Prognostic factors of asthma severity: A 9-year international prospective cohort study

Marco, Roberto de; Marcon, Alessandro; Jarvis, Déborah; Accordini, Simone; Almar, Enrique; Bugiani, Massimiliano; Carolei, Adriana; Cazzoletti, Lucia; Corsico, Angelo Guido; Gíslason, Davíð; Gulsvik, Amund; Jõgi, Rain; Marinoni, Alessandra; Martínez-Moratalla, Jesús; Pin, Isabelle; Janson, Christer

doi:10.1016/j.jaci.2006.03.019

Cited by 181 publications

(152 citation statements)

References 48 publications

(39 reference statements)

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…In a study involving adult patients with asthma in Europe, IgE was found to be a strong predictor of moderate-to-severe asthma. (22) In another study, higher total IgE levels were shown to be associated with the degree of asthma severity among younger subjects with difficult-to-treat or severe asthma. (23) Recently, other authors have reported that, among patients with asthma, mean FEV 1 is significantly lower in those with high IgE levels than in those with low IgE levels.…”

Section: Resultsmentioning

confidence: 94%

Serum total IgE levels and total eosinophil counts: relationship with treatment response in patients with acute asthma

Razi

Moosavi

2010

J. bras. pneumol.

View full text Add to dashboard Cite

Objective: To determine whether serum total IgE levels and total eosinophil counts have any relationship with the response to routine pharmacological treatment in patients with acute asthma. Methods: A cross-sectional study involving 162 patients with acute asthma. Serum total IgE levels, peripheral blood cell counts and eosinophil counts were determined. The treatment was adjusted for each patient according to the severity of asthma. Spirometry was performed at baseline and two weeks after the treatment. The patients were divided into two groups: high IgE (≥100 IU/mL) and low IgE (<100 IU/mL). We compared the two groups in terms of the relationships between baseline values and final values (percentage change) for the following parameters: FEV 1 , FVC, FEF 25-75% , peripheral white blood cell counts and eosinophil counts. Results: There were no significant differences between the groups regarding the percentage changes of the studied parameters. Nor were there significant differences between the groups regarding FEV 1 , FVC, and FEF 25-75% (% of the predicted values) at baseline. Conclusions: On the basis of these findings, we conclude that serum total IgE levels, peripheral white blood cell counts and eosinophil counts cannot predict the response to the pharmacological treatment of patients with acute asthma.Keywords: Asthma/drug therapy; Eosinophils; Immunoglobulin E Resumo Objetivo: Determinar se há uma relação dos níveis de IgE total no soro e das contagens de eosinófilos com a resposta à farmacoterapia de rotina em pacientes com asma aguda. Métodos: Estudo transversal com 162 pacientes com asma aguda. Foram determinados os níveis séricos de IgE total, as contagens de células no sangue periférico e as contagens de eosinófilos. O tratamento foi ajustado individualmente de acordo com a gravidade da asma. Foi realizada espirometria antes do início do tratamento e duas semanas após seu término. Os pacientes foram divididos em dois grupos: alto nível de IgE (≥ 100 UI/mL) e baixo nível de IgE (< 100 UI/mL). Foram comparadas entre os dois grupos as relações das determinações basais e das alterações em percentual dos seguintes parâmetros: VEF, CVF, FEF 25-75% , contagem de células brancas no sangue periférico e contagem de eosinófilos. Resultados: Não houve diferenças significativas entre os grupos em relação às alterações em percentual dos parâ-metros estudados. Tampouco houve diferenças significativas entre os grupos em relação aos valores basais de VEF, CVF e FEF 25-75% , em % do predito. Conclusões: Com base nesses achados, concluímos que os níveis séricos de IgE total, as contagens de células brancas no sangue periférico e as contagens de eosinófilos não são preditores do tratamento farmacológico de pacientes com asma aguda.

show abstract

Section: Resultsmentioning

confidence: 94%

Serum total IgE levels and total eosinophil counts: relationship with treatment response in patients with acute asthma

