Prognostic Factors in Patients With Buccal Squamous Cell Carcinoma: 10-Year Experience

Jan, Jih-Chuan; Hsu, Wu‐Huei; Liu, Shih–An; Wong, Yong–Kie; Poon, Chiu-Kwan; Jiang, Rong–San; Jan, Jian‐Sheng; Chen, I.-Fan

doi:10.1016/j.joms.2010.05.017

Cited by 58 publications

(58 citation statements)

References 28 publications

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“…Unexpected close surgical margin after a radical surgery is frequently encountered in resected oral cancer patients [66-67]. In addition to surgeon effects, unexpected close surgical margins have been recognized partially as an aggressive cancer behavior [68-69].…”

Section: Discussionmentioning

confidence: 99%

DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study

et al. 2014

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Radioresistance is still an emerging problem for radiotherapy of oral cancer. Aberrant epigenetic alterations play an important role in cancer development, yet the role of such alterations in radioresistance of oral cancer is not fully explored. Using a methylation microarray, we identified promoter hypermethylation of FHIT (fragile histidine triad) in radioresistant OML1-R cells, established from hypo-fractionated irradiation of parental OML1 radiosensitive oral cancer cells. Further analysis confirmed that transcriptional repression of FHIT was due to promoter hypermethylation, H3K27me3 and overexpression of methyltransferase EZH2 in OML1-R cells. Epigenetic interventions or depletion of EZH2 restored FHIT expression. Ectopic expression of FHIT inhibited tumor growth in both in vitro and in vivo models, while also resensitizing radioresistant cancer cells to irradiation, by restoring Chk2 phosphorylation and G2/M arrest. Clinically, promoter hypermethylation of FHIT inversely correlated with its expression and independently predicted both locoregional control and overall survival in 40 match-paired oral cancer patient samples. Further in vivo therapeutic experiments confirmed that inhibition of DNA methylation significantly resensitized radioresistant oral cancer cell xenograft tumors. These results show that epigenetic silencing of FHIT contributes partially to radioresistance and predicts clinical outcomes in irradiated oral cancer. The radiosensitizing effect of epigenetic interventions warrants further clinical investigation.

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Section: Discussionmentioning

confidence: 99%

DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study

et al. 2014

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“…It should be emphasized that approximately two-thirds of cases are diagnosed at an advanced stage of disease (stage III-IV) and that tumor-node-metastasis (TNM) staging often does not explain the clinical behavior of the tumor (3)(4)(5)(6). For this reason, several studies have been performed on the biological patterns of the tumor, which are closely connected with its behavior (greater or lesser aggressiveness) and can predict the prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…For this reason, several studies have been performed on the biological patterns of the tumor, which are closely connected with its behavior (greater or lesser aggressiveness) and can predict the prognosis. Oncogenes expressed at varying percentages and associated modifications of chromosomal sites have been identified in oral tumors (4)(5)(6)(7)(8)(9)(10)(11)(12)(13). The p53 tumor suppressor gene (expressed in 4-50% of cases) is the most studied oncogene detected on chromosome 17, and it is clear that preliminary knowledge of the p53 status may be of great assistance in managing OSCC (14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

p53 as a prognostic marker associated with the risk of mortality for oral squamous cell carcinoma

et al. 2016

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Abstract. Oral squamous cell carcinoma (OSCC) is often associated with a poor prognosis. The purpose of the present study was to investigate survival and the risk of mortality in OSCC with regard to stage, tumor site and p53 expression. A retrospective study was performed on 150 non-consecutive cases of OSCC that were observed between January 1992 and January 2012, and were selected from a total of 580 patients according to the criteria of the homogeneity of histopathological grading (G2). The medical records were reviewed for 48 cases with disease at stage I [37 males, age 64.7±5.7 years (mean age±standard deviation); 11 females, age 70.0±3.37 years]; 27 cases with stage II (15 males, age 64.5±5.6 years; 12 females, age 69.2±3.9 years); 58 cases with stage IVa (42 males, age 66.9±5.3 years; 16 females, age 64.2±6.5 years); and 17 cases with stage IVb (16 males, age 65.7±5.4 years; 1 female, age 69 years). Monoclonal p53 antibody (clone DO-7) was used to perform the p53 immunohistochemical study. A significant association was found between the site of the tumor and p53 overexpression (P<0.0001). Stage I-II cases showed a higher cumulative probability of a 24-month survival time than stage IVa-IVb cases (P<0.0001). Cheek, floor and soft palate tumors showed a worse prognosis (P<0.0001) and tumors with p53 overexpression >50% showed a poor survival rate (P<0.0001) compared with tumors of the attached gingiva, tongue and retromolar trigone. The findings allowed the quantification of the risk mortality from OSSC with regard to stage, tumor site and the p53 expression pattern of the tumor.Data supported the absolute indications for wide surgical margins (radical surgery) in cases of T1-T2 N0 tumors of the tongue, floor, retromolar trigone and attached gingiva when p53 overexpression is >50% in association with a higher risk of mortality compared with when p53 overexpression is <50%.

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“…1,2 In a large 10-year multicohort study, Shaw et al 3 found that extracapsular spread (ECS) in patients with oral cavity squamous cell carcinoma (OCSCC) doubled the local recurrence rate, doubled the distant metastasis rate, and tripled the incidence of regional recurrence. However, recent literature has debated whether ECS affects disease-specific survival in patients with p16-positive or p16-negative oropharyngeal squamous cell carcinoma (OPSCC).…”

mentioning

confidence: 99%

Accuracy of Preoperative Imaging in Detecting Nodal Extracapsular Spread in Oral Cavity Squamous Cell Carcinoma

Aiken¹,

Poliashenko

Beitler³

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The increasing impact of diagnosing extracapsular spread by using imaging, especially in patients with oropharyngeal squamous cell carcinoma, highlights the need to rigorously evaluate the diagnostic accuracy of imaging. Previous analysis suggested 62.5%-80.9% sensitivity and 60%-72.7% specificity. Our goals were to evaluate the accuracy of imaging in diagnosing extracapsular spread in a cohort of patients with oral cavity squamous cell carcinoma (pathologic confirmation of extracapsular spread routinely available), as a proxy for oropharyngeal squamous cell carcinoma, and to independently assess the reliability of imaging features (radiographic lymph node necrosis, irregular borders/stranding, gross invasion, and/or node size) in predicting pathologically proven extracapsular spread.

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Prognostic Factors in Patients With Buccal Squamous Cell Carcinoma: 10-Year Experience

Cited by 58 publications

References 28 publications

DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study

DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study

p53 as a prognostic marker associated with the risk of mortality for oral squamous cell carcinoma

Accuracy of Preoperative Imaging in Detecting Nodal Extracapsular Spread in Oral Cavity Squamous Cell Carcinoma

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