Prognostic Factors in T3,N0-1 Glottic and Transglottic Carcinoma: A Multifactorial Study of 221 Cases Treated by Surgery or Radiotherapy

Prognostic determinants in supraglottic carcinoma: Univariate and Cox regression analysis

“…Nevertheless, when all these variables were examined by multivariate analysis, only invasion of the thyroid cartilage and of the extralaryngeal soft tissues showed a significant impact on determinate survival, with an RR of death of 2.4 each ( Table 7). Another peculiar observation in our study, which seems to corroborate the data reported by Kowalski et al, 32 is that involvement of the medial wall of the pyriform sinus emerged as a significant predictor of outcome. Even though the value of this finding is hampered by the small number of patients exposed to the risk, a possible explanation could stem from treatment selection.…”

“…However, only a few authors have documented a significant relationship between parameters expressing the intra-and extralaryngeal extent of the primary lesion and survival. 7,13,24,32 In our study, 22 parameters related to the extent of the tumor were tested by univariate analysis ( Table 3). Some of them were significantly associated with survival (marginal versus vestibular tumor site, extralaryngeal invasion, aryepiglottic fold involvement, arytenoid involvement, ventricle involvement, thyroid cartilage invasion, extralaryngeal soft tissue invasion, oropharynx invasion), and others showed a trend (p < .2) toward such an association (false vocal cord involvement, true vocal cord involvement, preepiglottic space involvement, hypopharynx invasion, fixed vocal cord, involvement of the medial wall of the pyriform sinus).…”

“…46 The strong prognostic value of factors related to N status has been demonstrated by several multivariate analyses. 6,7,10,14,16,17,19,21,22,26,28,32,33 Although extracapsular spread has been unanimously found to have a significant impact on survival, 10,17,28,32,33 conflicting results have been obtained on the number of metastatic lymph nodes. 6,16,17,32,33 Similarly, the level of lymph node involvement was a significant predictor of outcome in a study by Moe et al, 33 whereas no prognostic relevance was reported for this variable by Kowalski et al 32 All the factors related to N status significantly affected survival in our univariate analysis, whereas only extracapsular spread was associated with a higher RR of death in the final multivariate model.…”

“…Degree of differentiation is the most extensively investigated histopathologic parameter, 6,7,10,12,14,17,19,22,26,27,29,30,32 but only a few studies have been able to document its impact on prognosis. 6,26,29 Even in our study, degree of differentiation was significantly correlated with survival in the univarate (Table 3) but was not related with an increased RR of death in the multivariate analysis.…”

Laryngeal Carcinoma Multivariate Analysis of Prognostic Factors in 1 252 Consecutive Patients Treated with Primary Radiotherapy

“…MacKenzie et al (18) and Marshak et al (19) showed a better local control with small tumors and Raitiola et al (20) a better rate of survival in 293 Finnish laryngeal patients. MacKenzie et al (18) documented N-stage as a prognostic factor for local control and Kowalski et al (14) for survival. Jacobsen et al (21) revealed the volume of lymph node metastases to be an independent, prognostic factor.…”