Prognostic impact of hs-CRP and IL-6 in patients undergoing radiofrequency catheter ablation for atrial fibrillation

Abstract

In patients with a history of paroxysmal or persistent AF treated with RF catheter ablation, elevated levels of IL-6 and hs-CRP before ablation are independent predictors of recurrence of AF.

Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation

“…In a multivariate logistic regression analysis, the baseline value of plasma YKL-40 was not an independent predictor of recurrent AF after catheter ablation (P = 0.28). The procedure (P = 0.03) and the left atrium diameter (P = 0.02) were still independent predictors of recurrent AF as previously reported [10,24] (Table 3).…”

“…In the present population we have previously shown [10] that plasma levels of IL-6 before catheter ablation were an independent predictor of recurrence of AF. In the present study we found that baseline plasma YKL-40 correlated significantly with baseline plasma IL-6, but not with baseline hs-CRP.…”

“…Analyses of plasma levels of hs-CRP and IL-6 have previously been described in the present study population, and the data have been published [10]. In brief, hs-CRP analysis was performed using Modular, P-modul, Tina-quant C-reactive protein (latex) high sensitivity assay (Roche, Germany).…”

“…Low plasma levels of inflammatory markers such as high sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) have been shown to predict successful restoration of sinus rhythm (SR) in patients with AF after electrical cardioversion (CV) [5][6][7][8][9] and catheter ablation [10]. YKL-40 is a 40 kDa heparin-, collagen-, and chitinbinding plasma glycoprotein.…”

Inflammation and C-Reactive Protein in Atrial Fibrillation: Cause or Effect?

“…Other investigators associated serum IL-6 levels with AF after CABG, 51 after cardioversion, 52 and after radiofrequency catheter ablation. 53 Aviles and associates 22 performed a cross-sectional study of 5,806 subjects and reported that baseline levels of CRP were higher in patients affected by AF even after adjustment for multiple variables potentially associated with AF, and that CRP level is a strong predictor of future AF. Among 5,491 patients included in the longitudinal study, 897 (16%) developed AF during the follow-up period (median duration, 7.8 yr).…”