“…Lymphovascular invasion has been defined as the unequivocal presence of tumor cells within endothelial-lined spaces with no underlying muscular walls 12,15,18,19 or as the presence of tumor emboli in small intraprostatic vessels 14 ( Figure 2a), as most reports have suggested a predilection of tumor emboli for small vessels defined by their endothelial lining but with little or no underlying muscular wall. 16 In many studies, except two, 17,67 no attempt has been made to distinguish between lymphatic and vascular channels because of the difficulties of differentiating between them on routine light microscopic examination 12,14,[17][18][19] and as, for practical purposes, either lymphatic or venous involvement implies ultimate reach of tumor to the circulatory system.…”