Prognostic Factors on Overall Survival of Newly Diagnosed Metastatic Nasopharyngeal Carcinoma

Li, Jia Xin; Huang, Shao Min; Wen, Bixiu; Lu, Tai Xiang

doi:10.7314/apjcp.2014.15.7.3169

Cited by 20 publications

(15 citation statements)

References 19 publications

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“…Since the well-known tumor-node-metastasis (TNM) staging system could not provide prognostic information, a series of clinical characteristics and laboratory biomarkers associated with prognosis of patients with metastatic NPC have been explored in several studies [13–19]. Hemoglobin, performance status (PS), and disease-free interval (DFI) were first identified as prognostic factors for disseminated NPC by Toh et al [20] in 2005.…”

Section: Introductionmentioning

confidence: 99%

The Ratio of C-Reactive Protein/Albumin is a Novel Inflammatory Predictor of Overall Survival in Cisplatin-Based Treated Patients with Metastatic Nasopharyngeal Carcinoma

Sun

Xia

et al. 2017

Disease Markers

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The C-reactive protein/albumin (CRP/Alb) ratio has been recently identified as a prognostic factor in various cancers, whereas its role remains unclear in metastatic nasopharyngeal carcinoma (NPC). The current study retrospectively analyzed 148 patients with metastatic NPC who underwent cisplatin-based chemotherapy and further evaluated the prognostic value of the CRP/Alb ratio and its association with clinical characteristics in these patients. The optimal cut-off value was 0.189 for the CRP/Alb ratio. The high CRP/Alb ratio was significantly associated with elevated NLR, platelet-to-lymphocyte ratio (PLR), and EBV-DNA levels and decreased haemoglobin level (all p < 0.05). The results of multivariate analysis showed that the CRP/Alb ratio was an independent prognostic factor of overall survival. Patients with a high CRP/Alb ratio (≥0.189) had a 1.867 times (p = 0.024, 95% CI = 1.085–3.210) greater risk of mortality compared with those with a low CRP/Alb ratio (<0.189). In addition, combining the CRP/Alb ratio with GPS could accurately discriminate the prognosis of our patients. Our results suggested that the CRP/Alb ratio is a feasible and inexpensive tool for predicting survival outcomes and is a valuable coadjutant for the GPS to further identify differences in survivals of patients with metastatic NPC.

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Section: Introductionmentioning

confidence: 99%

The Ratio of C-Reactive Protein/Albumin is a Novel Inflammatory Predictor of Overall Survival in Cisplatin-Based Treated Patients with Metastatic Nasopharyngeal Carcinoma

Sun

Xia

et al. 2017

Disease Markers

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“…Despite the majority of patients with metastatic NPC typically experiencing a good initial response to chemotherapy, frequent recurrences can occur due to the development of multidrug resistance (MDR) against chemotherapeutic agents (7). As a result, the prognosis for patients with metastatic NPC remains poor, with a 3-year overall survival rate of 30-40% (6,8), which emphasizes the requirement for novel therapies that target drug-resistant NPC.…”

Section: Introductionmentioning

confidence: 99%

microRNA-125b reverses the multidrug resistance of nasopharyngeal carcinoma cells via targeting of Bcl-2

Yuan

Zhang

Lin

et al. 2017

Molecular Medicine Reports

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Multidrug resistance (MDR) is a major clinical obstacle in the successful treatment of patients with metastatic nasopharyngeal carcinoma (NPC). Results from previous studies suggest that microRNAs (miRNA) may be involved in promoting MDR in multiple cancer types. However, the role of miR‑125b in modulating the MDR of NPC is elusive. In the present study, miR‑125b expression in cisplatin (DDP) ‑resistant CNE2 cells (CNE2/DDP) was compared with parental counterparts, using reverse transcription‑quantitative polymerase chain reaction. A >3‑fold reduction in miR‑125b expression levels was observed in CNE2/DDP cells compared with parental CNE2 cells. Ectopic expression of miR‑125b by transfecting CNE2/DDP cells with miR-125b mimics, increased DDP‑induced cytotoxicity, apoptosis and chemosensitivity. By contrast, suppression of miR-125b by transfecting CNE2 cells with miR‑125b inhibitors, reduced DDP‑induced cytotoxicity and apoptosis, and facilitated cisplatin resistance. The results suggest that miR‑125b may regulate the sensitivity of NPC cells to DDP by modulating the expression levels of antiapoptotic factor B-cell CLL/lymphoma 2. Collectively, the results of the present study highlight miR‑125b as a potential therapeutic target for reversing MDR in NPC.

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“…Liver metastasis seems to be an independent negative prognostic factor versus bone or lung metastasis, whereas lung metastasis alone appeared to be a relatively favorable prognostic factor [ 12 – 14 ]. Single metastatic lesion in isolated location (organ or site) was reported to associate with prolonged survival versus multiple metastatic lesions in isolated or multiple locations [ 14 – 16 ]. Moreover, a growing body of evidence showed that long-term survival could be achieved for selective NPC patients with limited metastatic lesions by a combination of systemic and local therapies [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system

et al. 2015

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IntroductionThe current metastatic category (M) of nasopharyngeal carcinoma (NPC) is a “catch-all” classification, covering a heterogeneous group of tumors ranging from potentially curable to incurable. The aim of this study was to design an M categorization system that could be applied in planning the treatment of NPC with synchronous metastasis.MethodsA total of 505 NPC patients diagnosed with synchronous metastasis at Sun Yat-sen University Cancer Center between 2000 and 2009 were involved. The associations of clinical variables, metastatic features, and a proposed M categorization system with overall survival (OS) were determined by using Cox regression model.ResultsMultivariate analysis showed that Union for International Cancer Control (UICC) N category (N1–3/N0), number of metastatic lesions (multiple/single), liver involvement (yes/no), radiotherapy to primary tumor (yes/no), and cycles of chemotherapy (>4/≤4) were independent prognostic factors for OS. We defined the following subcategories based on liver involvement and the number of metastatic lesions: M1a, single lesion confined to an isolated organ or location except the liver; M1b, single lesion in the liver and/or multiple lesions in any organs or locations except the liver; and M1c, multiple lesions in the liver. Of the 505 cases, 74 (14.7%) were classified as M1a, 296 (58.6%) as M1b, 134 (26.5%) as M1c, and 1 was not specified. The three M1 subcategories showed significant difference in OS [M1b vs. M1a, hazard ratio (HR) = 1.69, 95% confidence interval (CI) = 1.16–2.48, P = 0.007; M1c vs. M1a, HR = 2.64, 95% CI = 1.75–3.98, P < 0.001].ConclusionsWe developed an M categorization system based on the independent factors related to the prognosis of patients with metastatic NPC. This system may be helpful to further optimize individualized care for NPC patients.

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Prognostic Factors on Overall Survival of Newly Diagnosed Metastatic Nasopharyngeal Carcinoma

Cited by 20 publications

References 19 publications

The Ratio of C-Reactive Protein/Albumin is a Novel Inflammatory Predictor of Overall Survival in Cisplatin-Based Treated Patients with Metastatic Nasopharyngeal Carcinoma

The Ratio of C-Reactive Protein/Albumin is a Novel Inflammatory Predictor of Overall Survival in Cisplatin-Based Treated Patients with Metastatic Nasopharyngeal Carcinoma

microRNA-125b reverses the multidrug resistance of nasopharyngeal carcinoma cells via targeting of Bcl-2

Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system

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