Prognostic Factors in Patients with Locally Advanced Breast Cancer Treated by Neoadjuvant Chemotherapy

Jaegal, Min; Kang, Shin Jae; Ryu, Young Jae; Cho, Jin Seong; Park, Min Ho; Yoon, Jung Han

doi:10.14449/jbd.2019.7.1.23

Cited by 2 publications

(1 citation statement)

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“…Most articles reported results similar to ours. Jaegal et al [29] reported a higher pCR in patients with a high histologic grade. Wang et al [30] and Shien et al [7] reported significantly higher rates of pCR in patients with nuclear grade 3 compared to those in patients with nuclear grades 1 or 2.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of Tumor Elasticity and Clinicopathologic Factors Affecting Neoadjuvant Chemotherapy Response in Patients with Breast Cancer

et al. 2021

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This study aimed to determine the clinicopathologic factors, including tumor elasticity, affecting neoadjuvant chemotherapy response in breast cancer. Methods: Among 95 patients who received neoadjuvant chemotherapy for clinical stage IIa-IIIc primary breast cancer, 75 underwent strain elastography assessments. The patients were divided into soft and hard tumor groups based on the Tsukuba elasticity scoring system. Pathologic factors, including tumor cellularity and stromal characteristics, were evaluated using core needle biopsy specimens collected before neoadjuvant chemotherapy. Pathologic complete response (pCR) was defined as the absence of invasive carcinoma in the breast and axillary lymph nodes. Residual cancer burden (RCB) was also calculated in 79 cases. Results: Twenty-two patients achieved pCR (23.2%). The rates of estrogen receptor (ER) negativity (p= 0.04), progesterone receptor (PR) negativity (p= 0.03), and nuclear grade 3 (p= 0.03) were higher in patients with pCR than those in patients without pCR. The rates of PR negativity (p= 0.03), nuclear grade 3 (p= 0.01), and high tumor-infiltrating lymphocyte (TIL) levels (p= 0.04) were significantly higher in the favorable RCB group (RCB-0 and I) than those in the unfavorable RCB group (RCB-II and III). No significant difference in tumor elasticity was observed between the groups (p= 0.30). Hormone receptor (HR) negativity was an independent predictor of favorable RCB in the multivariate analysis (p= 0.04). Conclusion: Tumor elasticity was not associated with pCR or RCB. HR negativity was an independent predictor of favorable RCB.

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Section: Discussionmentioning

confidence: 95%

Evaluation of Tumor Elasticity and Clinicopathologic Factors Affecting Neoadjuvant Chemotherapy Response in Patients with Breast Cancer

et al. 2021

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Clinicopathological Features of Breast Cancer Patients according to Lymphatic Invasion

Jo¹,

Lee²,

Hong³

et al. 2020

J Breast Dis

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Breast cancer is the most common cancer in Korean women and the number of cases is increasing. We have found various histopathological differences in breast cancer and are using this knowledge for treatment. Various factors may help determine the progression of cancer in patients. The expression of lymphovascular invasion, a pathologic factor, denotes a poor prognosis. We analyzed the characteristics of patients showing lymphatic invasion. Methods: Data from 606 patients with breast cancer who underwent surgery between 2006 and 2016 were collected. We analyzed various pathologic factors in patients with or without lymphatic invasion expression. Results: Mean age was 52.0± 11.2 years (range 29-83 years) and mean follow-up duration was 57.3 months (range 3−125 months). Pathologically, breast cancer types were invasive ductal carcinoma (552, 91.2%), invasive lobular carcinoma (21, 3.4%), and other pathologies (33, 5.4%). Number of patients in stages I, II, III, and IV were 299 (49.3%), 223 (36.8%), 82 (13.7%), and 2 (0.02%), respectively. Immunohistochemistry revealed 396 (65.3%) estrogen receptor (ER)-positive cases, 287 (47.3%) progesterone receptor (PR)-positive cases, and 139 (22.9%) human epidermal growth factor receptor 2 (HER2)-positive cases. Seven patients had local recurrence and 41 patients had distant metastasis, which included 14 bone, 7 lung, 5 liver, and 15 multiple metastases. Seventeen patients showed lymphatic invasion, while 24 patients were without lymphatic invasion. Significant association was observed between T and N stages and lymphatic invasion (p< 0.001). No significant correlation was observed between lymphatic invasion and ER (p= 0.073), HER2 (p= 0.553). However, there was a significant correlation between lymphatic invasion and PR (p= 0.044). Overall survival and disease free survival rates were significantly worse in the presence of lymphatic invasion (p< 0.01, 0.011, respectively). Conclusion: Lymphatic invasion was associated with T and N stages, overall survival and disease free survival. More careful observation and treatment strategy is needed, especially in locally advanced breast cancer.

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Prognostic Factors in Patients with Locally Advanced Breast Cancer Treated by Neoadjuvant Chemotherapy

Cited by 2 publications

References 20 publications

Evaluation of Tumor Elasticity and Clinicopathologic Factors Affecting Neoadjuvant Chemotherapy Response in Patients with Breast Cancer

Evaluation of Tumor Elasticity and Clinicopathologic Factors Affecting Neoadjuvant Chemotherapy Response in Patients with Breast Cancer

Clinicopathological Features of Breast Cancer Patients according to Lymphatic Invasion

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