Prognostic Factors in Relation to Racial Disparity in Advanced Colorectal Cancer Survival

Wallace, Kristin; Sterba, Katherine R.; Gore, Elena; Lewin, David; Ford, Marvella E.; Thomas, Melanie B.; Alberg, Anthony J.

doi:10.1016/j.clcc.2013.08.001

Cited by 21 publications

(23 citation statements)

References 52 publications

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“…Racial disparities in male cancers such as prostate (Mahal et al 2014;Siegel et al 2014b) and colorectal (Siegel et al 2014a;Wallace et al 2013) are well documented. However, less is known about differences in clinical characteristics in nH black and white males diagnosed with HNSCCs, or about whether such differences have changed over time.…”

Section: Introductionmentioning

confidence: 99%

Racial differences in head and neck squamous cell carcinomas among non-Hispanic black and white males identified through the National Cancer Database (1998–2012)

Peterson

Khosla

Chen

et al. 2016

J Cancer Res Clin Oncol

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Section: Introductionmentioning

confidence: 99%

Racial differences in head and neck squamous cell carcinomas among non-Hispanic black and white males identified through the National Cancer Database (1998–2012)

Peterson

Khosla

Chen

et al. 2016

J Cancer Res Clin Oncol

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“…Blacks are consistently diagnosed at a younger age and later stage of disease suggesting that differences in incidence and outcome could be related to a more aggressive phenotype among a subset of patients. In support of this idea, recent reports among those with invasive CRC have found that younger blacks, compared to younger whites have more aggressive histologic features at diagnosis and poorer CRC outcomes (15, 16, 22, 23). …”

Section: Discussionmentioning

confidence: 85%

“…The lack of a significant association in metachronous adenomas by race may be due to low statistical power, as there were few blacks undergoing follow-up exams in two (12, 13) of the three studies. Alternatively, because CRC is diagnosed at earlier ages and tends to be more aggressive in younger blacks compared to younger whites (15, 16), racial differences in recurrence at younger ages may be present in a subset of patients but the effect could be masked if all ages are combined in analysis. To disentangle the impact of race and age on risk of metachronous large bowel polyps, we pooled data from three large placebo-controlled adenoma chemoprevention trials.…”

Section: Introductionmentioning

confidence: 99%

The Association of Age and Race and the Risk of Large Bowel Polyps

Wallace

Burke

Ahnen

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Blacks have a higher incidence of colorectal cancer (CRC) and a younger age at diagnosis compared to Whites. Few studies have investigated racial differences in risk of metachronous adenomas and serrated polyps whether this risk differs by polyp characteristics or age of patient. Methods We analyzed data pooled from three placebo-controlled adenoma chemoprevention trials to explore racial differences in the risk of large bowel polyps in patients ≤50 and > 50 years of age. Using generalized linear regression, we estimated risk ratios (RR) and 95% confidence intervals (CI) as measures of the association between race and risk of one or more adenomas or serrated polyps after randomization. Results Among the 2605 subjects who completed at least one follow-up exam, blacks ≤50 years of age had a higher risk of any conventional adenoma (RR 1.70, 95% CI 0.99–2.92) and advanced neoplasms (RR 4.05, 95% CI 1.43–11.46) and a non-significantly lower risk of serrated polyps (RR 0.75 (95% CI 0.34–1.62) compared to whites. Among patients > 50 years there was no racial difference in risk of adenomas (RR 1.08, 95% CI 0.92–1.27) or advanced neoplasms (RR 1.05, 95% CI 0.71–1.56)). However, blacks had a significantly lower risk of serrated polyps (RR 0.65, 95% CI 0.49–0.87) than whites. Conclusions Our results demonstrate a higher risk of metachronous adenomas in blacks compared to whites at younger ages. Impact Our results suggest that the racial disparity in CRC incidence may be due to an excess of neoplasia in younger blacks.

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“…The median survival in patients without metastasis was 160 ± 15 months, with a confi dence interval CI months and the median was 102 ± 2 with median confi dence interval CI [81-123] months. The median survival in patients with liver metastasis was 28 ± 6 months with a confi dence interval CI months and the median was 21 ± 3 months with a median confi dence interval CI [15][16][17][18][19][20][21][22][23][24][25][26][27][28] months.…”

Section: Resultsmentioning

confidence: 99%

“…27 This is especially important for the multidisciplinary approach and therapeutic (surgical, chemotherapy and radiotherapy) behavior in patients with HMD that provides a better longterm prognosis. 28,29 Langenhoff et al reported a higher risk of recurrence in patients after radical resection of liver metastases due to colorectal carcinoma and analyze similar measures, necessary to monitor patients after radical treatment of HMD.…”

Section: Discussionmentioning

confidence: 99%

Distant Liver Metastases as a Major Factor Influencing Survival in Patients with Colorectal Cancer

et al. 2016

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Aim: To assess the eff ect of the factor 'hepatic metastatic disease' on long-term outcomes in patients with colorectal cancer. Materials and methods: We analysed retrospectively 200 randomly selected patients. Forty-two of them were excluded from the study for diff erent reasons so the study contingent was 158 patients over a period of 23 years. All were diagnosed and treated in the Lozenetz University Hospital, in the Department of General Surgery. 125 of the patients were diagnosed with colorectal cancer without distant metastases and 33 of the patients had liver metastases as a result of colorectal carcinoma. The statistical analysis was performed using SPSS 19 IMB, with a level of signifi cance of P < 0.05 at which the null hypothesis is rejected. We also used descriptive analysis, Kaplan-Meier estimator, Log-Rank Test and LifeTable statistics models. Results: The median survival for patients without metastases was 160 months, and the median was 102 months. The median survival for patients with liver metastases was 28 months and the median was 21 months. One-year survival for patients without metastases was 92% versus 69% in patients with liver metastases. Conclusion: Average, annual and median survivals are infl uenced statistically signifi cantly by the presence of liver metastases compared to overall survival and that of patients without metastatic colorectal cancer. Liver metastatic disease is a proven factor aff ecting long-term prognosis and survival in patients with colorectal cancer.

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Prognostic Factors in Relation to Racial Disparity in Advanced Colorectal Cancer Survival

Cited by 21 publications

References 52 publications

Racial differences in head and neck squamous cell carcinomas among non-Hispanic black and white males identified through the National Cancer Database (1998–2012)

Racial differences in head and neck squamous cell carcinomas among non-Hispanic black and white males identified through the National Cancer Database (1998–2012)

The Association of Age and Race and the Risk of Large Bowel Polyps

Distant Liver Metastases as a Major Factor Influencing Survival in Patients with Colorectal Cancer

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