Prognostic impact of vascular invasion in differentiated thyroid carcinoma: a systematic review and meta-analysis

Abstract

Our study demonstrated a significant impact of VI on tumor recurrence and patient survival in DTC patients. The presence and extent of VI should be considered an adverse prognostic factor in DTCs.

Prognostic importance of solid variant papillary thyroid carcinoma: A systematic review and meta‐analysis

“…Our meta‐analysis results demonstrated that most of the clinicopathological behaviors of SVPTC are not statistically different from those of cPTC. However, this PTC variant was associated with an elevated risk for vascular invasion, which has recently been confirmed as a risk factor for tumor recurrence and patient mortality in differentiated thyroid carcinoma . As a consequence, SVPTC was found to have worse disease‐free survival in comparison to cPTC in our study.…”

“…However, this PTC variant was associated with an elevated risk for vascular invasion, which has recently been confirmed as a risk factor for tumor recurrence and patient mortality in differentiated thyroid carcinoma. 36 As a consequence, SVPTC was found to have worse disease-free survival in comparison to cPTC in our study. Although the presence of vascular invasion in thyroid cancer is strongly associated with distant metastasis, we did not find a significantly increased risk for distant metastasis in SVPTC, most likely due to the small number of cases included in the analysis.…”

“…Further meta‐analysis studies with appropriate search term, study design, and approaches for data extraction and analyses should be conducted to solve these ongoing debates. In a recent meta‐analysis on prognostic importance of vascular invasion, we demonstrated that the presence of vascular invasion in PTC is associated with a significantly increased risk for both local and distance recurrence …”

The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives

“…In the 2015 AFIP atlas, FTC was classified into four prognostic groups: (i) minimally invasive FTC with capsular invasion; (ii) minimally invasive FTC with limited (<4 vessels) vascular invasion; (iii) minimally invasive FTC with extensive (≥4 vessels) vascular invasion; and (iv) widely invasive FTC . These two classifications highlighted the importance of vascular invasion in risk stratification of thyroid carcinomas . As FT‐UMP and WDT‐UMP were introduced in the thyroid tumor classification, evaluation of capsular and vascular invasion has become much stricter, and only definite invasion (Fig.…”

“…156 These two classifications highlighted the importance of vascular invasion in risk stratification of thyroid carcinomas. [157][158][159][160][161][162][163][164][165] As FT-UMP and WDT-UMP were introduced in the thyroid tumor classification, 1,32,33 evaluation of capsular and vascular invasion has become much stricter, and only definite invasion (Fig. 5a, b) is accepted for the diagnosis of FTC.…”