Prognostic impact of tumor volumetry in patients with locally advanced head-and-neck carcinoma (non-nasopharyngeal) treated by radiotherapy alone or combined radiochemotherapy in a randomized trial

Plataniotis, George A.; Theofanopoulou, M.A.; Kalogera‐Fountzila, Anna; Haritanti, Afroditi; Ciuleanou, Elisabeta; Ghilezan, N.; Zamboglou, Nikolaos; Dimitriadis, Athanasios; Sofroniadis, Ioannis; Fountzilas, George

doi:10.1016/j.ijrobp.2004.01.021

Cited by 64 publications

(62 citation statements)

References 24 publications

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“…In recent studies, MNV and primary tumor volume were reported to play important roles in predicting prognosis [8,9,20,21]. In an analysis of 79 HNSCC patients who underwent primary irradiation or chemoradiation, MNV was the most important prognostic factor for the control of pathological nodes in the neck [20].…”

Section: Discussionmentioning

confidence: 99%

“…In an analysis of 79 HNSCC patients who underwent primary irradiation or chemoradiation, MNV was the most important prognostic factor for the control of pathological nodes in the neck [20]. Another study on 94 HNSCC patients showed that not only the total tumor volume (primary tumor volume plus MNV) but also the MNV were significant prognostic factors for OS [21]. Furthermore, these prior studies may suggest that the MNV plays an important role in predicting prognosis in CUP patients who have no primary tumor burden.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Value of Metastatic Nodal Volume and Lymph Node Ratio in Patients with Cervical Lymph Node Metastases from an Unknown Primary Tumor

Park

Jung²,

Roh³

et al. 2014

Oncology

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Objective: The presence of metastatic cervical lymph nodes (MCNs) is an unfavorable prognostic factor in head and neck cancer. The total volume of MCNs (MNV) and the lymph node ratio (LNR) may be superior to conventional nodal staging in cervical metastasis from an unknown primary tumor (CUP). We evaluated the prognostic value of MNV and LNR in CUP patients. Methods: Thirty-nine patients with CUP who underwent surgery plus postoperative radiotherapy were reviewed. MNV was measured by preoperative computed tomography and LNR was determined using neck dissection samples. The association of clinicopathologic factors, MNV, and LNR with disease-free survival (DFS) and overall survival (OS) was analyzed. Results: Five-year DFS and OS were 68.4 and 70.8%, respectively, for a median follow-up of 49 months. In multivariate analysis, MNV (>30 ml) was an independent prognostic factor for both DFS and OS (p = 0.004 and p < 0.001, respectively). LNR (>0.14) was identified as an independent predictive factor for DFS (p = 0.041). Conclusion: MNV and LNR are independent prognostic factors in patients with CUP and could facilitate the identification of high-risk patients requiring intensive treatment and surveillance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Metastatic Nodal Volume and Lymph Node Ratio in Patients with Cervical Lymph Node Metastases from an Unknown Primary Tumor

Park

Jung²,

Roh³

et al. 2014

Oncology

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“…In view of the established predictive value of metastatic disease (lymph nodal and distant), we looked at the influence of stage at presentation on patient outcome but did not find any significant correlation. Although a larger tumor size at presentation has a negative influence on patient outcome (30), there is evidence that the extent of hypoxia does not correlate with tumor size (19,29). Our multivariate analysis took into account the tumor and node status as well as T stage in evaluating the influence of FMISO-PET.…”

Section: Discussionmentioning

confidence: 99%

Tumor Hypoxia Imaging with [F-18] Fluoromisonidazole Positron Emission Tomography in Head and Neck Cancer

