Prognostic factors in solitary fibrous tumors of the pleura

Schmid, Severin; Csanádi, Ágnes; Kaifi, Jussuf T.; Kübler, Markus; Haager, B; Kayser, Gian; Passlick, Bernward; Wiesemann, Sebastian

doi:10.1016/j.jss.2015.01.049

Cited by 16 publications

(27 citation statements)

References 23 publications

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“…Recent literature focused on predictive models to identify patients at higher risk of metastatic spread by using age, tumor size, mitotic activity [21] and tumor necrosis [12,22]. In this regard, preliminary data of our study [23] were used by Salas et al [12] to validate their model that found that age <60 years, visceral involvement and high mitotic count can identify patient classes with different risk levels for developing local recurrence and metastatic spread.…”

Section: Discussionmentioning

confidence: 86%

Radiotherapy in the treatment of extracranial hemangiopericytoma/solitary fibrous tumor: Study from the Rare Cancer Network

Krengli

Cena

Zilli

et al. 2020

Radiotherapy and Oncology

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Background and purpose: The role of radiotherapy (RT) in the treatment of hemangiopericytoma/solitary fibrous tumor (HPC/SFT) is still under debate. We aimed at investigating whether radiotherapy can improve the results in patients operated for extracranial HPC/SFT. Materials and methods: Data from patients with HPC/SFT, treated from 1982 to 2012, were retrospectively reviewed within the Rare Cancer Network framework. Actuarial local control (LC), disease-free survival (DFS), metastasis-free survival (MFS) and overall survival (OS) were calculated with Kaplan-Meyer method. Patient and tumor parameters were analyzed by univariate and multivariate analysis. Results: Of 114 HPC/SFT, 58 (50.9%) occurred in the extremities/superficial trunk and 56 (49.1%) in intrathoracic/retroperitoneum. Seventy-eight patients (68.4%) underwent surgery only (Sx), and 36 (31.6%) Sx and RT (Sx + RT). Median RT dose was 60 Gy (range 45-68.4 Gy) in 1.6-2.2 Gy fractions. In the extremities/superficial trunk group of patients, actuarial 5-year LC rates were 50.4% after Sx and 91.6% after Sx + RT (p < 0.0001) for LC, and 50.4% after Sx and 83.1% after Sx + RT (p = 0.008) for DFS. In the intrathoracic/retroperitoneum group of patients, actuarial 5-year rates were 89.3% after Sx and 77.8% after Sx + RT (p = 0.99) for LC, and 73.8% after Sx and 77.8% after Sx + RT (p = 0.93) for DFS. At multivariate analysis, the addition of RT resulted in better LC and DFS in the whole series. The advantage was confirmed for LC in the group of patients affected by extremity/superficial trunk tumors. Conclusion: Addition of RT to Sx could improve the prognosis, in terms of LC and DFS, essentially in patients with extremities/superficial trunk tumor locations. Ó 2019 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 144 (2020) 114-120 Extracranial hemangiopericytomas and solitary fibrous tumors (HPC/SFT) were formerly classified as two different tumor entities. They have been merged as solitary fibrous tumors in the 2013 World Health Organization (WHO) classification [1] and represent a spectrum of disease from benign to malignant and infiltrative tumors with potential for hematogenous dissemination [2]. The NAB2-STAT6 fusion transcript is identified in most SFTs whatever their localization in the body [3,4]. Because of this complexity and their rarity (1-2% of all soft-tissue tumors) [5], controversies remain about their optimal management. Surgery is the standard

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Section: Discussionmentioning

confidence: 86%

Radiotherapy in the treatment of extracranial hemangiopericytoma/solitary fibrous tumor: Study from the Rare Cancer Network

Krengli

Cena

Zilli

et al. 2020

Radiotherapy and Oncology

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“…No obstante, el comportamiento biológico de estos tumores es variable y algunos muestran comportamiento maligno. Demostrar la estirpe celular mediante el análisis inmunohistoquímico es esencial para el diagnóstico adecuado 12 . En el caso presentado, la inmunomarcación vimentina, CD34 y Bcl-2 positivos simultáneamente con S100 negativo 3 , afirmaron la presencia de TFS.…”

Section: Discussionunclassified

Hipoglicemia inducida por tumor fibroso solitario pulmonar: Síndrome de Doege-Potter

Soutelo¹,

Moldes²,

Martín³

et al. 2016

Rev. méd. Chile

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We report the case of a 75-year-old man who was admitted to the hospital with symptoms of severe hypoglycemia. He had a history of solitary fibrous tumor diagnosed by Pathology after its complete surgical resection eight years before. The laboratory examination reported hypoglycemia with inhibited Insulin secretion. A computed tomography of the thorax revealed a large solid heterogeneous mass in the left hemithorax. Solitary fibrous tumor is a rare neoplasm. The association of solitary fibrous tumor and paraneoplastic hypoglycemia is known as Doege-Potter syndrome and occurs in less than 5% of all solitary fibrous tumors.

