Prognostic Factors in Skull Base Chordoma: A Systematic Literature Review and Meta-Analysis

Prognostic Implications of Gadolinium Enhancement of Skull Base Chordomas

“…Given prior literature reporting a correlation between chordoma subtype and prognosis, 20,22,24 pathologic subtypes were also documented for each patient. Of the 22 chordomas, 8 were chondroid, 1 was dedifferentiated, and 13 were conventional.…”

“…4 A variety of prognostic factors has been reported for skull base chordomas, including the degree of surgical resection, tumor size, preoperative Karnofsky Performance Status, type of adjuvant radiation therapy, prior surgical and radiation history, and tumor pathology. 7,[12][13][14][15][16][17][18][19][20][21][22][23] Three pathologic subtypes have been identified-conventional, chondroid, and dedifferentiated-with conventional chordomas the most common and dedifferentiated chordomas the least common and having the least favorable prognosis. 12,20,22,24 Other factors, such as age and sex, have demonstrated variable associations with outcome.…”

“…7,[12][13][14][15][16][17][18][19][20][21][22][23] Three pathologic subtypes have been identified-conventional, chondroid, and dedifferentiated-with conventional chordomas the most common and dedifferentiated chordomas the least common and having the least favorable prognosis. 12,20,22,24 Other factors, such as age and sex, have demonstrated variable associations with outcome. 14,18,[20][21][22][25][26][27][28][29] However, there is a paucity of research investigating the correlation between imaging features for skull base chordomas and prognosis, or the lack thereof.…”

“…12,20,22,24 Other factors, such as age and sex, have demonstrated variable associations with outcome. 14,18,[20][21][22][25][26][27][28][29] However, there is a paucity of research investigating the correlation between imaging features for skull base chordomas and prognosis, or the lack thereof.…”

Glomus Jugulare Tumor Presenting as Deep Vein Thrombosis

“…One extrinsic foramen lesion includes chordomas, which are very rare bone tumors arising from remnants of the embryologic notochord. [16] They are most commonly found in the sacrum (50-60%), followed by the clivus and spheno-occipital synchondrosis region (25-30%) which extend laterally to the JF, although it is very rare for a midline lesion to extend laterally to the level of the IJV. [16,17] Among the intrinsic foramen lesions, paragangliomas (GJT) are the most common and account for 15% of all skull base lesions.…”