Prognostic impact of the controlling nutritional status score in patients with peripheral T-cell lymphoma

Nakamura, Nobuhiko; Kanemura, Nobuhiro; Lee, Shin; Fujita, Kazuo; Morishita, Tetsuji; Takada, Eri; Shibata, Yuhei; Kasahara, Senji; Goto, Hideko; Fukuno, Kenji; Hara, Takeshi; Yamada, Toshiki; Sawada, Michio; Tsurumi, Hisashi; Shimizu, Masahito

doi:10.1080/10428194.2021.2020777

Cited by 11 publications

(24 citation statements)

References 19 publications

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“…This result was similar to previous studies. A study including 99 newly diagnosed patients with PTCL presented strong evidence identifying a significant correlation between higher CONUT scores and worse clinical parameters, including B symptoms, ECOG score ≥2, and high IPI score 16 . Moreover, a recent retrospective study of 476 DLBCL cases found that a high CONUT score was correlated with older age, advanced stage, abnormal LDH levels, B symptoms, and high NCCN‐IPI score 15 .…”

Section: Discussionmentioning

confidence: 99%

“…A study including 99 newly diagnosed patients with PTCL presented strong evidence identifying a significant correlation between higher CONUT scores and worse clinical parameters, including B symptoms, ECOG score ≥2, and high IPI score. 16 Moreover, a recent retrospective study of 476 DLBCL cases found that a high CONUT score was correlated with older age, advanced stage, abnormal LDH levels, B symptoms, and high NCCN‐IPI score. 15 Based on the function of ALB, T‐CHOL, and TL, the associations between CONUT score and the basic variables of ENKTL might be clarified, as ALB, for an example, is used for the assessment of nutritional status as well as immune function.…”

Section: Discussionmentioning

confidence: 99%

“…14 Currently, several studies have shown that the CONUT score has prognostic value for hematological malignancies, such as diffuse large B‐cell lymphoma (DLBCL), peripheral T‐cell lymphoma (PTCL), and multiple myeloma (MM). 15 , 16 , 17 However, there have been no studies exploring its prognostic value in patients with ENKTL. In this study, we evaluated the predictive value of the CONUT score toward the prognosis of ENKTL patients receiving asparaginase‐containing regimens.…”

Section: Introductionmentioning

confidence: 99%

“…As an efficient index for the early detection and ongoing screening of malnutrition, the controlling nutritional status (CONUT) score, originally reported in 2005, consists of total lymphocyte counts (TL), total cholesterol level (T‐CHOL), and serum albumin (ALB) 14 . Currently, several studies have shown that the CONUT score has prognostic value for hematological malignancies, such as diffuse large B‐cell lymphoma (DLBCL), peripheral T‐cell lymphoma (PTCL), and multiple myeloma (MM) 15–17 . However, there have been no studies exploring its prognostic value in patients with ENKTL.…”

Section: Introductionmentioning

confidence: 99%

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A controlling nutritional status score is an independent predictor for patients with newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma based on asparaginase‐containing regimens

Ren

Chen

et al. 2023

Cancer Medicine

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Background The controlling nutritional status (CONUT) score is a nutritional index that combines serum albumin, total cholesterol, and lymphocyte counts. The potential value of CONUT score for predicting clinical outcomes in patients with nasal‐type extranodal NK/T‐cell lymphoma (ENKTL) has not been explored. Methods This study included 374 ENKTL patients treated with asparaginase‐containing regimens from September 2012 to September 2017. Clinical characteristics, treatment efficacy, prognostic factors, and the predictive value of CONUT score were analyzed. Results The complete response (CR) and overall response rate (ORR) were 54.8% and 74.6%, respectively. Patients with CONUT scores <2 had higher CR and ORR compared to patients with scores ≥2 (69.1% vs. 48.9% for CR, p = 0.001; 90.0% vs. 74.6% for ORR, p < 0.001). The 5‐year overall survival (OS) and progression‐free survival (PFS) rates were 61.9% and 57.3%, respectively. Patients with CONUT scores <2 had better survival outcomes than those with scores ≥2 (5‐year OS, 76.1% vs. 56.0%, p < 0.001; 5‐year PFS, 74.4% vs. 50.1%, p < 0.001). CONUT score ≥2 was identified as an independent poor prognostic factor for both OS and PFS. A CONUT score ≥2 was also associated with poorer survival outcomes in low‐risk ENKTL patients. Conclusion A CONUT score ≥2 is a prognostic marker for poor survival in patients with ENKTL and could be used to stratify risk in low‐risk patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A controlling nutritional status score is an independent predictor for patients with newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma based on asparaginase‐containing regimens

Ren

Chen

et al. 2023

Cancer Medicine

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“…As the most commonly used clinical index in the CONUT score to evaluate the nutritional status of the patient's body functions, Alb is reduced in patients with lymphoma. The possible mechanisms for Alb reduction could be (16)(17)(18), ( 1) increased catabolism of Alb, (2) loss of Alb due to changes in vascular permeability from the rapid increase of excessive inflammatory factors in the peripheral blood of patients as a result of local inflammatory cascade after the development of lymphoma. TC, which is an important component of the cell membrane, is associated with the proliferation, migration, and immune response of malignant tumor cells and can promote the recognition of tumor cells by immune cells by enhancing the antigen presentation function of monocytes (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of nutritional status in patients with human immunodeficiency virus infection-related lymphoma

Liu

Hu²,

Lv³

et al. 2022

Front. Nutr.

