Prognostic implications of admission inflammatory profile in acute ischemic neurological events

Anuk, Turgut; Assayag, Einor Ben; Rotstein, Rivka; Fusman, Renato; Zeltser, David; Berliner, Shlomo; Avitzour, Daniel; Shapira, Itzhak; Arber, Nadir; Bornstein, Natan M.

doi:10.1034/j.1600-0404.2002.01224.x

Cited by 52 publications

(48 citation statements)

References 15 publications

(11 reference statements)

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“…A few blood test abnormalities have been identified in TIA populations in isolated studies (eg, serum viscosity, 171 prothrombin fragment 1.2 172 ), but they require further study to determine whether they affect prognosis. Similarly, inflammatory parameters such as C-reactive protein have an unclear impact on TIA prognosis because of conflicting studies, 173,174 and these tests are not routinely recommended. Impaired glucose tolerance is common in older patients with TIA or minor stroke, 175 and studies are in progress to determine whether pharmacological agents that address impaired glucose tolerance reduce stroke risk in this population.…”

Section: Routine Blood Testsmentioning

confidence: 99%

Definition and Evaluation of Transient Ischemic Attack

Easton

Saver²,

Albers³

et al. 2009

Stroke

1,557

563

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Abstract-Thishours of symptom onset, preferably with magnetic resonance imaging, including diffusion sequences; noninvasive imaging of the cervical vessels should be performed and noninvasive imaging of intracranial vessels is reasonable; electrocardiography should occur as soon as possible after TIA and prolonged cardiac monitoring and echocardiography are reasonable in patients in whom the vascular etiology is not yet identified; routine blood tests are reasonable; and it is reasonable to hospitalize patients with TIA if they present within 72 hours and have an ABCD 2 score Ն3, indicating high risk of early recurrence, or the evaluation cannot be rapidly completed on an outpatient basis. Key Words: AHA Scientific Statements Ⅲ brain Ⅲ brain ischemia Ⅲ cerebral ischemia Ⅲ ischemia Ⅲ stroke Ⅲ transient ischemic attack Ⅲ acute stroke syndromes Ⅲ acute cerebrovascular syndromes R ecent scientific studies have revised our understanding of 3 key aspects of transient ischemic attack (TIA): how it is best defined, what the early risk of stroke and other vascular outcomes is, and how it is best evaluated. This statement reviews and synthesizes recent scientific advances regarding the definition, urgency, and evaluation of TIA and is designed to aid the clinician in the short-and long-term management of patients with TIA. DefinitionTIAs are brief episodes of neurological dysfunction resulting from focal cerebral ischemia not associated withThe American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee on January 16, 2009. A copy of the statement is available at http://www.americanheart.org/presenter.jhtml?identifierϭ3003999 by selecting either the "topic list" link or the "chronological list" link (No. LS-2037). To purchase additional reprints, call 843-216-2533 or e-mail kelle.ramsay@wolterskluwer.com.Expert peer review of AHA Scientific Statements is conducted at the AHA National Center. For more on AHA statements and guidelines development, visit http://www.americanheart.org/presenter.jhtml?identifierϭ3023366.Permissions: Multiple copies, modification, alteration, enhancement, and/or distribution of this document are not permitted without the express permission of the American Heart Association. Instructions for obtaining permission are located at http://www.americanheart.org/presenter.jhtml?identifierϭ4431. A link to the "Permission Request Form" appears on the right side of the page.© 2009 American Heart Association, Inc. UrgencyLarge cohort and population-based studies reported in the last 5 years have demonstrated a higher risk ...

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Section: Routine Blood Testsmentioning

confidence: 99%

Definition and Evaluation of Transient Ischemic Attack

Easton

Saver²,

Albers³

et al. 2009

Stroke

1,557

563

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show abstract

“…15,82 Moreover, some reports have reported a positive association between CRP values and stroke severity or neurological disability. 12,15,[17][18][19]80,82 Although single measures of CRP taken within 72 hours of stroke onset are of prognostic value in selected populations, the value of this in patients with concurrent infection or other inflammatory comorbidities has not been established and the optimal timing and number of repeat samples also not determined. In the presence of overt inflammatory disease or infection, data should be interpreted cautiously and possibly CRP titration repeated after the underlying acute insult has resolved for long-term stratification purposes.…”

Section: Secondary Prevention Of Stroke: What Is the Role Of Crp As Amentioning

confidence: 99%

“…The predictive accuracy of isolated CRP measurement is limited regarding traditional risk factors. 171 An elevated CRP in this setting is associated with increased mid-term to long-term risk, 11,[13][14][15][17][18][19]79,80,82 and thus additional evaluation modalities may be warranted.…”

Section: Is the Measurement Of Plasma Crp Justified In The Routine CLmentioning

confidence: 99%

“…C-reactive protein (CRP), a peripheral marker of inflammation, has consistently been observed to be related to the risk of cerebrovascular and cardiovascular (CV) events [1][2][3][4][5][6][7][8][9][10] and is consistently elevated in the circulation of patients after acute ischemic stroke, [11][12][13][14][15][16][17][18][19][20] even when factors known to be associated with raised CRP concentrations such as infection and atherosclerosis are taken into account. 20 These important clinical data are also supported by abundant laboratory and experimental evidence demonstrating that atherothrombosis represents a chronic inflammatory process.…”

mentioning

confidence: 99%

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Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke

