Prognostic factors of long-term functioning and productivity after traumatic brain injury: a systematic review of prospective cohort studies

Son, Agnes H P Willemse-van; Ribbers, Gerard M.; Verhagen, Arianne P.; Stam, Henk J.

doi:10.1177/0269215507077603

Cited by 126 publications

(94 citation statements)

References 49 publications

(58 reference statements)

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“…Ten studies identified either single or multiple cognitive variables as predictors of RTW post TBI, including 4 Level I studies [22,25,33,34], one Level II study [23], 2 Level III studies [21,26], and 3 Level IV studies [24,35,36]. Executive functioning emerged as the most commonly cited predictor variable of RTW post TBI and was cited in three studies [23,34,35].…”

Section: Cognitive Variables Predict Return To Work Post Traumatic Brmentioning

confidence: 99%

“…variable in two studies [24,37]. Attention [24,35], memory [23,33], and verbal skills [22,23] were also cited in two studies each as predictors of RTW post-TBI. Other cognitive factors cited in the studies included: performance IQ [22]; the Functional Independence Measure (FIM™) outcome, which also assesses cognitive disability [21]; global cognitive functioning [34]; perceptual ability [34]; and processing speed [35].…”

Section: Watt and Penn (2000)mentioning

confidence: 99%

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Cognition and return to work after mild/moderate traumatic brain injury: A systematic review

Mani¹,

Cater

Hudlikar

2017

WOR

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Abstract. BACKGROUND:Approximately two percent of the United States population are traumatic brain injury (TBI) survivors. The unemployment rate among them is substantial. Cognitive skills are essential to perform any job. OBJECTIVE: We analyzed the literature on cognitive rehabilitation (CR) related to mild/moderate TBI to learn the influence of cognition on return to work (RTW) post TBI. METHODS:We conducted a systematic review of the studies on CR related to RTW post TBI that were published between 2000 and 2015. RESULTS: We critically reviewed 30 studies that met the inclusion criteria. Ten studies highlighted cognition as a predictor variable, seven studies demonstrated support for cognitive testing in RTW assessments, and 13 studies showed the efficacy of CR in facilitating RTW post TBI. CONCLUSION: Cognition plays a significant role in predicting and facilitating RTW in patients with TBI.

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Section: Cognitive Variables Predict Return To Work Post Traumatic Brmentioning

confidence: 99%

Section: Watt and Penn (2000)mentioning

confidence: 99%

Cognition and return to work after mild/moderate traumatic brain injury: A systematic review

Mani¹,

Cater

Hudlikar

2017

WOR

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“…In this period, the value of the Glasgow Coma Scale in critical patients could change very quickly, coupled with inexperienced health care workers assessing patients with neurological disorders in pre-admission care [16]. Age is a well-known factor for unfavourable outcome in patients suffering TBI [2,3,17]. Nevertheless, serum ionized calcium in our study was an independent finding regarding age.…”

Section: Discussionmentioning

confidence: 66%

“…This finally leads to neuronal loss manifested in disability and even death, as shown in Figures 1 and 2. [1,2,26].…”

Section: Discussionmentioning

confidence: 99%

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Hypocalcaemia as a Prognostic Factor of Mortality and Morbidity in Moderate and severe Traumatic Brain Injury and its role with Protein S-100b

Luna-Muñoz¹

2017

Journal of Neurological Disorders

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IntroductionThe effects of traumatic brain injury (TBI) can result in severe disability or death [1,2] and have an important social and economic impact [1]. The annual direct and indirect costs of TBI amount to roughly 2.5 billion euros [1,3]. MRI performed within the first 8 days after head injury was found to be a reliable predictor of death and moderate/severe disability for patients in coma and on ventilation following TBI, depending on the location of the lesion [4]. Apart from imaging signs, other easy-to-assess early predictors of outcome are lacking. As such, there is an on-going effort to identify biological markers that are closely related to clinical symptoms in order to better predict the outcome after TBI.The recent adoption of high throughput technologies and a change in focus from the identification of single to multiple markers has fostered new optimism in this direction [5][6][7]. Different markers have been studied, particularly bivalent cations such as magnesium (Mg 2+ ) and calcium (Ca 2+ ) [5][6][7]. Of these, calcium seems to play a more important role in TBI [5,8]. A study performed in 2010 compared statins (cholesterol-lowering drugs) as inductors of an anti-inflammatory effect, promoting recovery after moderate/severe TBI. The results showed that patients with a lower serum calcium level on day 3 died earlier than those patients who had a normal serum calcium level on day 3 after TBI. This led to the development of an ambispective study including a total of 122 Mexican patients suffering from moderate/ severe TBI, which showed that hypocalcaemia on day 3 seemed to be a reliable predictor of mortality after TBI, reaching significant levels (P=0.026) [6]. However, morbidity was not assessed. Our objective was to evaluate whether hypocalcaemia of serum ionized calcium (defined as <1.10 mmol/L (4.5 mg/dL) is a prognostic factor for mortality and morbidity (defined as GOS ≤ 3) in early moderate and severe TBI. AbstractIntroduction: The effects of traumatic brain injury (TBI) can result in severe disability or death and have an important social and economic impact. Its annual direct and indirect costs amount to roughly 2.5 billion euros. Our objective was to evaluate whether hypocalcaemia of serum ionized calcium (defined as <1.10 mmol/L (4.5 mg/dL) is a prognostic factor for mortality and morbidity (defined as GOS ≤ 3) in early moderate and severe TBI.

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Cranial Trauma in Adults

Hutchinson

2009

Practical Handbook of Neurosurgery

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Prognostic factors of long-term functioning and productivity after traumatic brain injury: a systematic review of prospective cohort studies

Cited by 126 publications

References 49 publications

Cognition and return to work after mild/moderate traumatic brain injury: A systematic review

Cognition and return to work after mild/moderate traumatic brain injury: A systematic review

Hypocalcaemia as a Prognostic Factor of Mortality and Morbidity in Moderate and severe Traumatic Brain Injury and its role with Protein S-100b

Cranial Trauma in Adults

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