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ObjectiveTo investigate the predictive value of nutritional status on the prognosis of patients with human immunodeficiency virus (HIV) infection-related lymphoma.Materials and methodsA total of 149 patients with HIV infection-related lymphoma who were admitted to our hospital from August 2012 to May 2022 were selected as research subjects. Based on the patient prognosis, they were divided into a poor prognosis group (n = 30) and a good prognosis group (n = 119). General data from patients in both groups were collected, and the nutritional status of the patients was evaluated using the Controlling Nutritional Status (CONUT) score. Factors affecting the prognosis of HIV infection-related lymphoma were analyzed using univariate and multivariate analyses, and a prediction model was developed based on the analyzed factors. The receiver operating characteristic (ROC) curve was used to analyze the prediction model of the CONUT score alone and included the CONUT score in the prognosis of patients with HIV infection-related lymphoma. The predictive value of the data was assessed, and a survival curve was drawn to compare the survival of patients with different nutritional statuses.ResultsThere were significant differences in age, B symptoms, treatment conditions, International Prognostic Index (IPI), pathological stage, Eastern Collaborative Tumor Group physical status score (ECOG PS), CD4+ cell count, β2 microglobulin, and lactate dehydrogenase (LDH) between the poor prognosis group and the good prognosis group (p < 0.05). The CONUT score of the poor prognosis group was higher than that of the good prognosis group, and the difference was statistically significant (p < 0.05). A univariate analysis demonstrated that the age, B symptoms, treatment status, IPI, pathological stage, ECOG PS, CD4+ cell count, β2 microglobulin, LDH, and CONUT score were prognostic factors for patients with HIV infection-related lymphoma (p < 0.05). The results of a multivariate regression analysis demonstrated that the age, B symptoms, treatment status, IPI, pathological stage, ECOG PS, and CONUT score were independent risk factors for the prognosis of patients with HIV infection-related lymphoma (p < 0.05). The prediction model was constructed according to the multivariate Cox regression analysis results. The model formula was as follows: Logit(p) = −10.687 + 1.728 × age + 1.713 × B symptoms + 1.682 × treatment status + 1.810 × IPI + 1.643 × pathological stage + 1.584 × ECOG PS + 1.779 × CONUT score. The ROC curve was used to analyze the predictive value of the CONUT score alone and the predictive model including the CONUT score on the prognosis of patients with HIV infection-related lymphoma. The predictive value of the prognosis of patients with tumors was higher (p < 0.05). According to the results of the ROC curve analysis, the patients were divided into a high CONUT group (CONUT > 6.00 points, n = 31) and a low CONUT group (CONUT ≤ 6.00 points, n = 118) based on the Optimum threshold of the CONUT score. The survival curve showed that the survival rate of the high CONUT group was lower than that of the low CONUT group (p < 0.05).ConclusionThe poor prognosis of HIV infection-related lymphoma is related to nutritional status, which is an independent risk factor affecting the prognosis of patients and can be used as a practical indicator to predict the prognosis of patients.

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Hemoglobin‐platelet index as a prognostic factor in patients with peripheral T‐cell lymphoma

Kanemasa

Sasaki

et al. 2023

eJHaem

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Peripheral T‐cell lymphoma (PTCL) is a heterogeneous group of aggressive lymphomas with a poor prognosis. The International Prognostic Index (IPI) and the Prognostic Index for PTCL‐unspecified (PIT) is used to predict the prognosis of PTCL. The hemoglobin‐platelet index (HPI), based on anemia and thrombocytopenia status, is associated with the prognosis of diffuse large B‐cell lymphoma. However, its significance in terms of predicting the prognosis of PTCL has not been fully investigated. We herein retrospectively analyzed 100 patients with newly diagnosed PTCL in our department. At a median follow‐up of 3.2 years, the median progression‐free survival (PFS) and overall survival (OS) was 0.72 (95% confidence interval [CI]: 0.56–1.2) years and 2.0 (95% CI: 1.5–4.7) years, respectively. Multivariate analysis revealed that elevated lactic dehydrogenase (LDH) and hypoalbuminemia were independent adverse variables for PFS. The HPI showed significant predictive value for both PFS and OS. As a new prognostic model comprising the HPI, LDH, and albumin, the LA‐HPI allowed the stratification of patients into four distinct risk subgroups: low risk (zero risk factors), low‐intermediate risk (one risk factors), high‐intermediate risk (two or three risk factors), or high risk (four risk factors). The PFS and OS differed significantly among the patients by the LA‐HPI score. The LA‐HPI demonstrated better predictive performance compared to the IPI, PIT, and HPI. Our data demonstrated the prognostic utility of the HPI in patients with PTCL. The LA‐HPI, incorporating four readily obtainable parameters, exhibited superior performance compared to traditional indices.

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Prognostic impact of the controlling nutritional status score in patients with peripheral T-cell lymphoma

Cited by 11 publications

References 19 publications

A controlling nutritional status score is an independent predictor for patients with newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma based on asparaginase‐containing regimens

A controlling nutritional status score is an independent predictor for patients with newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma based on asparaginase‐containing regimens

Prognostic value of nutritional status in patients with human immunodeficiency virus infection-related lymphoma

Hemoglobin‐platelet index as a prognostic factor in patients with peripheral T‐cell lymphoma

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