Prognostic factors related to delayed healing of venous leg ulcer treated with compression therapy

Karanikolić, Vesna; Karanikolić, Aleksandar; Petrović, Dejan; Stanojević, Milenko

doi:10.1016/j.dsi.2015.04.005

Cited by 16 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study failed to identify any patient factors (age, ethnicity, obesity, smoking history, presence of DM and PAD, prior wound history) that were significant predictors of wound healing. These findings are similar to the study by Karanikolic et al on 100 patients with VLUs treated with multiple‐layer compression bandages and elastic stockings 30 . It is well established that DM is associated with poor healing, either because of the metabolic state or complications of the disease, such as micro‐ and macroangiopathy.…”

Section: Discussionsupporting

confidence: 90%

A prospective study on the wound healing and quality of life outcomes of patients with venous leg ulcers in Singapore—Interim analysis at 6 month follow up

Chan

Wang

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

Venous leg ulceration results in significant morbidity. However, the majority of studies conducted are on Western populations. This study aims to evaluate the wound healing and quality of life for patients with venous leg ulcers (VLUs) in a Southeast Asian population. This is a multi‐centre prospective cohort study from Nov 2019 to Nov 2021. All patients were started on 2‐ or 4‐layer compression bandage and were reviewed weekly or fortnightly. Our outcomes were wound healing, factors predictive of wound healing and the EuroQol 5‐dimensional 5‐level (EQ‐5D‐5L) health states. Within our cohort, there were 255 patients with VLU. Mean age was 65.2 ± 11.6 years. Incidence of diabetes mellitus was 42.0%. Median duration of ulcer at baseline was 0.30 years (interquartile range 0.136–0.834). Overall, the median time to wound healing was 4.5 months (95% confidence interval [CI]: 3.77–5.43). The incidence of complete wound healing at 3‐ and 6‐month was 47.0% and 60.9%, respectively. The duration of the wound at baseline was independently associated with worse wound healing (Hazard ratio 0.94, 95% CI: 0.89–0.99, P = .014). Patients with healed VLU had a significantly higher incidence of perfect EQ‐5D‐5L health states at 6 months (57.8% vs 13.8%, P < .001). We intend to present longer term results in subsequent publications.

show abstract

Section: Discussionsupporting

confidence: 90%

A prospective study on the wound healing and quality of life outcomes of patients with venous leg ulcers in Singapore—Interim analysis at 6 month follow up

Chan

Wang

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…A large proportion of patients (n = 10) received antibiotics immediately postoperatively. Given the interest in potential prognostic factors for healing in previous studies 4,11 and in a retrospective cohort study of wounds, 12 this could be explored in the future RCT. This study found that 40% of patients had primary venous disease, with a further quarter of the patients having unknown venous status.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Healing of ExcisionAl wounds on Lower legs by Secondary intention (HEALS) cohort study. Part 1: a multicentre prospective observational cohort study in patients without planned compression

Pynn

Ransom

Walker

et al. 2022

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

Background. There is no agreed treatment pathway following excision of keratinocyte cancer (KC). Compression therapy is considered beneficial for secondary intention healing on the lower leg; however, there is a lack of supportive evidence. To plan a randomized controlled trial (RCT), suitable data are needed. We report a multicentre prospective observational cohort study in this patient population with the intention of informing a future trial design. Aim. To estimate the time to healing in wounds healing by secondary intention without planned postoperative compression, following excision of KC on the lower leg; to characterize the patient population, including factors affecting healing; and to assess the incidence of complications. Methods. This was a multicentre prospective observational cohort study. Inclusion criteria were age ≥ 18 years with planned excision of KC on the lower leg and healing by secondary intention, an ankle-brachial pressure index (ABPI) of ≥ 0.8; and written informed consent. Exclusion criteria included planned excision with primary closure, skin graft or flap; compression therapy for another indication; planned compression; inability of patient to receive, comply with or tolerate high compression; or a suspected diagnosis other than KC.Results. This study recruited 58 patients from 9 secondary care dermatology clinics. In the analysis population (n = 53), mean age was 81 years (range 25-97 years), median time to healing was 81 days (95% CI 73-92) and 45 patients (84.9%) had healing of the wound at the 6-month follow-up. The healing prognostic factors were wound parameters and ABPI. Wound infections occurred in 16 participants (30.2%). Four patients (7.5%) were admitted to hospital; three because of an infection and one because of a fall.

show abstract

“…La enfermedad venosa crónica es más frecuente en el sexo femenino, lo cual facilita la aparición de ulceras vasculares (11,12). Márquez et al (13) reporto que el promedio de edad de la población fue de 54 años, sin embargo, Karanicolic (14) menciono que en su su estudio fue de 63 años, siendo este último dato similar a lo encontrado.…”

Section: Discussionunclassified

Caracterización clínica de pacientes con recurrencia de úlcera por enfermedad venosa crónica.

Silva¹,

Suárez²,

Quintero³

et al. 2021

Ciencia e Innovación en Salud

View full text Add to dashboard Cite

Introducción: La enfermedad venosa crónica es una patología derivada de alteraciones anatómicas o funcionales del sistema venoso. El objetivo de este estudio era determinar las características de los pacientes con recurrencia de úlcera por enfermedad venosa crónica en usuarios del programa clínica de heridas de un hospital de tercer nivel de Tunja. Métodos: Se realizó un estudio descriptivo, retrospectivo y de corte transversal en el periodo 2017 a 2019, donde se incluyeron pacientes mayores de 18 años de edad con diagnostico ulcera vascular por enfermedad venosa crónica. Resultados: La prevalencia de recurrencia fue de 15.7%. La media de edad de los participantes fue de 65 años, donde el 72.7% eran mujeres y el 77.3% de los participantes vivían solos. La hipertensión (72,7%) y el sobrepeso (45,5%) fueron las comorbilidades que se presentaban con mayor frecuencia. La extremidad inferior más afectada fue la izquierda con 68.2%. Las personas permanecían 50.9 minutos al día con la extremidad elevada y 6.6 horas al día en bipedestación. Conclusiones: La prevalencia de recurrencia de úlcera por enfermedad venosa crónica en el presente estudio es menor a la reportada en la literatura, donde se ve afectada la población femenina, con 65 años de edad, asociado a múltiples comorbilidades como el sobrepeso, la desnutrición, el tabaquismo, la dislipidemia, entre otras. Afecta con mayor frecuencia el miembro inferior izquierdo y los manejos más utilizados son los quirúrgicos (varicosafenectomía) y la terapia compresiva a presión media y alta. A partir de este estudio se invita a otras instituciones a evaluar los programas de manejo de heridas con el fin de analizar el impacto y conocer este grupo poblacional.

show abstract

Prognostic factors related to delayed healing of venous leg ulcer treated with compression therapy

Cited by 16 publications

References 14 publications

A prospective study on the wound healing and quality of life outcomes of patients with venous leg ulcers in Singapore—Interim analysis at 6 month follow up

A prospective study on the wound healing and quality of life outcomes of patients with venous leg ulcers in Singapore—Interim analysis at 6 month follow up

Healing of ExcisionAl wounds on Lower legs by Secondary intention (HEALS) cohort study. Part 1: a multicentre prospective observational cohort study in patients without planned compression

Caracterización clínica de pacientes con recurrencia de úlcera por enfermedad venosa crónica.

Contact Info

Product

Resources

About