Prognostic impact over time of ischaemic heart disease vs. non‐ischaemic heart disease in heart failure

Silverdal, Jonas; Sjöland, H; Bollano, Entela; Pivodic, Aldina; Dahlström, Ulf; Fu, Michael

doi:10.1002/ehf2.12568

Cited by 15 publications

(21 citation statements)

References 26 publications

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“…More specifically, our study is the first one investigating the potential synergism between HF and CAD on short-term risk of mortality among COVID-19 patients and extending previous data from general population studies of patients with HF [ 28 , 29 ]. A recent analysis of a Registry from Sweden showed that CAD is a powerful and independent predictor of death in patients with non-valvular HF [7] . Since patients were followed for a median of 2.4 years, [7] the impact of the combination between HF and CAD in the short-term remained unclear.…”

Section: Discussionmentioning

confidence: 99%

“…A recent analysis of a Registry from Sweden showed that CAD is a powerful and independent predictor of death in patients with non-valvular HF [7] . Since patients were followed for a median of 2.4 years, [7] the impact of the combination between HF and CAD in the short-term remained unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Although an interaction between these two conditions may be postulated in the general population of HF patients [7] , their joint effect on the risk of death among COVID-19 patients remains to be explicitly examined using data collected in a prospective fashion.…”

Section: Introductionmentioning

confidence: 99%

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Joint effect of heart failure and coronary artery disease on the risk of death during hospitalization for COVID-19

Angeli

Marazzato

Verdecchia³

et al. 2021

European Journal of Internal Medicine

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Aims : Heart failure (HF) and coronary artery disease (CAD) are independent predictors of death in patients with COVID-19. The adverse prognostic impact of the combination of HF and CAD in these patients is unclear. Methods and results : we analysed data from 954 consecutive patients hospitalized for SARS-CoV-2 in five Italian Hospitals from February 23 to May 22, 2020. The study was a systematic prospective data collection according to a pre-specified protocol. All-cause mortality during hospitalization was the outcome measure. Mean duration of hospitalization was 33 days. Mortality was 11% in the total population and 7.4% in the group without evidence of HF or CAD (reference group). Mortality was 11.6% in the group with CAD and without HF (odds ratio [OR]: 1.6, p=0.120), 15.5% in the group with HF and without CAD (OR: 2.3, p=0.032), and 35.6% in the group with CAD and HF (OR: 6.9, p<0.0001). The risk of mortality in patients with CAD and HF combined was consistently higher than the sum of risks related to either disorder, resulting in a significant synergistic effect (p<0.0001) of the two conditions. Age-adjusted attributable proportion due to interaction was 64%. Adjusting for the simultaneous effects of age, hypotension, and lymphocyte count did not significantly lower attributable proportion which persisted statistically significant (p=0.0360). Conclusion : The combination of HF and CAD exerts a marked detrimental impact on the risk of mortality in hospitalized patients with COVID-19, which is independent on other adverse prognostic markers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Joint effect of heart failure and coronary artery disease on the risk of death during hospitalization for COVID-19

Angeli

Marazzato

Verdecchia³

et al. 2021

European Journal of Internal Medicine

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“…21,22 In addition, IHD in patients with HF is associated with increased mortality. 23 IHD is more common in men than in women, 24 and the declining mortality in IHD during the last few decades 25,26 might therefore have a greater impact on mortality in men than in women. Another Swedish study comparing patients with HF of ischaemic and non-ischaemic aetiologies from 1987 to 2003 revealed the most marked decrease in 3 year mortality in men aged 35 to 64 years with ischaemic HF and a less marked reduction in 3 year mortality for women.…”

Section: Discussionmentioning

confidence: 99%

Increasing home‐time after a first diagnosis of heart failure in Sweden, 20 years trends

