Prognostic Factors Influencing Contralateral Neck Lymph Node Metastases in Oral and Oropharyngeal Carcinoma

Capote-Moreno, Ana; Naval, Luís; Muñoz-Guerra, M.F.; Sastre, Jesús; Rodríguez-Campo, F.J.

doi:10.1016/j.joms.2009.09.071

Cited by 64 publications

(84 citation statements)

References 38 publications

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“…It is widely known that the lymph node metastases is an important prognosticator predicting survival of patients with OSCCs (36)(37)(38). Despite accumulating evidences pointing to the regulatory role of microRNAs in cancer progression and invasion, its regulatory role in oral cancer metastasis is still poorly understood.…”

Section: Discussionmentioning

confidence: 99%

miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

et al. 2014

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MicroRNAs offer tools to identify and treat invasive cancers. Using highly invasive isogenic oral squamous cell carcinoma (OSCC) cells, established using in vitro and in vivo selection protocols from poorly invasive parental cell populations, we used microarray expression analysis to identify a relative and specific decrease in miR-491-5p in invasive cells. Lower expression of miR-491-5p correlated with poor overall survival of patients with OSCCs. miR-491-5p overexpression in invasive OSCC cells suppressed their migratory behavior in vitro and lung metastatic behavior in vivo. We defined the G-protein-coupled receptor kinase-interacting protein 1 (GIT1)-as a direct target gene for miR-491-5p control. GIT1 overexpression was sufficient to rescue miR-491-5p-mediated inhibition of migration/invasion and lung metastasis. Conversely, GIT1 silencing phenocopied the ability of miR-491-5p to inhibit migration/invasion and metastasis of OSCC cells. Mechanistic investigations indicated that miR-491-5p overexpression or GIT1 attenuation reduced focal adhesions, with a concurrent decrease in steady-state levels of paxillin, phospho-paxillin, phospho-FAK, EGF/EGFR-mediated extracellular signal-regulated kinase (ERK1/2) activation, and MMP2/9 levels and activities. In clinical specimens of OSCCs, GIT1 levels were elevated relative to paired normal tissues and were correlated with lymph node metastasis, with expression levels of miR-491-5p and GIT1 correlated inversely in OSCCs, where they informed tumor grade. Together, our findings identify a functional axis for OSCC invasion that suggests miR-491-5p and GIT1 as biomarkers for prognosis in this cancer. Cancer Res; 74(3); 751-64. Ó2013 AACR.

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Section: Discussionmentioning

confidence: 99%

miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

et al. 2014

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“…The status of the regional lymphatics is one of the most important prognostic indicators in patients with head and neck cancer 5,6,7,8 . Treatment of the neck in patients with clinical evidence of nodal metastasis has traditionally been surgical, that is systematic removal of all the lymphatic tissues called as radical neck dissection (RND) described by Crile and later popularized by Martin 9,10,11 .Dissemination of metastatic cancer to regional lymph nodes from primary sites in the upper aerodigestive tract occurs in a predictable and sequential fashion.…”

Section: Discussionmentioning

confidence: 99%

“…Contralateral spread of metastases can occur in head & neck by three ways: 1) via crossing afferent lymphatic vessels; 2) by actual spread over midline via efferent lymphatic vessel after regional nodes become extensively involved and contralateral lymphatics flow takes place; 3) certain anatomical area where there is no definite midline 2,5 . Primary lesions at the rd of tongue.…”

Section: Discussionmentioning

confidence: 99%

“…The management of cancer with bilateral lymph node metastasis to the neck remains controversial 17 . Prediction of contralateral metastases may be useful in planning more aggressive therapies in patients with head and neck SCC with poor prognosis 5,6 . Morbidity with two stage bilateral procedure is worthy of consideration as apprehension exists regarding safety of simultaneous bilateral neck dissection.…”

Section: Discussionmentioning

confidence: 99%

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Simultaneous Bilateral Neck Dissection

Veeresh¹

2013

IOSR-JDMS

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“…As the carcinoma of the tongue, the floor of the mouth carcinoma is one of the more aggressive and more likely to spread at distant locations 15 . Capote-Moreno et al 14 reported that the incidence of contralateral local nodal metastasis is 11%. According to ACS 4 , the relative survival rate at 5 years with local metastasis is 75%, 38% with regional, and 20% with distance metastasis.…”

Section: Cancer Of the Floor Of The Mouthmentioning

confidence: 99%

Survival and mortality from oral cancer by anatomical location. A narrative review.

Candia¹,

Fernández²,

Kraemer³

2016

J Oral Res

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Prognostic Factors Influencing Contralateral Neck Lymph Node Metastases in Oral and Oropharyngeal Carcinoma

Cited by 64 publications

References 38 publications

miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

Simultaneous Bilateral Neck Dissection

Survival and mortality from oral cancer by anatomical location. A narrative review.

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