Prognostic Impact of Redo Transcatheter Mitral Valve Repair for Recurrent Mitral Regurgitation

Sugiura, Akira; Weber, Marcel; Tabata, Noriaki; Goto, Tadahiro; Öztürk, Can; Hammerstingl, Christoph; Sinning, Jan‐Malte; Werner, Nikos; Nickenig, Georg

doi:10.1016/j.amjcard.2020.06.025

Cited by 6 publications

(11 citation statements)

References 23 publications

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“…Kreidel et al 12 reported a high mortality rate at 3 months (62%). In contrast, Sugiura et al 19 showed more favorable results with a mortality rate of 10.5% at 1 year and composite of mortality and rehospitalization for CHF in 22.3%. In addition, the aforementioned manuscript compared a cohort of 43 redo interventions with 43 matched controls with residual MR > 2 during follow‐up, showing a significant reduction of both mortality and CHF admissions at 1 year 19 …”

Section: Discussionmentioning

confidence: 90%

“…The present results showed higher procedural success (87%) compared to the previous series which ranged among 62% and 79%. 12,15,19 Clinical outcomes are variable among series. Kreidel et al 12 reported a high mortality rate at 3 months (62%).…”

Section: Discussionmentioning

confidence: 99%

“…Progressive left ventricle remodeling, leaflet perforation or partial detachment have been described as potential mechanisms for MR progression after edge-to-edge repair. [12][13][14][15][16][17][18][19] Repeated edge-toedge TMVR procedures have been proposed as a valid strategy for correcting some residual MRs. [12][13][14][15][16][17][18][19] However, evidence regarding redo TMVR for recurrent mitral regurgitation is scarce. 14 The present manuscript ought to describe the complete experience of repeated Mitraclip interventions in eight high-volume TMVR centers in Spain.…”

Section: Introductionmentioning

confidence: 99%

“…In some cases, these residual MR are not present after the initial procedure and show up during the follow‐up period. Progressive left ventricle remodeling, leaflet perforation or partial detachment have been described as potential mechanisms for MR progression after edge‐to‐edge repair 12‐19 . Repeated edge‐to‐edge TMVR procedures have been proposed as a valid strategy for correcting some residual MRs 12‐19 .…”

Section: Introductionmentioning

confidence: 99%

“…Progressive left ventricle remodeling, leaflet perforation or partial detachment have been described as potential mechanisms for MR progression after edge‐to‐edge repair 12‐19 . Repeated edge‐to‐edge TMVR procedures have been proposed as a valid strategy for correcting some residual MRs 12‐19 . However, evidence regarding redo TMVR for recurrent mitral regurgitation is scarce 14 .…”

Section: Introductionmentioning

confidence: 99%

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Procedural and clinical outcomes after repeat edge‐to‐edge transcatheter mitral valve repair

Freixa

Estévez‐Loureiro

Pascual

et al. 2022

Cathet Cardio Intervent

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Background and Objectives Evidence regarding redo percutaneous interventions for recurrent mitral regurgitation is scarce. We ought to evaluate procedural and clinical outcomes of repeated edge‐to‐edge transcatheter mitral valve repair (TMVR) interventions. Methods This multicenter study collected individual data from eight high‐volume TMVR Centers in Spain. Between 2012 and 2020, all patients undergoing a second edge‐to‐edge TMVR intervention (Redo) were included in the study. Results Among a total of 1028 procedures, 31 patients (3%) with residual MR ≥ 3 at follow‐up underwent a second procedure (Redo). Redo intervention was mainly conducted between the first and second year after the first procedure. The most common cause of MR progression was partial detachment (46.7%) followed by LV remodeling (35.5%). Procedural success was achieved in 87% of cases. After a mean follow‐up of 1.75 ± 1.54 years, all‐cause and cardiovascular mortality were 48.1% and 25%, respectively. Nearly half of the patients (48.1%) required at least one hospital admission for CHF within the follow‐up period. However, most of the patients presented symptomatic improvement as depicted by an NYHA class ≤2. Elective mitral surgery was conducted in only one patient at follow‐up due to insufficient MR reduction. Conclusions According to our findings, redo edge‐to‐edge TMVR interventions were feasible and safe with a high procedural success rate. Clinical and echocardiographic follow‐up showed however modest long‐term results in this specific setting.

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Section: Discussionmentioning

confidence: 90%