Prognostic Implication of Plasma Osteopontin Levels in Patients with Chronic Kidney Disease

Abstract

Aims: To assess (a) plasma osteopontin (pOPN) in a cohort of chronic kidney disease (CKD) patients; (b) the relationship between pOPN and aortic calcification and stiffness, and (c) the association between pOPN and the overall and cardiovascular mortality risk. Methods: pOPN, the abdominal aortic calcification score and pulse wave velocity (PWV) were determined in 94 CKD patients (68 ± 13 years; 60% males; 31% at CKD stages 2–3, 31% at stages 4–5, 38% at stage 5D), prospectively followed for mortality. Results: pOPN was higher in CKD patients than in controls. Interleukin (IL)-6 (r² = 0.086; p = 0.004), CRP (r² = 0.046; p = 0.038), iPTH (r² = 0.065; p = 0.014), albumin (r² = 0.210; p < 0.0001) and statin use (r² = 0.038; p = 0.059) were associated with pOPN. There was no association between pOPN and the aortic calcification score or PWV. During follow-up (969 ± 405 days), 32 patients died. In crude analysis, pOPN >167 ng/ml predicted overall and cardiovascular mortality (p = 0.02 and 0.01, respectively), but this effect was lost after adjustment for albumin or IL-6. Conclusions: pOPN is elevated from the early stages of CKD onward. We found no associations between pOPN and the aortic calcification score or the PWV. The positive association between pOPN and clinical outcomes was dependent of the patients’ inflammatory status.

Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification

“…These increased levels also correlated closely with serum phosphate and intact parathyroid hormone. Comparable findings by Barreto et al in CKD patients and Yamaguchi et al in diabetic patients with renal failure demonstrated increased serum OPN levels that associated with loss of renal function 54, 55 . It is likely that OPN levels increase to offset further pathologic renal calcification as OPN is upregulated at sites of pathologic calcification.…”

The Impact of Osteocalcin, Osteoprotegerin and Osteopontin on Arterial Stiffness in Chronic Renal Failure Patients on Hemodialysis

“…In patients with chronic kidney disease elevated circulating OP level has been reported but except for a small group of HD patients no independent association could be detected between OP level and VC [46, 47]. In experimental uremia plasma OP was increased and correlated positively with aortic atherosclerosis [48].…”

Novel Biomarkers Assessing the Calcium Deposition in Coronary Artery Disease

“…Specifically, in hemodialysis patients, OPN levels have been found to be significantly elevated as compared with control subjects, and to be positively correlated with the degree and severity of aortic calcification [113]. Elevated plasma OPN levels were found during the early stages of chronic kidney disease (CKD) [114]. However, no association was found between OPN and aortic calcification score [114].…”

“…Elevated plasma OPN levels were found during the early stages of chronic kidney disease (CKD) [114]. However, no association was found between OPN and aortic calcification score [114]. The positive association between plasma OPN and clinical outcomes (such as overall and cardiovascular mortality) was also associated with inflammatory status [114].…”