Razi

Moosavi

2010

J. bras. pneumol.

View full text Add to dashboard Cite

show abstract

“…There were significant differences between the controls and patients with asthma for total serum IgE levels and the percentage of peripheral blood eosinophils, which are two characteristics closely associated with asthma [8,9]. Compared with patients in the stable group, those in the exacerbation group had more severely compromised lung function ( In patients with asthma, the correlation between serum YKL-40 levels, total serum IgE levels, the percentage of peripheral blood eosinophils and the ratio of prebronchodilator FEV1 to the predicted value were investigated.…”

Section: Resultsmentioning

confidence: 95%

YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E

Tang

Zheng²,

Sun³

et al. 2010

European Respiratory Journal

View full text Add to dashboard Cite

The chitinase-like protein YKL-40, which binds chitin but lacks chitinase activity, has been found to be either the cause or a biomarker for asthma. The aim of our study was to investigate whether serum YKL-40 levels are increased in Chinese patients with asthma and identify its correlation to acute exacerbation, total serum immunoglobulin (Ig)E, the percentage of peripheral blood eosinophils and lung function. We quantified serum YKL-40 levels, total IgE levels and peripheral blood eosinophil percentages in patients with asthma, as well as in controls from the communities surrounding our hospital. The lung function of asthma subjects was also measured. Our data showed that the serum YKL-40 levels were significantly elevated in patients with asthma compared with controls and, when the asthma subjects were stratified, serum YKL-40 levels in the exacerbation group were higher than those in the stable and control groups. In addition, serum YKL-40 levels correlated positively with total serum IgE levels and the percentage of peripheral blood eosinophils, but correlated inversely with lung functions. Thus, we conclude that YKL-40 is found in increased quantities in the serum of Chinese patients with asthma, and its level correlates with exacerbation attacks, indicating that high levels of serum YKL-40 may be a biological characteristic of the exacerbation of asthma.

show abstract

“…Participants were classified as ''current asthma'' at follow-up (n51210), using previous definitions [10,18], if they had reported doctor-diagnosed asthma and if, in the past 12 months, they had reported respiratory symptoms (wheezing, nocturnal chest tightness, attack of breathlessness following activity, at rest or at night time, or at least one asthma attack) or had used asthma medications in ECRHS II. As previously described by CAZZOLETTI et al [10], participants with current asthma were classified as: 1) controlled asthma if all the following features were present: diurnal symptoms less than once a week, no nocturnal symptoms, no asthma attacks, short-acting b 2 -agonists twice or less per week in the past 3 months, no activity (work or other activities) limitations and no use of oral steroids in the past 12 months and FEV1 o80% pred; 2) partly controlled asthma if one or two of the above features of control were absent; 3) uncontrolled asthma if asthma, shortness of breath or wheezing had caused hospital/ emergency admissions in the past 12 months, oral corticosteroids were used on short courses or continuously in the past 12 months, the subject had .12 asthma attacks (more than one a week) in the past 3 months, or more than three of the controlled asthma features listed above were absent (see online supplementary material).…”

Section: Asthmamentioning

confidence: 99%

Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Moual¹,

Carsin²,

Siroux³

et al. 2013

European Respiratory Journal

View full text Add to dashboard Cite

Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS).Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect.Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0-2.40) and 1.7 (1.2-2.5), respectively); high (1.7 (1.0-2.8) and 1.9 (1.3-2.9), respectively) and low (1.6 (1.0-2.7) and 1.8 (1.2-2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1-3.6) and 2.3 (1.4-3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma.These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma. @ERSpublications Occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma in ECRHS II

show abstract

Prognostic factors of asthma severity: A 9-year international prospective cohort study

Cited by 181 publications

References 48 publications

Serum total IgE levels and total eosinophil counts: relationship with treatment response in patients with acute asthma

Serum total IgE levels and total eosinophil counts: relationship with treatment response in patients with acute asthma

YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E

Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Contact Info

Product

Resources

About