Prognostic factors in the surgical treatment of patients with oral carcinoma

Abstract

The aim of the study was to analyse the clinical outcome of patients treated surgically for oral carcinoma. A retrospective cohort study was undertaken of 356 patients with oral cavity cancer whose clinicopathological information had been collected prospectively onto a dedicated head and neck database. Disease recurrence and survival were assessed. Neck metastases occurred in 42% of patients. Tumour thickness (both 2 and 5 mm) predicted the presence of nodal metastases. Both pathological T stage (P < 0.001) and tumour thickness cut-off of 5 mm (P = 0.03) were independent predictors of disease-specific survival. With a median follow up of 41 months, overall survival at 5 years was 59% and disease-specific survival was 73%. Patients with thick tumours have a high risk of nodal metastases and this supports the liberal use of elective selective neck dissection in patients with clinically negative necks.

Peroxisome proliferator-activated receptor-γ in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival

“…The detection of occult metastasis remains difficult, so that the establishment and validation of prognostic markers in primary tumor specimens has been considered of high priority (Kantola et al 2000;Wangsa et al 2008). Substantial evidence has suggested that clinicopathological parameters in mobile tongue SCC provide crucial clinical information regarding disease prognosis and further adjuvant therapeutic approaches (Po Wing Yen et al 2002;Patel et al 2009). Tongue carcinoma has been shown to present high local failure and poor survival rates compared to other anatomic sites of the oral cavity (Shiboski et al 2005).…”

Oral and Oropharyngeal Squamous Cell Carcinoma in Our Population: The Clinic-Pathological and Morphological Description of 153 Cases

“…The prognosis of patients with these cancers depends upon a wide range of factors that may be grouped into patient-, tumour-and treatment-related (Massano et al, 2006). The tumour related factors include the size of tumour, site of tumour, thickness of tumour, degree of differentiation and spread into regional lymph nodes (González-García et al, 2009;Weijers et al, 2009;Patel et al, 2009;Rivera et al, 2008;Shaw et al, 2009). The present study is aimed at identifying the prevalence of tumour-related morphological and pathological factors such as the site, stage, degree of differentiation and lymph node involvement in oral and oropharyngeal squamous cell carcinomas in our population.…”

Role of Depth of Invasion in Evaluation and Management of Early-stage Oral Cavity Squamous Cell Carcinoma

“…However, tumor thickness itself appears to have independent prognostic implications. Patel et al 25 demonstrated on multivariate analysis that tumor thickness of 5 mm or greater was an independent predictor of disease-specific survival. Pinto et al 26 similarly described an independent disease-free survival advantage over 12 months for tumor thickness greater than 10 mm.…”