Prognostic Factors on Low-Birth-Weight Infants of Atresia and/or Tracheoesophageal Fistula: a Cohort Study

Abstract

Background: Low-birth-weight is the main factor affecting the survival rate of esophageal atresia (EA)/ tracheoesophageal fistula (TEF). The study aims to summarize the factors influencing the prognosis of EA/TEF, which is expected to be helpful for clinical diagnosis and treatment. Methods: A retrospective data analysis was performed in our hospital underwent TEF/EA repair between January 2012 and January 2015. The incidence of preoperative, intraoperative critical events and postoperative complications and overall survival (OS) were compared between two groups of infants: 81 patients with EA/TEF, 24 low-birth-weight patients (<2500 g) with EA/TEF and 57 patients (>2500 g). The morbidity was compared between patients with stress hyperglycemia and euglycemia postoperatively. Results: The overall incidence of preoperative, intraoperative critical events and postoperative complications in low-birth-weight patients was significantly higher (P=0.002, P=0.001, P=0.001), but OS was lower (75.9% vs 92.3%, p=0.027). OS of patients with stress hyperglycemia postoperatively was lower than that of euglycemia (81.0% vs 93.6%, p=0.03).Conclusions: Low-birth-weight still was the main factor that impacted on the prognosis of EA/TEF. The lower the birth weight was, the higher the mortality was. Postoperative stress hyperglycemia was one of the important factors that influenced survival rate.

Prevalence of esophageal atresia as well as Mortality Outcomes based on Prognostic Criteria at Tarakan General Hospital from 2015 To 2021

“…Research in China in 2020 entitled Prognostic Factors on Low-Birth-Weight Infants of Atresia and / or Tracheoesophageal Fistula: a Cohort Study, with a study sample of 81 patients, found that the overall prevalence of preoperative, intraoperative, and postoperative complications was significantly higher in lowbirth-weight patients (P = 0.002, P = 0.001, P = 0.001), but OS was lower (75.9 percent vs 92.3 percent, p = 0.027). The postoperative OS of patients with stress hyperglycemia was lower than that of patients with euglycemia (81.0 percent vs 93.6 percent, p = 0.03) [28] . Another study in India in 2008, entitled Esophageal atresia: Factors influencing survival -Experience at an Indian tertiary center with a total sample size of 127 samples collected from February 2004 to May 2006, explained that In 117 cases, EA with TEF was the most common type (92 percent ).…”