Prognostic Impact of Postoperative Serum CA 19-9 Levels in Patients with Resectable Pancreatic Cancer

Abstract

Postoperative CA 19-9 level was associated with positive surgical margin and hepatic or peritoneal recurrence and may be a useful predictor for survival in patients with pancreatic cancer.

Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative 18F-FDG PET/CT in Patients with Pancreatic Cancer

“…The results of our study also showed that there were greater significant differences in MTV and TLG than in SUVmax between patients with and without recurrence and that only MTV and TLG were independent prognostic factors for both RFS and OS among the 18 F-FDG PET/CT parameters analyzed. Several prognostic factors for predicting recurrence of pancreatic cancer have been suggested, and tumor size, pT stage, lymph node metastasis, tumor differentiation, lymphovascular invasion, and serum CA19-9 level have been shown to be significant predictors (1,(7)(8)(9). Because exact tumor size, pT stage, presence of lymph node metastasis, tumor differentiation, and lymphovascular invasion of the tumor can be assessed only by examining the surgical specimen, they cannot be used to predict clinical outcomes before surgery.…”

“…Moreover, most patients who undergo resection with curative intent develop recurrence usually in the first 6-12 mo of the surgery (4)(5)(6). Several prognostic factors for pancreatic cancer recurrence have previously been reported including tumor size, T stage, lymph node metastasis, tumor differentiation, lymphovascular invasion, involvement of the surgical margin, and serum carbohydrate antigen 19-9 (CA19-9) level (1,(7)(8)(9).…”

Impact of Preoperative Biliary Drainage on Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma: A Multicenter Observational Study

“…5 Our data from seven high-volume surgical institutions in Japan during a 22 demonstrated that the presence of perineural invasion was the single independent variable significantly associated with an increased risk of peritoneal recurrence. Hata et al 23 showed that the postoperative CA19-9 level was associated with positive surgical margins and hepatic or peritoneal recurrence.…”

microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis

“…However, there is often discordance between histological characteristics, tumour stage and survival [4,5]. Serum carbohydrate antigen remains the only biomarker used in clinical practice to monitor disease progression during PDAC treatment [2], with elevated levels post-operatively correlated with resection margin positivity (R1) and development of distant metastases [6].…”