Prognostic Factors of Oral Squamous Cell Carcinoma in Young Patients: A Systematic Review

Morais, Everton Freitas de; Mafra, Rodrigo Porpino; Gonzaga, Amanda Katarinny Goes; Souza, Dyego Leandro Bezerra de; Pinto, Leão Pereira; Silveira, Éricka Janine Dantas da

doi:10.1016/j.joms.2016.12.017

Cited by 41 publications

(41 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prognostic factors for tongue SCC have been widely evaluated; accepted predictors include high tumor stage, neck node metastasis, adverse pathologic characteristics, and high NLR value . Nevertheless, the significance of LLN metastasis has never been evaluated.…”

Section: Discussionmentioning

confidence: 99%

Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue

Fang

et al. 2019

The Laryngoscope

View full text Add to dashboard Cite

Objectives: To investigate the role of lingual lymph node (LLN) metastasis on locoregional control (LRC) in patients with locally advanced tongue squamous cell carcinoma (SCC).Methods: A total of 231 patients were prospectively enrolled. Analyses focused on the association between the LLN metastasis and clinical pathologic variables as well as the significance of LLN metastasis in predicting prognosis.Results: LLNs were noted in 58 patients, 33 of whom were positive for LLN metastasis. LLN metastasis was significantly related to adverse pathologic characteristics. In patients with LLN metastasis, the 5-year LRC rate was 45%. In patients without LLN metastasis, the 5-year LRC rate was 65% and the difference was significant (P = 0.013). Further, Cox model analysis confirmed the independence of LLN metastasis from prognosis prediction.Conclusion: LLN metastasis in locally advanced tongue SCC is relatively uncommon; however, LLNs should be routinely dissected because they could significantly decrease locoregional control.

show abstract

Section: Discussionmentioning

confidence: 99%

Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue

Fang

et al. 2019

The Laryngoscope

View full text Add to dashboard Cite

show abstract

“…The influence of age and gender on the prognosis of OSCC patients has been investigated in some recent studies, but the results were generally controversial, which reflect variations in a large number of factors, such as the time span allowed for the collection of cases, samples size, prevalence of risk factors, time elapsed since diagnosis, access to healthcare services, geographic location, and global trends in OSCC. Some of the studies claimed that prognosis at a young age was similar (Blanchard et al, ; de Morais et al, ; Farquhar et al, ; Martinez et al, ), worse (Zhang et al, ), or better (Sommers et al, ) compared to that of older patients. We found that male gender was associated with a poorer prognosis, which was in accordance with previous studies (Ong, Murphy, Smith, Kanatas, & Mitchell, ; Santos et al, ).…”

Section: Discussionmentioning

confidence: 99%

Oral cancer‐associated fibroblasts predict poor survival: Systematic review and meta‐analysis

et al. 2019

View full text Add to dashboard Cite

Objectives To perform systematic review and meta‐analysis on correlations between cancer‐associated fibroblasts (CAFs) and the risk of death for patients with oral squamous cell carcinoma. Subjects and methods English literature (1966–2018) was systematically analyzed for studies that immunohistochemically assessed CAF density by alpha‐smooth muscle actin and presented 5 year survival rates by Kaplan–Meier plots. Mean age of patients, proportion of male/female patients, and male/female majority (>50% male/female patients) per study were also collected. Significance level for statistical models was p < 0.05. Results Meta‐analysis comprised 11 studies/1,040 patients. Univariate Cox regressions showed that high CAF density was a negative prognostic factor in studies with female and male majority [OR 5.329 (95% CI 3.223–8.811), p < 0.001, and OR 2.208 (95% CI 1.717–2.839), p < 0.001, respectively]. High CAF density with male majority was associated with a more favorable prognosis [OR 0.996 (95% CI 0.979–1.013), p < 0.001]. Multivariate Cox regressions showed that death risk was significantly higher among patients with high CAF density compared to low CAF [OR 2.741 (95% CI 2.220–3.384) p < 0.001]. High mean age and male proportion were significantly protective [OR 0.940 (95% CI 0.925–9.955), p < 0.001, OR 0.125 (95% CI 0.018–0.867), p = 0.035), respectively]. Conclusions CAFs increased death risk, male majority, and higher mean age were protective. A clinically validated cutoff for CAF density could serve as a reliable prognostic tool.

show abstract

“…Early reports suggested that early onset OTC was not associated with classical head and neck cancer risk factors such as alcohol and tobacco use and was associated with a worse prognosis than typical onset OTC . Yet, several recent studies identified alcohol and tobacco use as the main risk factors for early onset OTC and found no difference in survival between early and typical onset OTC, including in a systematic review of 11 OTC studies by de Morais . Given the limitations of prior studies and the increasing incidence of OTC, larger studies with more detailed clinical information on patient prognosis as well as the traditional head and neck cancer risk factors are needed.…”

Section: Introductionmentioning

confidence: 99%

Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes

et al. 2019

View full text Add to dashboard Cite

Background Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. Methods A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Results Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2‐6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8‐15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2‐0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). Conclusions This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.

show abstract

Prognostic Factors of Oral Squamous Cell Carcinoma in Young Patients: A Systematic Review

Cited by 41 publications

References 38 publications

Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue

Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue

Oral cancer‐associated fibroblasts predict poor survival: Systematic review and meta‐analysis

Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes

Contact Info

Product

Resources

About