Prognostic factors in the operative treatment of ductal pancreatic carcinoma

Gebhardt, C; Meyer, W.; Reichel, Markus; Wünsch, Peter H.

doi:10.1007/s004230050004

Cited by 84 publications

(53 citation statements)

References 25 publications

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“…Tumors larger than 4.1 cm were all associated with lymph-vessel and perineural invasions. Therefore, our conclusion is that the larger the tumor the more extensive infiltration within interstitial invasion and nodal involvement, or the higher the recurrent risk, this is in accord with that reported in the literature [18][19][20][21] . In comparision with D1 -, D2 + procedure decreased recurrence in no and n1 group.…”

Section: Discussionsupporting

confidence: 90%

Risk factors influencing recurrence following resection of pancreatic head cancer

Mu¹,

Peng²,

Wang³

2004

WJG

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AIM:Whether operative procedure is a risk factor influencing recurrence following resection of carcinoma in the head of pancreas or not remains controversies. In this text we compared the recurrence rate of two operative procedure: the Whipple procedure and extended radical operation, and inquired into the factors influencing recurrence after radical resection. METHODS:From January 1995 to December 1998, 35 cases of carcinoma of pancreas underwent the Whipple operadure, 21 patients received the Extended radical operation. All patients were followed up for more than 3 years. Prognostic factors included operative procedure, size of tumor, lymph node, interstitial invasion. RESULTS:Deaths duo to recurrence within 3 years after operation were studied. The death rate was 51.4% in the Whipple procedure and 42.9% in the Extended radical operative procedure. There was a significant difference between the two groups. Recurrence occurred in 75% patients with tumor large than 4 cm, in 87.5% patients with lymph node involvement, and in 50% patients with the presence of interstitial invasion. CONCLUSION:Tumor exceeding 4 cm, lymph node involvement, and presence of interstitial invasion are high risk factors of recurrence after Whipple's procedure and extended radical operation.Mu DQ, Peng SY, Wang GF. Risk factors influencing recurrence following resection of pancreatic head cancer. World J Gastroenterol 2004; 10(6): 906-909

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Section: Discussionsupporting

confidence: 90%

Risk factors influencing recurrence following resection of pancreatic head cancer

Mu¹,

Peng²,

Wang³

2004

WJG

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“…RT is not implemented in metastatic patients except palliative treatment might have caused patient selection bias. The fact that the tumor grade is an important prognostic factor is shown in many studies [17][18][19]. However, no relationship is determined between the tumor grade and survival in our study.…”

Section: Discussioncontrasting

confidence: 64%

Clinicopathologic Prognostic Factors in Locally Advanced Pancreatic Cancer Patients Treated with Radiation Therapy

Kaya¹

2015

Ann Clin Anal Med

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Anahtar KelimelerPankreas Kanseri; Radyoterapi; Lenf Nodu Durumu; Tümör Çapı Abstract Aim: The prognosis of pancreatic cancer is one of the worst malignancies. In randomized clinical trials done in recent times, the answer is researched for adjuvant chemotherapy, chemoradiotherapy. Our study investigated the clinicopathologic prognostic factors for pancreatic cancer. Material and Method: Patients diagnosed with histopathologically confirmed pancreatic cancer, followed by Akdeniz University School of Medicine, Department of Radiation Oncology between the years 2000-2008 were included in the study. Results: A total number of 32 patients were taken to the study. The tumor diameter values in predicting survival were analyzed using ROC (Receiver Operating Characteristics) curve analysis. Patients were grouped according to their tumor diameters: the tumor diameter lower than 4 cm (Group A), the tumor diameter higher than 4 cm (Group B). The mean survival of patients is determined as 17.3 months. The fact that there is whether or not lymph node involvement is found to be related with survival (p=0.009). A significant relationship between Group A and B in terms of survival is determined (p=0.029). Conclusions: While treatment is considered in patients who are planned to receive radiation therapy because of pancreatic cancer, the tumor diameter and the lymph node status should be taken into account as prognostic factors.

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“…Rates of curative resection remain low and adjuvant therapy failure, even after curative resection, has only limited impact2, 3, 4, 5, 6. Neoadjuvant therapy has been advocated in an attempt to increase radical resections, decrease distant recurrence and improve selection of patients for surgery.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the impact of neoadjuvant therapy on patterns of recurrence in pancreatic ductal adenocarcinoma

et al. 2018

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BackgroundNeoadjuvant therapy may increase the rate of radical tumour resection in patients with pancreatic cancer. Its impact on tumour recurrence has not been investigated fully. This study aimed to assess the impact of neoadjuvant therapy on patterns of recurrence.MethodsA systematic review was performed of articles identified through the PubMed, Scopus, Embase, Ovid and Google Scholar databases that analysed the relationship between neoadjuvant therapy and recurrence published to January 2016. The main endpoint was overall tumour recurrence. Other endpoints included local recurrence, any kind of distant, hepatic, pulmonary or peritoneal metastasis.ResultsA total of 4257 citations were reviewed. Twelve observational studies comprising 1365 patients were analysed. Neoadjuvant therapy significantly reduced the risk of overall (risk ratio (RR) 0·82, 95 per cent c.i. 0·74 to 0·90; P < 0·001) and local (RR 0·42, 0·32 to 0·55; P < 0·001) recurrence. Neoadjuvant therapy did not reduce the risk of any kind of distant (RR 1·02, 0·91 to 1·14; P = 0·78), hepatic (RR 0·86, 0·68 to 1·10; P = 0·23), pulmonary (RR 0·99, 0·37 to 2·66; P = 0·98) or peritoneal (RR 0·88, 0·57 to 1·38; P = 0·58) metastasis.ConclusionNeoadjuvant therapy reduced the risk of local recurrence but not that of distant metastasis.

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Prognostic factors in the operative treatment of ductal pancreatic carcinoma

Cited by 84 publications

References 25 publications

Risk factors influencing recurrence following resection of pancreatic head cancer

Risk factors influencing recurrence following resection of pancreatic head cancer

Clinicopathologic Prognostic Factors in Locally Advanced Pancreatic Cancer Patients Treated with Radiation Therapy

Meta-analysis of the impact of neoadjuvant therapy on patterns of recurrence in pancreatic ductal adenocarcinoma

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