Prognostic impact of transcription factor Fra-1 in ER-positive breast cancer: contribution to a metastatic phenotype through modulation of tumor cell adhesive properties

Oliveira‐Ferrer, Leticia; Kürschner, Melanie; Labitzky, Vera; Wicklein, Daniel; Müller, Volkmar; Lüers, Georg H.; Schumacher, Udo; Milde‐Langosch, Karin; Schröder, Christine

doi:10.1007/s00432-015-1925-2

Cited by 15 publications

(11 citation statements)

References 47 publications

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“…High levels of Fra-1 in cells where elevated ERK activity leads to protein stabilization provide survival signals for tumor cells removed from the extracellular matrix (31). Fra-1 may influence the metastatic potential of breast cancer cells by altering the expression of adhesion molecules, resulting in increased adherence to endothelial cells under flow conditions (32). Collectively, the results suggested that Fra-1 may affect cell proliferation, invasion and apoptosis.…”

Section: Discussionmentioning

confidence: 94%

Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway

et al. 2015

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Fos-related antigen-1 (Fra-1) is a member of the activator protein-1 transcription factor superfamily. It plays important roles in oncogenesis in various types of malignancies. Herein, we investigated the expression of Fra-1 in lung cancer tissues by qPCR, immunohistochemistry, and western blot technologies. The results showed that Fra-1 was overexpressed in the lung cancer tissues when compared with the level in the adjacent non-cancerous tissues. To explore the possible mechanism of Fra-1 in lung cancer, we elucidated the effect of Fra-1 on the apoptosis of lung cancer H460 cells, and found that the rate of cell apoptosis was decreased in the H460/Fra-1 cells compared with the H460 or H460/vector cells. Cell apoptosis is closely related with a reduction in mitochondrial membrane potential (ΔΨm) and an increase in intracellular reactive oxygen species (ROS) and calcium ion (Ca2+) concentrations. Our results showed that overexpression of Fra-1 in the lung cancer H460 cells, led to an increase in ΔΨm and and a decrease in intracellular ROS and Ca2+ concentrations. Furthermore, we found that Fra-1 was correlated with dysregulation of the P53 signaling pathway in lung cancer tissues in vitro. At the same time, we found that Fra-1 overexpression affected the expression of MDM2 and P53 in vivo. In summary, our results suggest that Fra-1 is upregulated in lung cancer tissues and functions by affecting the P53 signaling pathway in lung cancer.

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Section: Discussionmentioning

confidence: 94%

Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway

et al. 2015

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“…High AP-1 expression is associated with poor prognosis of breast cancer. For example, analysis of cDNA microarray data including 197 breast cancer patients showed that high expression of Fra-1 significantly correlates with shorter overall survival and higher percentage of lung metastasis in ERα-positive breast cancer patients [215]. Moreover, a role for Fra-1 or c-Jun in promoting breast cancer cell metastasis in vivo has been demonstrated in a zebrafish tumor xenograft model [214], and Fra-1 has been identified as a key regulator involved in the process of metastasis in rodent model systems [216].…”

Section: The Role Of Ap-1 In Breast Cancermentioning

confidence: 99%

Endogenous interaction profiling identifies DDX5 as an oncogenic coactivator of transcription factor Fra-1

Song

Sinha

et al. 2019

Oncogene

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“…Fra-1 is required for invasion and Fra-1 might be a good target for intervention in colorectal cancer (3,5,6). In addition to its pro-invasive and pro-migratory effect, Fra-1 might influence the metastatic potential of breast cancer cells by changing the expression of adhesion molecules, resulting in increased adherence to endothelial cells (1,7,8). Although some evidence has been reported, the mechanism of Fra-1 in malignancy is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer

Zhu

Gao

et al. 2015

International Journal of Oncology

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Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Fra-1 (FOSL1) plays important roles in oncogenesis in various malignancies. We investigated the expression of Fra-1 in gastric cancer (GC) tissues by qPCR, immunohistochemistry (IHC) and western blot technologies. The results showed that Fra-1 was overexpressed in gastric cancer tissues compared with the adjacent non‑cancerous tissues. To explore the possible mechanism of Fra-1 in GC, we elucidated the effect of Fra-1 in the apoptosis and cell cycle of gastric cancer cells, AGS, and found that a considerable decrease in apoptotic cells and increase of S phase rate were observed for AGS cells with Fra-1 overexpession. We identified and confirmed that Fra-1 affected the expression level of CTTN and EZR in vitro through LC-MS/MS analyses and western blot technology. Furthermore, we found that Fra-1 was correlated with dysregulation PI3K/Akt and p53 signaling pathway in gastric cancer tissues in vitro. Moreover, we found that Fra-1 overexpression affected the expression of PI3K, Akt, MDM2 and p53 in vivo. In summary, our results suggest that Fra-1 is upregulated in gastric cancer tissues and plays its function by affecting the PI3K/Akt and p53 signaling pathway in gastric cancer.

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Prognostic impact of transcription factor Fra-1 in ER-positive breast cancer: contribution to a metastatic phenotype through modulation of tumor cell adhesive properties

Abstract: Thus, in addition to its pro-invasive and pro-migratory effect, Fra-1 might influence the metastatic potential of breast cancer cells by changing the expression of adhesion molecules, resulting in increased adherence to endothelial cells under flow conditions.

Cited by 15 publications

References 47 publications

Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway

Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway

Endogenous interaction profiling identifies DDX5 as an oncogenic coactivator of transcription factor Fra-1

Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer

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