Rajendran

Schwartz

O’Sullivan

et al. 2006

Clinical Cancer Research

320

238

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Purpose: Advanced head and neck cancer shows hypoxia that results in biological changes to make the tumor cells more aggressive and less responsive to treatment resulting in poor survival. [F-18] fluoromisonidazole (FMISO) positron emission tomography (PET) has the ability to noninvasively quantify regional hypoxia. We investigated the prognostic effect of pretherapy FMISO-PETon survival in head and neck cancer. Experimental Design: Seventy-three patients with head and neck cancer had pretherapy FMISO-PETand 53 also had fluorodeoxyglucose (FDG) PETunder a research protocol from April 1994 to April 2004. Results: Significant hypoxia was identified in 58 patients (79%). The mean FMISO tumor/ blood max (T/B max ) was 1.6 and the mean hypoxic volume (HV) was 40.2 mL. There were 28 deaths in the follow-up period. Mean FDG standard uptake value (SUV) max was 10.8.The median time for follow-up was 72 weeks. In a univariate analysis,T/B max (P = 0.002), HV (P = 0.04), and the presence of nodes (P = 0.01) were strong independent predictors. In a multivariate analysis, including FDG SUV max , no variable was predictive at P < 0.05. When FDG SUV max was removed from the model (resulting in n = 73 with 28 events), nodal status and T/B max (or HV) were both highly predictive (P = 0.02, 0.006 for node andT/B max , respectively; P = 0.02 and 0.001for node and HV, respectively).Conclusions: Pretherapy FMISO uptake shows a strong trend to be an independent prognostic measure in head and neck cancer.

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“…Therefore, we can expect that tumor burden, a threedimensional volumetric measurement, may be more reliable for the assessment of tumor extent, and serve as a better independent prognostic factor than pT stage [14]. Plataniotis et al [29] found that GTV correlated with treatment outcomes for patients with locally advanced HNSCC treated with radiation therapy or radiation therapy plus chemo therapy. Several authors also reported that GTV obtained from CT scan was a significant predictor for clinical outcome in the treatment of HNSCC [10,[30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Choi

Yoo

Han

et al. 2010

Nucl Med Mol Imaging

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Purpose We assessed the prognostic value of metabolic tumor volume (MTV) measured using 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) inpatients with locally advanced head and neck squamous cell carcinoma (HNSCC). Methods We retrospectively reviewed 56 patients (51 men, five women; mean age 56.0±8.8years) who had locally advanced HNSCC and underwent FDG PET/CT for initial evaluation. All patients had surgical resection and radiotherapy with or without concurrent chemotherapy. The peak standardized uptake value (SUV peak ) and MTV of the target lesion, including primary HNSCC andmetastatic cervical lymph nodes, were measured from FDG PET/CT images. We compared SUV peak , MTV, and clinicopathologic variables such as age, Eastern Cooperative Oncology Group (ECOG) performance status, pN stage, pT stage, TNM stage, histologic grade and treatment modality to disease-free survival (DFS) and overall survival (OS). Results On the initial FDG PET/CT scans, the median SUV peak was 7.8 (range, 1.8-19.0) and MTV was17.0 cm 3 (range, 0.1-131.0 cm 3 ). The estimated 2-year DFS and OS rates were 67.2% and 81.8%. The cutoff points of SUV peak 6.2 and MTV 20.7 cm 3 were the best discriminative values for predicting clinical outcome. MTV and ECOG performance status were significantly related to DFS and OS on univariate and multivariate analyses (p<0.05). Conclusion The MTV obtained from initial FDG PET/CT scan is a significant prognostic factor for disease recurrence and mortality in locally advanced HNSCC treated with surgery and radiotherapy with or without chemotherapy.

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Prognostic impact of tumor volumetry in patients with locally advanced head-and-neck carcinoma (non-nasopharyngeal) treated by radiotherapy alone or combined radiochemotherapy in a randomized trial

Cited by 64 publications

References 24 publications

Prognostic Value of Metastatic Nodal Volume and Lymph Node Ratio in Patients with Cervical Lymph Node Metastases from an Unknown Primary Tumor

Prognostic Value of Metastatic Nodal Volume and Lymph Node Ratio in Patients with Cervical Lymph Node Metastases from an Unknown Primary Tumor

Tumor Hypoxia Imaging with [F-18] Fluoromisonidazole Positron Emission Tomography in Head and Neck Cancer

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

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