Prognostic impact of supraventricular premature complexes in community-based health checkups: The Ibaraki Prefectural Health Study

Murakoshi, Nobuyuki; Xu, DongZhu; Sairenchi, Toshimi; Igarashi, Miyako; Irie, Fujiko; Tomizawa, Takuji; Tada, Hiroshi; Sekiguchi, Yukio; Yamagishi, Kazumasa; Iso, Hiroyasu; Yamaguchi, Iwao; Ota, Hitoshi; Aonuma, Kazutaka

doi:10.1093/eurheartj/ehu407

Cited by 58 publications

(64 citation statements)

References 29 publications

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“…In addition to demonstrating replication in our replication analyses, our findings are consistent with previous literature describing a different population: In a secondary analysis of an important recent study of over 60 000 Japanese individuals participating in annual health exams, Murakoshi et al demonstrated a greater risk of AF in those with a supraventricular premature contraction on baseline, standard resting 12‐lead ECG 26. These findings complement ours well.…”

Section: Discussionsupporting

confidence: 92%

Ectopy on a Single 12‐Lead ECG, Incident Cardiac Myopathy, and Death in the Community

Nguyen

Vittinghoff

Dewland

et al. 2017

JAHA

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BackgroundAtrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12‐lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12‐lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality.Methods and ResultsWe utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort. The ARIC (Atherosclerosis Risk in Communities Study), the replication cohort, captured data from 15 792 participants over a median of 22 years. In the CHS, multivariable analyses revealed that a baseline 12‐lead ECG premature atrial contraction predicted a 60% increased risk of atrial fibrillation (hazard ratio, 1.6; 95% CI, 1.3–2.0; P<0.001) and a premature ventricular contraction predicted a 30% increased risk of heart failure (hazard ratio, 1.3; 95% CI, 1.0–1.6; P=0.021). In the negative control analyses, neither predicted incident myocardial infarction. A premature atrial contraction was associated with a 30% increased risk of death (hazard ratio, 1.3; 95% CI, 1.1–1.5; P=0.008) and a premature ventricular contraction was associated with a 20% increased risk of death (hazard ratio, 1.2; 95% CI, 1.0–1.3; P=0.044). Similarly statistically significant results for each analysis were also observed in ARIC.ConclusionsBased on a single standard ECG, a premature atrial contraction predicted incident atrial fibrillation and death and a premature ventricular contraction predicted incident heart failure and death, suggesting that this commonly used test may predict future disease.

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Section: Discussionsupporting

confidence: 92%

Ectopy on a Single 12‐Lead ECG, Incident Cardiac Myopathy, and Death in the Community

Nguyen

Vittinghoff

Dewland

et al. 2017

JAHA

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“…A high burden of premature atrial contractions was reduced by RDN. The herein reported study provides the first data of RDN not only on LA morphology but also on the occurrence of PAC, potentially representing triggers for AF (29,30). Because of the role of the autonomic nervous system in the pathophysiology of AF (31), the therapeutic potential of RDN in beneficially modifying atrial remodeling and thus, potentially, arrhythmogenesis has been earlier speculated (32,33 (10) and clinical (37) data also report positive effects on unstable ventricular rhythms, that is, electrical storm (38).…”

Section: Discussionmentioning

confidence: 88%

Atrial Remodeling Following Catheter-Based Renal Denervation Occurs in a Blood Pressure– and Heart Rate–Independent Manner

Schirmer

Sayed

Reil

et al. 2015

JACC: Cardiovascular Interventions

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“…A Japanese cohort, the Ibaraki Prefectural Health Study, showed an 8% prevalence of PACs in the included individuals (n = 63 197). The higher prevalence of PACs may be explained by the more narrow range and older average age of the population (40–79 years), and possibly also the ethnicity of the individuals of the large‐scale database from the Ibaraki Prefectural Health Study . However, ≥1 PAC was found on 24‐hour Holter monitoring in 99% of all white, middle‐aged individuals.…”

Section: Discussionmentioning

confidence: 99%

Population‐based values and abnormalities of the electrocardiogram in the general Dutch population: The LifeLines Cohort Study

Ende

Siland

Snieder

et al. 2017

Clinical Cardiology

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Background Our aim is to present average values and prevalence of electrocardiographic (ECG) abnormalities among the general Dutch population in the LifeLines Cohort. Hypothesis The ECG values previously studied in the Caucasian population of smaller cohorts will be confirmed with ECG data from LifeLines. Methods ECG data of 152 180 individuals age 18 to 93 years were available. Individuals with cardiovascular risk factors were excluded to analyze the healthy population. Average values of the ECG for the healthy population were presented as means with 95% and 99% confidence intervals and as medians with first and 99th percentiles. Results Median heart rate was highest in the youngest and oldest individuals of the healthy population. Median duration of P wave, PQ interval, and QRS duration were longer in males compared with females. In contrast, median QT interval corrected for heart rate was higher in females. In general, the above‐mentioned parameters increased with age. The prevalences of ECG abnormalities adjusted for the Dutch population were 0.9% for atrial fibrillation or flutter, 1.4% for premature atrial complexes, 0.5% for myocardial infarction, 2.1% for ventricular premature complexes, 1.0% for left ventricular hypertrophy, 8.1% for P‐R interval >200 ms, and 0.8% for bundle branch block. Conclusions Our study provides an overview of average values and ECG abnormalities and confirms data of previous smaller studies. In addition, we evaluate the age‐ and sex‐dependent normal limits of the P wave and QRS duration and confirm in detail the frontal plane QRS‐T angle on the ECG.

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Prognostic impact of supraventricular premature complexes in community-based health checkups: The Ibaraki Prefectural Health Study

Abstract: The presence of SVPCs in 12-lead electrocardiograms was a strong predictor of AF development, and associated with increased risk of CVD in general population.

Cited by 58 publications

References 29 publications

Ectopy on a Single 12‐Lead ECG, Incident Cardiac Myopathy, and Death in the Community

Ectopy on a Single 12‐Lead ECG, Incident Cardiac Myopathy, and Death in the Community

Atrial Remodeling Following Catheter-Based Renal Denervation Occurs in a Blood Pressure– and Heart Rate–Independent Manner

Population‐based values and abnormalities of the electrocardiogram in the general Dutch population: The LifeLines Cohort Study

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