m ile bağlant l saptanm ş fakat istatistiksel anlaml l ğa ulaşmam şt r.…”

Section: Discussionunclassified

Clinicopathological Analysis of Patients with Malign Melanoma

Aydın¹,

Ünal²,

Somali³

et al. 2015

Acta Oncol Tur.

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1 okuz ylül Üni ersitesi T p akültesi ç Hastal klar Ana ilim al , zmir, Türkiye. 2 zmir ozyaka ğitim Ve Araşt rma Hastanesi T bbi Onkoloji ölümü, zmir, Türkiye. 3 okuz ylül Üni ersitesi T p akültesi ç Hastal klar Ana ilim al ,t bbi Onkoloji ilim al , zmir, Türkiye. 4 zmir Üni ersitesi T p akültesi ç Hastal klar Ana ilim al ,t bbi Onkoloji ilim al , zmir, Türkiye. ÖZET GİRİŞ ve AMAÇ: u çal şmada Malign Melanom tan l hastalar n Klinikopatolojik özelliklerini incelemeyi amaçlad k. YÖNTEM ve GEREÇLER: u çal şmada okuz ylül Üni ersitesi Hastanesi T bbi Onkoloji bölümünde 1991-2011 Y llar aras nda takip edilen malign melanom tan l 166 hasta retrospektif olarak değerlendirilmiştir. BULGULAR: Hastalardan 87'si erkek, 79'u kad nd r. Tüm hastalar n ortanca yaş 52 (21-81) dir. n s k extremite bölgesinde malign melanom görülürken daha az s kl kta baş boyun e gö dede gözlenmiştir. Primer tümör bölgesi ile breslow kal nl ğ aras nda istatistiksel bir anlaml l k saptanmam şt r(p=0.109). Ancak breslow kal nl ğ ile sağ kal m aras nda istatistiksel bir fark bulunmuştur. reslow kal nl ğ 0-2 mm aras nda olanlar n ortalama sağkal m 125,6 ay(99-151), 2-4 mm aras nda olanlar n ortalama sağkal m 121,2 ay(92-151), 4 mm ve üstünde olanlar n ortalama sağkal m 89 ay(68-111) olarak saptanm şt r e aradaki fark istatistiksel olarak anlaml saptanm şt r(p=0,012). Tüm hastalar n 1 y ll k sağkal m oran %96, iki y ll k sağkal m oran %92.1 e 5 y ll k sağkal m oran %82.7 saptan rken; ortalama sağkal m süresi 89,74±6,9 ay olarak saptanm şt r. Kad n cinsiyette ortalama sağkal m 108.8 ay, erkeklerde ortalama sağkal m 72.7 ay saptanm ş olup aradaki fark istatistiksel olarak anlaml bulunmuştur(P=0,001). Melanomun primer yerleşim yerine göre sağkal mlar s ras yla baş-boyun yerleşiminde 69.6 ay, gö de 114.1 ay, extremite yerleşiminde 82.0 ay olup aradaki fark istatistiksel olarak anlaml saptanmam şt r(P=0,32). TARTIŞMA ve SONUÇ: Malign melanom en kötü seyirli deri tümörü olup prognozu etkileyen faktörler birden fazlad r. u çal şmada en önemli prognostik faktörler breslow kal nl ğ , primer tümör yerleşim bölgesi e cinsiyet olarak saptanm şt r. Anahtar Kelimeler: Malign melanoma, prognoz. ABSTRACT INTRODUCTION:Our aim in this study is to analyse patients with malign melanoma clinicopathologically. METHODS: In this study, 166 malign melanoma patients that followed by Dokuz Eylul University Hospital Medical Oncology Clinic in years between 1996 and 2011 were evaluated retrospectively. RESULTS: 87 of patients is male, 79 is female. The median age is 52 (21-81). The most common site for malign melanoma is extremity; head, neck and body are less commonly involved. There is no statistically significant difference between primary tumor site and breslow thickness (p=0.109). Breslow thickness and survival are related statistically significant. Average survival time for Breslow thickness between 0 and 2mm is 125,6 months (99-151), 2 and 4 mm is 121,2 months (92-151) and over 4mm is 89 months (68-111) and difference between groups are statistically significant (p=0,012)...

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“…Melanomun yerleşim yeri de prognozu etkiler. Ekstremitelerde yerleşen melanomun prognozunun ve yaşam süresinin, baş boyunda veya gövdede yerleşen melanomlara göre daha iyi olduğu gösterilmiştir 13 . Genetik farklılıklar da kutane melanomların yerleşimini etkileyebilmektedir.…”

Section: Discussionunclassified

The clinical and dermoscopic features of extremity melanomas

Cengiz¹,

Emiroğlu²,

Hofmann‐Wellenhof³

2015

TURKDERM

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Background and Design:Dermoscopy is a noninvasive tool that helps differentiate structures that cannot be seen by naked eye. Dermoscopic and clinical features of malignant melanomas of the extremities are not well described in the literature. Therefore, in this study, we aimed to determine the dermoscopic and clinical characteristics of melanoma of the extremities. Materials and Methods: 40 patients with melanoma of the extremities were included in this study. Their dermoscopic and clinical images, histopathological and clinical data were assessed. The relationships between Breslow thickness and dermoscopic characteristics were evaluated. Results: The most frequent localization in women was the lower extremities, whereas it was the upper extremities in men. The most common subtype of melanoma was superficial spreading melanoma of the extremities. The mean age of the males and females was 56.21±15.20 and 53.09±13.96, respectively. The most common dermoscopic feature of extremity melanoma was irregular dots (85%). Breslow thickness positively correlated with diameter of the lesion, presence of 3 or more colors in lesion, blue-white veil feature and linear white streaks (p<0. 005, r=+0.462; p<0.001, r=+0.550; p<0.001, r=+0.606; p<0.001, r=+0.662, respectively). Conclusion: To our knowledge, this is the first study investigating the dermoscopic and clinical features in patients with extremity melanomas. We suggest that melanomas of the lower extremities are more common in women than in men and patients with lower extremity melanomas

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Prognostic implications of anatomic location of primary cutaneous melanoma of 1 mm or thicker

Cited by 81 publications

References 11 publications

Survival and Prognostic Factors in Patients with Malignant Melanoma: Statistical Analysis of 466 Cases Treated between 1998 and 2014

Survival and Prognostic Factors in Patients with Malignant Melanoma: Statistical Analysis of 466 Cases Treated between 1998 and 2014

Clinicopathological Analysis of Patients with Malign Melanoma

The clinical and dermoscopic features of extremity melanomas

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