Ekestubbe

Giang

et al. 2021

ESC Heart Failure

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Aims This study was performed to compare trends in home-time for patients with heart failure (HF) between those of working age and those of retirement age in Sweden from 1992 to 2012. Methods and resultsThe National Inpatient Register (IPR) was used to identify all patients aged 18 to 84 years with a first hospitalization for HF in Sweden from 1992 to 2012. Information on date of death, comorbidities, and sociodemographic factors were collected from the Swedish National Register on Cause of Death, the IPR, and the longitudinal integration database for health insurance and labour market studies, respectively. The patients were divided into two groups according to their age: working age (<65 years) and retirement age (≥65 years). Follow-up was 4 years. In total, following exclusions, 388 775 patients aged 18 to 84 years who were alive 1 day after discharge from a first hospitalization for HF were included in the study. The working age group comprised 62 428 (16%) patients with a median age of 58 (interquartile range, 53-62) years and 31.2% women, and the retirement age group comprised 326 347 (84%) patients with a median age of 77 (interquartile range, 73-81) years and 47.4% women. Patients of working age had more home-time than patients of retirement age (83.8% vs. 68.2%, respectively), mainly because of their lower 4 year mortality rate (14.2% vs. 29.7%, respectively). Home-time increased over the study period for both age groups, but the increase levelled off for older women after 2007, most likely because of less reduction in mortality in older women than in the other groups. Conclusions This nationwide study showed increasing home-time over the study period except for women of retirement age and older for whom the increase stalled after 2007, mainly because of a lower mortality reduction in this group. Efforts to improve patient-related outcome measures specifically targeted to this group may be warranted.

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“…In addition, HF itself may increase the incidence of diabetes. 10 To date, the prognostic importance of ischaemic aetiology in HFrEF has been studied with conflicting conclusions, 2,5,6,[11][12][13] but concomitant coronary artery disease per se appeared not to increase risk in DCM over a mean follow-up 36.3 months. 14 The association between common co-morbidities and outcome in patients with DCM is inadequately studied, and to what extent HF duration affects the prognosis in a contemporary DCM cohort remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Prognostic differences in long‐standing vs. recent‐onset dilated cardiomyopathy

et al. 2022

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AimsThis study aimed to evaluate the outcome and prognostic factors in patients with dilated cardiomyopathy (DCM) and long-standing heart failure (LDCM) vs. recent-onset heart failure (RODCM). Methods and resultsWe compared 2019 patients with RODCM (duration <6 months, mean age 58.6 years, 70.7% male) with 1714 patients with LDCM (duration ≥6 months, median duration 3.5 years, mean age 62.5 years, 73.7% male) included in the Swedish Heart Failure Registry in the years 2003-16. Outcome measures were all-cause, cardiovascular (CV), and non-CV death and hospitalizations; heart transplantation; and a combined outcome of all-cause death, heart transplantation, or heart failure (HF) hospitalization. Multivariable risk factor analyses were performed for the combined endpoint. All outcomes were more frequent in LDCM than in RODCM. The multivariable-adjusted hazard ratios (HRs) (95% confidence interval) for LDCM vs. RODCM were 1.56 (1.34-1.82), P < 0.0001, for all-cause death over a median follow-up of 4.2 and 5.0 years, respectively; 1.67 (1.36-2.05), P < 0.0001, for CV death; 2.12 (1.14-3.91), P < 0.0001, for heart transplantation; 1.36 (1.21-1.53), P < 0.0001, for HF hospitalization; and 1.37 (1.24-1.52), P < 0.0001, for the combined outcome. A propensity score-matched analysis yielded similar results. CV death was the main cause of mortality in LDCM and was higher in LDCM than in RODCM (P < 0.0001). Almost all co-morbidities were significantly more frequent in LDCM than in RODCM, and the mean number of co-morbidities increased significantly with increased duration of disease, also after age adjustment. Age, New York Heart Association functional class, ejection fraction, and left bundle branch block were prognostically adverse. The only co-morbidity associated with the combined outcome regardless of HF duration was diabetes, in LDCM [

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Prognostic impact over time of ischaemic heart disease vs. non‐ischaemic heart disease in heart failure

Cited by 15 publications

References 26 publications

Joint effect of heart failure and coronary artery disease on the risk of death during hospitalization for COVID-19

Joint effect of heart failure and coronary artery disease on the risk of death during hospitalization for COVID-19

Increasing home‐time after a first diagnosis of heart failure in Sweden, 20 years trends

Prognostic differences in long‐standing vs. recent‐onset dilated cardiomyopathy

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