Prognostic factors in stage IV gastric cancer: univariate and multivariate analyses

Yagi, Yoshihiro; Seshimo, Akiyoshi; Kameoka, Shingo

doi:10.1007/pl00011699

Cited by 41 publications

(34 citation statements)

References 10 publications

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“…There are various statistical methods to investigate the effect of different factors on the survival of patients with gastric cancer. The identification of factors affecting the survival of patients with gastric cancer, however, is mostly done by standard models of survival (Yagi et al, 2000;Adachi et al, 2003;Buonadonna et al, 2003;Chau et al, 2004;Zeraati et al, 2005c;Dehkordi and Tabatabaee, 2007;Pourhoseingholi et al, 2007;Biglarian et al, 2009). These models generally focus on the effective factors on time to occurrence of the death event.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies on cancer take factors affecting time to the occurrence of death into account, but in many cases, events occur in patients during the study period which may affect the final results (Yagi et al, 2000;Adachi et al, 2003;Buonadonna et al, 2003;Chau et al, 2004;Zeraati et al, 2005c;Dehkordi and Tabatabaee, 2007;Pourhoseingholi et al, 2007;Biglarian et al, 2009). Disregarding these states or intermediate events and the time of their occurrence can influence the results of study and bias the data analysis (Kay, 1986;Andersen, 1988;Andersen and Keiding, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Survival Analysis of Patients with Gastric Cancer Undergoing Surgery at the Iran Cancer Institute: A Method Based on Multi-State Models

Zare

Mahmoodi²,

Mohammad³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Gastric cancer is one of the most common causes of cancer deaths all over the world and the most important reason for its high rate of death is its belated diagnosis at advanced stages of the disease. Events occur in patients which are regarded not only as themselves factors affecting patients' survival but also which can be affected by other factors. This study was designed and implemented aiming to identify these events and to investigate factors affecting their occurrence. Materials and Methods: Data from 330 patients with gastric cancer undergoing surgery at the Iran Cancer Institute from 1995-1999 were analyzed. The survival time of these patients was determined after surgery and the effects of various factors including demographic, diagnostic and clinical as well as medical, and post-surgical varuiables on the occurrence of death hazard without relapse, hazard of relapse, and death hazard with a relapse were assessed. Results: The median survival time for these patients was 16.3 months and the 5-year survival rate was 21.6%. Based on the results of multi-state model, age and distant metastases affected relapse whereas disease stage, type and extent of surgery, lymph nodes metastases, and number of renewed treatments affected death hazard without relapse. Moreover, age, type and extent of surgery, number of renewed treatments, and liver metastases were identified as factors affecting death hazard in patients with relapse. Conclusions: Most cancer studies pay heed to factors which have effect on death occurrence, but some events occur which should be taken into consideration to better describe the natural process of the disease and provide researchers with more accurate data.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Survival Analysis of Patients with Gastric Cancer Undergoing Surgery at the Iran Cancer Institute: A Method Based on Multi-State Models

Zare

Mahmoodi²,

Mohammad³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…5,[8][9][10] A radical gastrectomy is the treatment for gastric cancer that is most highly associated with cure. However, patients with stage IV gastric cancer often receive other palliative surgical or nonsurgical procedures owing to their advanced disease status.…”

Section: Commentmentioning

confidence: 99%

Proposal to Subclassify Stage IV Gastric Cancer Into IVA, IVB, and IVM

Ha²,

Noh³

et al. 2009

Arch Surg

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“…Several studies reported that non-curative resection may also have survival benefits in gastric cancer patients with distant metastasis [1][2][3]. Other studies, however, found that non-curative gastrectomy had no survival benefits, but only increased postoperative morbidity and prolonged hospital stay [4][5][6][7][8]. Thus, the optimal therapeutic strategy for patients with gastric cancer and synchronous distant metastases remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Role of Surgery in the Management for Gastric Cancer with Synchronous Distant Metastases

Ikeguchi

Miyatani

Takaya

et al. 2015

Indian J Surg Oncol

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Optimal treatment of patients with gastric cancer with synchronous distant metastases is palliative chemotherapy. However, occasionally gastrectomy should be selected due to control bleeding from tumors, perforation, or obstruction. The aim of this study is to evaluate the survival benefits of non-curative gastrectomy for patients with synchronous distant metastasis. Total 78 gastric cancer patients with synchronous distant metastasis treated in our hospital between 2003 and 2012 were enrolled in this study. Of these, 74 patients (95 %) received S1 based chemotherapy. During the treatment, 37 patients (47.4 %) underwent palliative gastrectomy because of bleeding from tumors (n=15), tumor perforation (n=6), and obstruction (n=16). Survival benefits were compared in resected and non-resected patients, retrospectively. The two groups were clinicopathologically similar. Palliative gastrectomy was performed safely (morbidity: 10.8 % and mortality: 0) in resection group. However, resection showed survival benefits only in 13 patients (16.7 %) with single metastasis and without peritoneal metastasis. Their 2-year survival rate was 40 % and their median survival was 19 months. Non-curative gastrectomy with precise surgical techniques followed careful postoperative nutrition management may improve survival only for patients with a single metastatic site, except for peritoneal dissemination.

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Prognostic factors in stage IV gastric cancer: univariate and multivariate analyses

Cited by 41 publications

References 10 publications

Survival Analysis of Patients with Gastric Cancer Undergoing Surgery at the Iran Cancer Institute: A Method Based on Multi-State Models

Survival Analysis of Patients with Gastric Cancer Undergoing Surgery at the Iran Cancer Institute: A Method Based on Multi-State Models

Proposal to Subclassify Stage IV Gastric Cancer Into IVA, IVB, and IVM

Role of Surgery in the Management for Gastric Cancer with Synchronous Distant Metastases

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