Prognostic impacts of serum levels of C-reactive protein, albumin, and total cholesterol in patients with myelodysplastic syndromes

Yanagisawa, Hiroto; Kawabata, Hiroshi; Ueda, Yusuke; Arita, Kotaro; Iwao-Kawanami, Haruka; Sakai, Tomoyuki; Kawanami, Takafumi; Yamada, Kazunori; Mizuta, Shuichi; Fukushima, Toshihiro; Yasukawa, Masaki

doi:10.1007/s12185-022-03321-z

Cited by 1 publication

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“…Increased baseline CRP concentrations have been linked to shorter survival and the development of second cancers in cases with chronic lymphocytic leukemia, and a study found no significant differences in CRP levels between acute lymphoid and myeloid leukemia that can be useful as an indicator for disease course, and that they were was reduced after treatment, while another study in acute myeloid leukemia and myelodysplastic syndromes found that transplant-related mortality was linked to the pre-specified threshold of CRP > 10 mg/L [ 779 , 780 , 781 ]. Elevated CRP has been reported to have an independent prognostic impact in myelodysplastic syndrome subjects, whereas elevated values can indicate clonal hematopoiesis and non-hematological comorbidities in cases with low-risk myelodysplastic syndromes [ 782 , 783 ]. Moreover, some other data have linked CRP elevation with myeloproliferative disorders, and other data have revealed a possible CRP SNP association with certain myeloproliferative neoplasms (primary myelofibrosis and essential thrombocythemia) [ 784 ].…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

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Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

View full text Add to dashboard Cite

show abstract

Prognostic impacts of serum levels of C-reactive protein, albumin, and total cholesterol in patients with myelodysplastic syndromes

Cited by 1 publication

References 37 publications

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

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