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“…El TFSP maligno típicamente se presenta como neoplasias lobuladas de diámetro mayor de 10 cm, con zonas de hemorragia y necrosis, 3 la mayoría se origina en la pleura visceral (68-78%) y son pediculados (57-83%). 4,5 Al momento del diagnóstico se presentan síntomas en 50-72% de los pacientes, 5 siendo los más frecuentes dolor torácico (16-59%), disnea (14-40%) y tos (8-24%). 5,6 El estudio inicial es la radiografía posteroanterior de tórax (figura 2) y la tomografía computarizada de tórax es el estudio de elección 7 (figura 3).…”

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“…4,5 Al momento del diagnóstico se presentan síntomas en 50-72% de los pacientes, 5 siendo los más frecuentes dolor torácico (16-59%), disnea (14-40%) y tos (8-24%). 5,6 El estudio inicial es la radiografía posteroanterior de tórax (figura 2) y la tomografía computarizada de tórax es el estudio de elección 7 (figura 3). El tratamiento es la resección quirúrgica en bloque por la alta probabilidad de recurrencia, con márgenes de 1-2 cm.…”

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“…El tratamiento es la resección quirúrgica en bloque por la alta probabilidad de recurrencia, con márgenes de 1-2 cm. 5,8 Para los tumores malignos o recidivantes se recomienda terapia adyuvante con quimio-o radioterapia. 9 La tasa de recurrencia es de hasta 9%, principalmente en tumores malignos y sésiles, ocasionando la muerte por tumores NCT www.medigraphic.org.mx intratorácicos extensos irresecables y metástasis a distancia.…”

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Tumor fibroso solitario de la pleura: Factores asociados a comportamiento maligno y recidiva. Experiencia institucional

Ríos-Pascual

Vázquez-Minero

Garza-Jiménez

et al. 2019

NCT Neumología Y Cirugía De Tórax

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Este artículo puede ser consultado en versión completa en http://www.medigraphic.com/neumologia RESUMEN. Introducción: El tumor fibroso solitario de la pleura representa menos del 5% de los tumores pleurales primarios, de 12 a 32% pueden tener comportamiento maligno con recurrencia local y metástasis. El estudio diagnóstico de elección es la tomografía computarizada de tórax. La mayoría se origina en la pleura visceral y son pediculados. El tratamiento es la resección quirúrgica en bloque por la alta probabilidad de recurrencia, con márgenes de 1-2 cm, 9% de los casos presenta recidiva. Objetivos: Identificar factores relacionados a comportamiento maligno y recidiva. Material y métodos: Estudio observacional, descriptivo, retrospectivo y transversal. Se incluyó a todos los pacientes sometidos a resección de tumor fibroso solitario de la pleura del Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México, de enero 2008 a diciembre 2017. Resultados: Se incluyeron 26 pacientes, la frecuencia mayor fueron tumores pediculados dependientes de la pleura visceral, 92% manifestó síntomas, principalmente disnea. Dieciocho benignos y ocho malignos, de los cuales dos recidivaron. Se presentó muerte asociada al tumor en dos casos. Conclusiones: Los factores relacionados a comportamiento maligno fueron la presencia de síntomas generales (p = 0.013), pérdida de peso mayor de 10 kg en los últimos seis meses (p = 0.004) e invasión a estructuras adyacentes (p = 0.020). Los factores relacionados a recurrencia fueron la presencia > 4 mitosis/10 campos de alto poder (p = 0.018), pérdida de peso mayor de 10 kg en los últimos seis meses (p = 0.046), invasión a estructuras adyacentes (p = 0.030) y resección quirúrgica subóptima (p = 0.003). El tumor fibroso solitario de la pleura es un tumor de comportamiento biológico incierto, por lo que deberán investigarse factores asociados a malignidad y recurrencia. El tratamiento es la resección quirúrgica en bloque y en caso de presentarse criterios de malignidad o recidiva se requiere terapia adyuvante.Palabras clave: Tumor fibroso solitario de la pleura, neoplasias pleurales, malignidad, recidiva. Fibrous solitary tumor of the pleura: Factors associated with malignant behavior and relapse Institutional experienceABSTRACT. Introduction: The fibrous lone tumor of the pleura represents less than 5% of the primary pleural tumors, from 12 to 32% can have malignant behavior with local recurrence and metastasis. The diagnostic study of choice is the computed tomography of thorax. Most originate in the visceral pleura and are pediculated. The treatment is surgical resection en bloc due to the high probability of recurrence, with margins of 1-2 cm. 9% of cases have recurrence. Objectives: Identify factors related to malignant behavior and recurrence. Material and methods: Observational, descriptive, retrospective and transversal study. All patients undergoing resection of TFSP are included in the National Institute of Respiratory Diseases, from January 2008 to December ...

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Prognostic factors in solitary fibrous tumors of the pleura

Cited by 16 publications

References 23 publications

Radiotherapy in the treatment of extracranial hemangiopericytoma/solitary fibrous tumor: Study from the Rare Cancer Network

Radiotherapy in the treatment of extracranial hemangiopericytoma/solitary fibrous tumor: Study from the Rare Cancer Network

Hipoglicemia inducida por tumor fibroso solitario pulmonar: Síndrome de Doege-Potter

Tumor fibroso solitario de la pleura: Factores asociados a comportamiento maligno y recidiva. Experiencia institucional

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