Prognostic impact of serum transthyretin in patients with non‑small cell lung cancer

Shimura, Tatsuo; Shibata, Masahiko; Inoue, Takuya; Owada-Ozaki, Yuki; Yamaura, Takumi; Muto, Satoshi; Hasegawa, T.; Shio, Yutaka; Suzuki, Hiroyuki

doi:10.3892/mco.2019.1837

Cited by 6 publications

(4 citation statements)

References 23 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2A ). With this dataset, we could confirm several markers on a protein level that had previously been shown on RNA level 23 , such as mucin-5B (MUC5B), a glycoprotein that is secreted in the lung and is associated with poor prognosis in ADC 24 , kininogen 1 (KNG1), and serum transthyretin (TTR), which has been shown to be associated with poor outcome 25 . In SCC we could confirm apolipoprotein 1 (APOA1) which has previously been described as inversely correlated with the risk of lung cancer 26 .…”

Section: Resultssupporting

confidence: 53%

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories

et al. 2021

View full text Add to dashboard Cite

Formalin-fixed paraffin-embedded (FFPE) tissues are a valuable resource for retrospective clinical studies. Here, we evaluate the feasibility of (phospho-)proteomics on FFPE lung tissue regarding protein extraction, quantification, pre-analytics, and sample size. After comparing protein extraction protocols, we use the best-performing protocol for the acquisition of deep (phospho-)proteomes from lung squamous cell and adenocarcinoma with >8,000 quantified proteins and >14,000 phosphosites with a tandem mass tag (TMT) approach. With a microscaled approach, we quantify 7,000 phosphosites, enabling the analysis of FFPE biopsies with limited tissue amounts. We also investigate the influence of pre-analytical variables including fixation time and heat-assisted de-crosslinking on protein extraction efficiency and proteome coverage. Our improved workflows provide quantitative information on protein abundance and phosphosite regulation for the most relevant oncogenes, tumor suppressors, and signaling pathways in lung cancer. Finally, we present general guidelines to which methods are best suited for different applications, highlighting TMT methods for comprehensive (phospho-)proteome profiling for focused clinical studies and label-free methods for large cohorts.

show abstract

Section: Resultssupporting

confidence: 53%

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Kaplan Meier analysis further showed that OS and DFS in patients with high TTR were signi cantly longer than those in patients with low TTR. This is consistent with the previous results that the abnormal expression of TTR is associated with poor clinical prognosis in lung cancer and gastrointestinal cancers [19,20]. Meanwhile, subgroup analysis showed that in patients with stage I and II lung cancer, OS and DFS of patients with high TTR were signi cantly longer than those with low TTR, indicating that TTR also has a value prognosis for early lung cancer.…”

Section: Discussionsupporting

confidence: 92%

The prognostic role of tissue and serum transthyretin expression in patients with surgically resected non-small cell lung cancer

Zhong

Zou

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Transthyretin (TTR) is a traditional biomarker for nutritional and inflammatory. The present study was conducted to explore the clinical value of TTR in serum and tumor tissue in patients with surgically resected non-small cell lung cancer (NSCLC). Methods TTR expression levels were determined in paraffin-embedded NSCLC tissue specimens using immunohistochemistry. Serum TTR expression levels were measured from patients with lung cancer and healthy controls using enzyme-linked immunosorbent assay (ELISA). Results The expression levels of TTR were significantly higher in lung cancer tissues than in paracancerous tissues, and TTR expression was significantly associated with TNM stage (P = 0.002) and lymph node metastasis (P = 0.032). Multivariate analysis revealed that increased expression of TTR was an independent risk factor for overall survival (OS) (P = 0.012) and disease-free survival (DFS) (P = 0.011) in NSCLC patients. The expression levels of TTR in serum from lung cancer patients were lower than those of healthy controls (P = 0.002). A high expression of TTR in tumor tissue was associated with a higher serum level (r = 0.799, P = 0.001). Conclusions TTR expression is upregulated in lung cancer patients, and its expression was correlated with poor prognosis in NSCLC patients.

show abstract

“…Several publications reported a role for prealbumin in predicting prognosis (mostly survival) in various clinical conditions such as gastric cancer [37], lung cancer [38] and cardiovascular diseases [39].…”

Section: Serum Visceral Proteins As Biomarkers Of the Nutritional mentioning

confidence: 99%

Nutritional Laboratory Markers in Malnutrition

Keller¹

2019

JCM

444

353

View full text Add to dashboard Cite

Serum visceral proteins such as albumin and prealbumin have traditionally been used as markers of the nutritional status of patients. Prealbumin is nowadays often preferred over albumin due to its shorter half live, reflecting more rapid changes of the nutritional state. However, recent focus has been on an appropriate nutrition-focused physical examination and on the patient’s history for diagnosing malnutrition, and the role of inflammation as a risk factor for malnutrition has been more and more recognized. Inflammatory signals are potent inhibitors of visceral protein synthesis, and the use of these proteins as biomarkers of the nutritional status has been debated since they are strongly influenced by inflammation and less so by protein energy stores. The current consensus is that laboratory markers could be used as a complement to a thorough physical examination. Other markers of the nutritional status such as urinary creatinine or 3-methylhistidine as indicators of muscle protein breakdown have not found widespread use. Serum IGF-1 is less influenced by inflammation and falls during malnutrition. However, its concentration changes are not sufficiently specific to be useful clinically as a marker of malnutrition, and serum IGF-1 has less been used in clinical trials. Nevertheless, biomarkers of malnutrition such as prealbumin may be of interest as easily measurable predictors of the prognosis for surgical outcomes and of mortality in severe illnesses.

show abstract

Prognostic impact of serum transthyretin in patients with non‑small cell lung cancer

Cited by 6 publications

References 23 publications

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories

Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories

The prognostic role of tissue and serum transthyretin expression in patients with surgically resected non-small cell lung cancer

Nutritional Laboratory Markers in Malnutrition

Contact Info

Product

Resources

About