Napoli

Schwaninger

Cappelli

et al. 2005

Stroke

261

197

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Background and Purpose-Several studies have shown, in different populations, that modest elevation of plasma C-reactive protein (CRP) in the range seen in apparently healthy individuals is a strong predictor of future vascular events. Elevated plasma CRP concentrations are also associated with an increased risk of cerebrovascular events and an increased risk of fatal and nonfatal cardiovascular events in ischemic stroke patients. These epidemiological and clinical observations suggest that determination of plasma CRP concentrations could be used as an adjunct for risk assessment in primary and secondary prevention of cerebrovascular disease and be of prognostic value. The aim of this review is to summarize the evidence for CRP as an independent predictor of cerebrovascular events in at-risk individuals and ischemic stroke patients and to consider its usefulness in evaluating prognosis after stroke. Summary of Review-CRP fulfils most of the requirements of a new risk and prognostic predictor, but several issues await further confirmation and clarification before this marker can be included in the routine evaluation of stroke patients and subjects at risk for cerebrovascular disease. Potentially important associations have been established between elevated plasma CRP concentrations and increased efficacy of established therapies, particularly lipid-lowering therapy with statins. Conclusion-At present, there is not sufficient evidence to recommend measurement of CRP in the routine evaluation of cerebrovascular disease risk in primary prevention, because there is insufficient evidence as to whether early detection, or intervention based on detection, improves health outcomes, although shared risk of cardiovascular disease indicates this may be of value. In secondary prevention of stroke, elevated CRP adds to existing prognostic markers, but it remains to be established whether specific therapeutic options can be derived from this.

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“…İnmeli hastalarda prognozun altta yatan atesklerotik damar hastalığı ile ilişkili olduğu belirtilmektedir (8,9). İnmelerin çoğu iskemik kaynaklı olup; karotis aterosklerozu iskemik inmelerin yaklaşık %20'sinden sorumludur.…”

Section: Introductionunclassified

Determination of the level of knowledge of stroke among patients aged 60 years and older

Üçer¹,

Keten²,

Kuş³

et al. 2017

Eur J Ther

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ÖZGiriş: Bu çalışmada 60 yaş ve üzeri bireylerin inme konusunda bilgi düzeylerinin belirlenmesi amaçlanmaktadır. Materyal ve Metod:Bu çalışmaya 01.03.2015-13.06.2015 tarihleri arasında Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Hastanesi polikliniklerine herhangi bir sebeple başvuran 60 yaş ve üzeri 172 birey dahil edildi. Ankette katılımcıların inme risk faktör-lerine yönelik bilgi durumu 11 soru, inme belirtilerine yönelik bilgi durumu 10 soru ile sorgulandı. Bulgular: Çalışmamızda yer alan katılımcıların yaş ortalaması 68.05 ± 7.04 (min= 60, maks= 88) olarak saptandı. Daha önce "inme" terimini katılımcıların 83 (%48.3)'ü duyduğunu, 89 (%51.7)'u ise duymadığını belirtti. Bireylerin inme risk faktörleri bilgi puanı 7.18 ± 3.21, inme belirtileri bilgi puanı 7.12 ± 2.81 olarak tespit edildi. İnme risk faktörleri bilgi puanı kadınlarda 7.09 ± 3.18, erkeklerde 7.26 ± 3.26 olarak saptandı. İnme belirtileri bilgi puanı kadınlarda 7.42 ± 2.76, erkeklerde 6.88 ± 2.84 olarak belirlendi. Erkek ve kadınların inme risk faktörü bilgi puanı (p= 0.737) ve inme belirtileri bilgi puanı (p= 0.213) benzer olarak saptandı.Sonuç: Çalışmamızda 60 yaş ve üzeri bireylerin inme konusunda ciddi bilgi eksiklikleri olduğu saptandı. Özellikle inme için yaş gibi önemli bir risk faktörünü taşıyan bu bireylere inme konusunda eğitimlerin verilmesi koruyucu halk sağlığı politikaları için önem taşımaktadır.Anahtar Kelimeler: İnme, yaşlı, bilgi ABSTRACT Introduction: The aim of the present study is to determine the level of knowledge of stroke among subjects aged 60 years and older.

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Prognostic implications of admission inflammatory profile in acute ischemic neurological events

Abstract: Admission inflammatory markers have long-term prognostic implications in patients with acute ischemic neurological events. These findings are relevant in view of the new therapeutic interventions now available for reducing the inflammatory response.

Cited by 52 publications

References 15 publications

Definition and Evaluation of Transient Ischemic Attack

Definition and Evaluation of Transient Ischemic Attack

Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke

Determination of the level of knowledge of stroke among patients aged 60 years and older

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